Cancer Stem Cell News Volume 12.16 | Apr 26 2023

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    2023-04-26 | CSCN 12.16


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.16 – 26 April, 2023
    TOP STORY

    Sema3C Signaling Is an Alternative Activator of the Canonical WNT Pathway in Glioblastoma

    Researchers reported a mechanism of WNT pathway activation through the Semaphorin 3 C (Sema3C) neurodevelopmental program in glioma stem-like cells.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    YAP/BRD4-Controlled ROR1 Promotes Tumor-Initiating Cells and Hyperproliferation in Pancreatic Cancer

    Scientists showed that a cellular subpopulation with partial epithelial-mesenchymal transition-like signature marked by high expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) was the origin of heterogeneous tumor cells in pancreatic ductal adenocarcinoma.
    [Embo Journal]

    Full ArticleGraphical Abstract

    Stem-Like Signatures in Human Meningioma Cells Are under the Control of CXCL11/CXCL12 Chemokine Activity

    Meningioma stem cells were isolated from patient-derived primary cultures in stem cell-permissive conditions, and characterized for phenotype, self-renewal, proliferation and migration rates, vasculogenic mimicry, and in vivo tumorigenesis.
    [Neuro-Oncology]

    Abstract

    FAM129A Promotes Self-Renewal and Maintains Invasive Status via Stabilizing the Notch Intracellular Domain in Glioma Stem Cells

    Scientists comprehensively evaluated the significance of a novel invasion-related protein, Family with Sequence Similarity 129 Member A (FAM129A), in infiltrative glioma stem cells.
    [Neuro-Oncology]

    Abstract
    Graphical Abstract

    The Myo-Inositol Biosynthesis Rate-Limiting Enzyme ISYNA1 Suppresses the Stemness of Ovarian Cancer via Notch1 Pathway

    Researchers reported ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of ovarian cancer (OC) regulating cancer stemness, identifying ISYNA1 as a differentially expressed gene in normal ovary and ovarian cancer tissues, as well as OC cells and ovarian cancer stem cells.
    [Cellular Signalling]

    Full ArticleGraphical Abstract

    Effects of SMC1A on Immune Microenvironment and Cancer Stem Cells in Colon Adenocarcinoma

    Flow cytometry and immunohistochemical analysis were checked for immune infiltration on MC38 mice model. Human colorectal cancer tissues were tested with RT-qPCR.
    [Cancer Medicine]

    Full Article

    Melanoma Stem Cell Vaccine Induces Effective Tumor Immunity against Melanoma

    The authors developed a novel melanoma stem cells vaccine that induced CD8+T cells to target melanoma stem cells specifically.
    [Human Vaccines & Immunotherapeutics]

    Full Article

    Amino Acid Profile Changes During Enrichment of Spheroid Cells with Cancer Stem Cell Properties in MCF-7 and MDA-MB-231 Cell Lines

    The amino acid profile change during the enrichment of breast cancer stem cells in spheroids was investigated by high-performance liquid chromatography.
    [Cancer Reports]

    Full Article

    LXR Inhibitor SR9243-Loaded Immunoliposomes Modulate Lipid Metabolism and Stemness in Colorectal Cancer Cells

    LXR inhibitor SR9243-loaded immunoliposomes improved the reduction of clonogenicity, stemness, and lipogenesis in CD133 + cancer stem cells in vitro, boosted reactive oxygen species generation, and induced apoptosis.
    [Medical Oncology]

    AbstractGraphical Abstract
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    REVIEWS

    Mechanobiology and Survival Strategies of Circulating Tumor Cells: A Process Towards the Invasive and Metastatic Phenotype

    To better understand circulating tumor cells (CTC) journey in the microcirculation as part of the metastatic cascade, scientists review how CTC mechanobiology and interaction with other cell types in the bloodstream help them to survive the harsh conditions in the circulatory system and to metastasize in distant organs.
    [Frontiers In Cell And Developmental Biology]

    Abstract

    A Comprehensive Review on Phytomedicines and Their Effect on Cancer Stem Cells and Metastasis

    The authors focus on the plant-derived compounds that aid in cancer therapy by inhibiting cancer stem cells, metastasis, creating immunogenic responses, along with summarizing on miRNAs involved in cancer and regulating the plant-based drugs and vice-versa.
    [Frontiers In Pharmacology]

    Abstract
    INDUSTRY AND POLICY NEWS

    IN8bio Receives FDA Orphan Drug Designation for INB-400/410 for the Treatment of Newly Diagnosed Glioblastoma

    IN8bio, Inc. announced FDA orphan drug designation for INB-400 and INB-410, covering a broad range of malignant glioma treatments, including newly diagnosed glioblastoma multiforme, marking the first-ever orphan drug designation for genetically modified gamma-delta T cell therapies.
    [IN8bio, Inc.]

    Press Release
    FEATURED EVENT

    Advances in Cancer Immunotherapy™: A Focus on Pediatric Cancers

    May 3, 2023
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Pancreatic Cancer

    UNMC Pancreatic Cancer Center of Excellence – Omaha, Nebraska, United States

    Postdoctoral Position – Cancer Metabolism, Epigenetics, and Hematopoiesis Research

    University of Texas Health Science Center – San Antonio, Texas, United States

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Glioblastoma

    University of Oklahoma – Oklahoma City, Oklahoma, United States

    Postdoctoral Fellow – Tumor Suppressor p53

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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