 | | Vol. 11.40 – 2 November, 2022 |
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| The authors presented exploratory analyses on the use of ctDNA testing as an additional method to identify castration-resistant prostate cancer patients with homologous recombination repair gene alterations who may be eligible for olaparib treatment.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a spontaneous model of mammary carcinoma, investigators identified bone marrow (BM) mesenchymal stem cells as the first sensors of distal cancer cells and key mediators of BM reprogramming.
[Cancer Research] |
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| While HoxA9 alone immortalizes cells, cooperation with Meis1 is necessary to induce a full leukemic phenotype. Here, the authors applied degron techniques to elucidate the leukemogenic contribution of Meis1.
[Haematologica] |
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| Researchers identified the long noncoding RNA, LINC00589 as a key regulatory node for concurrent intervention of multiple chemoresistance and cancer stem cell-like properties in breast cancer cells in vitro and in vivo.
[npj Breast Cancer] |
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| Scientists demonstrated that Sohlh2 was related to the inhibition of LncRNA-H19/miR-141/β-catenin signaling and led to the consequent suppression of colon cancer stem cell (CSC) stemness and the promotion of colon CSC differentiation in vitro and in vivo.
[Molecular Cancer Research] |
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| ShRNA-mediated H3K79 methyltransferase disruptor of telomeric silencing-1-like (DOT1L) knockdown decreased the aldehyde dehydrogenase + cell population, impaired the tumor initiation capacity of ovarian CSCs, and blocked the expression of stemness-associated genes.
[Molecular Cancer Research] |
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| Scientists demonstrated that the extracellular vesicles-mediated crosstalk between melanoma stem cells and melanoma parental cells was a novel mechanism for melanoma metastasis.
[Cell Death Discovery] |
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| Mechanistically, exosomal miR-181d-5p transferred from cancer associated fibroblasts to recal cell carcinoma cells directly suppressed the expression of ring finger protein 43, and activated the Wnt/β-catenin signaling pathway, thus promoting cancer stemness and tumor progression.
[Cell Death Discovery] |
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| Researchers established two liver cancer stem cells (LCSC) lines, HepG2-R and HuH-7-R. Constitutive activation of HSF1 was observed in these LCSCs.
[Journal of Gastroenterology and Hepatology] |
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| The authors discuss about connections between CSCs with the immune ecosystem of tumors and the impact of such interactions on cancer responses to immune checkpoint inhibitor therapy.
[Biomedicine & Pharmacotherapy] |
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| Scientists investigated the therapeutic impact of vitamin D and its molecular processes to target cancer and cancer stem cells.
[Medical Oncology] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | AstraZeneca – Mississauga, Ontario, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Wellcome Genome Campus – Saffron Walden, England, United Kingdom |
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| | University of Nottingham – Nottingham, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
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Mammary Cell News
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