Cancer Stem Cell News Volume 11.40 | Nov 2 2022

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    2022-11-02 | CSCN 11.40


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.40 – 2 November, 2022
    TOP STORY

    Olaparib Efficacy in Patients With Metastatic Castration-Resistant Prostate Cancer and BRCA1, BRCA2 or ATM Alterations Identified by Testing Circulating Tumor DNA

    The authors presented exploratory analyses on the use of ctDNA testing as an additional method to identify castration-resistant prostate cancer patients with homologous recombination repair gene alterations who may be eligible for olaparib treatment.
    [Clinical Cancer Research]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    ATF3 Reprograms the Bone Marrow Niche in Response to Early Breast Cancer Transformation

    Using a spontaneous model of mammary carcinoma, investigators identified bone marrow (BM) mesenchymal stem cells as the first sensors of distal cancer cells and key mediators of BM reprogramming.
    [Cancer Research]

    AbstractFull Article

    Meis1 Supports Leukemogenesis through Stimulation of Ribosomal Biogenesis and Myc

    While HoxA9 alone immortalizes cells, cooperation with Meis1 is necessary to induce a full leukemic phenotype. Here, the authors applied degron techniques to elucidate the leukemogenic contribution of Meis1.
    [Haematologica]

    Abstract

    LINC00589-Dominated ceRNA Networks Regulate Multiple Chemoresistance and Cancer Stem Cell-Like Properties in HER2+ Breast Cancer

    Researchers identified the long noncoding RNA, LINC00589 as a key regulatory node for concurrent intervention of multiple chemoresistance and cancer stem cell-like properties in breast cancer cells in vitro and in vivo.
    [npj Breast Cancer]

    Full Article

    Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription

    Scientists demonstrated that Sohlh2 was related to the inhibition of LncRNA-H19/miR-141/β-catenin signaling and led to the consequent suppression of colon cancer stem cell (CSC) stemness and the promotion of colon CSC differentiation in vitro and in vivo.
    [Molecular Cancer Research]

    Abstract

    DOT1L Regulates Ovarian Cancer Stem Cells by Activating β-Catenin Signaling

    ShRNA-mediated H3K79 methyltransferase disruptor of telomeric silencing-1-like (DOT1L) knockdown decreased the aldehyde dehydrogenase + cell population, impaired the tumor initiation capacity of ovarian CSCs, and blocked the expression of stemness-associated genes.
    [Molecular Cancer Research]

    Full Article

    Extracellular Vesicles microRNA-592 of Melanoma Stem Cells Promotes Metastasis through Activation of MAPK/ERK Signaling Pathway by Targeting PTPN7 in Non-stemness Melanoma Cells

    Scientists demonstrated that the extracellular vesicles-mediated crosstalk between melanoma stem cells and melanoma parental cells was a novel mechanism for melanoma metastasis.
    [Cell Death Discovery]

    Full Article

    Cancer-Associated Fibroblasts Promote the Stemness and Progression of Renal Cell Carcinoma via Exosomal miR-181d-5p

    Mechanistically, exosomal miR-181d-5p transferred from cancer associated fibroblasts to recal cell carcinoma cells directly suppressed the expression of ring finger protein 43, and activated the Wnt/β-catenin signaling pathway, thus promoting cancer stemness and tumor progression.
    [Cell Death Discovery]

    Full Article

    Crosstalk Between HSF1 and STAT3 Mediated by IL-8 Autocrine Signaling Maintains the Cancer Stem Cell Phenotype in Liver Cancer

    Researchers established two liver cancer stem cells (LCSC) lines, HepG2-R and HuH-7-R. Constitutive activation of HSF1 was observed in these LCSCs.
    [Journal of Gastroenterology and Hepatology]

    Full Article
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    REVIEWS

    Cancer Stem Cells in Immunoregulation and Bypassing Anti-checkpoint Therapy

    The authors discuss about connections between CSCs with the immune ecosystem of tumors and the impact of such interactions on cancer responses to immune checkpoint inhibitor therapy.
    [Biomedicine & Pharmacotherapy]

    Full Article

    Role of Vitamin D in Targeting Cancer and Cancer Stem Cell Populations and Its Therapeutic Implications

    Scientists investigated the therapeutic impact of vitamin D and its molecular processes to target cancer and cancer stem cells.
    [Medical Oncology]

    Full ArticleGraphical Abstract
    FEATURED EVENT

    AACR Special Conference: Cancer Metastasis

    November 14 – 17, 2022
    Portland, Oregon, United States

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Cancer Regulators

    University of Texas Health Science Center at Houston – Houston, Texas, United States

    Medical Science Liaison – Breast Cancer

    AstraZeneca – Mississauga, Ontario, Canada

    Postdoctoral Associate – Therapy-Resistance of Human Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Senior Bioinformaticians – Skin Cancer Research

    Wellcome Genome Campus – Saffron Walden, England, United Kingdom

    Research Associate – Cell Signaling Research

    University of Nottingham – Nottingham, England, United Kingdom

    > See All Jobs

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