 | | Vol. 12.16 – 26 April, 2023 |
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| Researchers reported a mechanism of WNT pathway activation through the Semaphorin 3 C (Sema3C) neurodevelopmental program in glioma stem-like cells.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that a cellular subpopulation with partial epithelial-mesenchymal transition-like signature marked by high expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) was the origin of heterogeneous tumor cells in pancreatic ductal adenocarcinoma.
[Embo Journal] |
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| Meningioma stem cells were isolated from patient-derived primary cultures in stem cell-permissive conditions, and characterized for phenotype, self-renewal, proliferation and migration rates, vasculogenic mimicry, and in vivo tumorigenesis.
[Neuro-Oncology] |
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| Scientists comprehensively evaluated the significance of a novel invasion-related protein, Family with Sequence Similarity 129 Member A (FAM129A), in infiltrative glioma stem cells.
[Neuro-Oncology] |
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| Researchers reported ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of ovarian cancer (OC) regulating cancer stemness, identifying ISYNA1 as a differentially expressed gene in normal ovary and ovarian cancer tissues, as well as OC cells and ovarian cancer stem cells.
[Cellular Signalling] |
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| Flow cytometry and immunohistochemical analysis were checked for immune infiltration on MC38 mice model. Human colorectal cancer tissues were tested with RT-qPCR.
[Cancer Medicine] |
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| The authors developed a novel melanoma stem cells vaccine that induced CD8+T cells to target melanoma stem cells specifically.
[Human Vaccines & Immunotherapeutics] |
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| The amino acid profile change during the enrichment of breast cancer stem cells in spheroids was investigated by high-performance liquid chromatography.
[Cancer Reports] |
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| LXR inhibitor SR9243-loaded immunoliposomes improved the reduction of clonogenicity, stemness, and lipogenesis in CD133 + cancer stem cells in vitro, boosted reactive oxygen species generation, and induced apoptosis.
[Medical Oncology] |
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| To better understand circulating tumor cells (CTC) journey in the microcirculation as part of the metastatic cascade, scientists review how CTC mechanobiology and interaction with other cell types in the bloodstream help them to survive the harsh conditions in the circulatory system and to metastasize in distant organs.
[Frontiers In Cell And Developmental Biology] |
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| The authors focus on the plant-derived compounds that aid in cancer therapy by inhibiting cancer stem cells, metastasis, creating immunogenic responses, along with summarizing on miRNAs involved in cancer and regulating the plant-based drugs and vice-versa.
[Frontiers In Pharmacology] |
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| IN8bio, Inc. announced FDA orphan drug designation for INB-400 and INB-410, covering a broad range of malignant glioma treatments, including newly diagnosed glioblastoma multiforme, marking the first-ever orphan drug designation for genetically modified gamma-delta T cell therapies.
[IN8bio, Inc.] |
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| | UNMC Pancreatic Cancer Center of Excellence – Omaha, Nebraska, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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