Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-Like Properties NF-κBs function in tumor-initiating cells has not been examined yet. Using a genetic model of intestinal epithelial cell (IEC)-restricted constitutive Wnt-activation, which comprises the most common event in the initiation of colon cancer, scientists demonstrated that NF-κB modulates Wnt signaling and showed that IEC-specific ablation of RelA/p65 retards crypt stem cell expansion. [Cell] Abstract | Graphical Abstract Metformin Inhibits the Inflammatory Response Associated with Cellular Transformation and Cancer Stem Cell Growth Researchers’ observations suggest that metformin inhibits a signal transduction pathway that results in an inflammatory response. As metformin alters energy metabolism in diabetics, they speculated that metformin may block a metabolic stress response that stimulates the inflammatory pathway associated with a wide variety of cancers. [Proc Natl Acad Sci USA] Abstract MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-Like Population of Nasopharyngeal Carcinoma Cells A stem cell-like subpopulation (PKH26+) was identified in nasopharyngeal carcinoma cell lines using a label retention technique. This study elucidates the role of the c-Myc (MYC)-Chk1/Chk2 axis in regulating DNA damage checkpoint responses and stem cell characteristics in the PKH26+ subpopulation. [Cancer Res] Abstract Wnt/β-Catenin Signaling Is a Key Downstream Mediator of MET Signaling in Glioblastoma Stem Cells Data suggest that Wnt/β-catenin signaling is a key downstream effector of MET signaling and contributes to the maintenance of glioblastoma stem cell and glioblastoma malignancy. [Neuro Oncol] Abstract Metformin Selectively Affects Human Glioblastoma Tumor-Initiating Cell Viability: A Role for Metformin-Induced Inhibition of Akt Investigators report that metformin treatment reduced the proliferation rate of tumor-initiating cell-enriched cultures isolated from four human glioblastomas. [Cell Cycle] Abstract p53 Restoration Kills Primitive Leukemia Cells In Vivo and Increases Survival of Leukemic Mice Results suggest that reestablishing p53 function may be a therapeutic strategy for the eradication of leukemic stem cells and to prevent disease progression. [Cell Cycle] Abstract Focal Adhesion Kinase Scaffolding Function to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activities In Vivo Scientists report that disruption of focal adhesion kinase (FAK) scaffolding function through its P878/881 motif suppressed mammary tumor growth and metastasis in a well characterized murine model of human breast cancer. P878/881A mutation in the endogenous FAK gene decreased the expression of markers for epithelial-mesenchymal transition and mammary cancer stem cell activities in tumors derived from the mutant mice. [J Biol Chem] Abstract | Full Article MiR-125b Functions as a Key Mediator for Snail-Induced Stem Cell Propagation and Chemoresistance The authors report a novel mechanism that upregulation of miR-125b through Wnt signaling by Snail enriches cancer stem cells. [J Biol Chem] Abstract | Full Article Regulation of Expression of ABCB1 and LRP Genes by Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway and its Role in Generation of Side Population Cells in Canine Lymphoma Cell Lines The concept of the cancer stem cell (CSC) has been recognized as key for elucidation of the mechanisms that confer the multidrug resistance phenotype to tumor cells, and the side population (SP) fraction has been shown to be enriched by cells with the CSC phenotype. Researchers aimed to identify the mechanism that induces a difference of phenotype between the SP and the remaining major population using two canine lymphoma cell lines. [Leuk Lymphoma] Abstract A Possible Usage of a CDK4 Inhibitor for Breast Cancer Stem Cell-Targeted Therapy Researchers found that a CDK4 inhibitor sensitized MDA-MB-231 cells but not MCF7 cells to irradiation. This difference appeared to be associated with the relative percentage of cancer stem cell-population between the two breast cancer cells. [Biochem Biophys Res Commun] Abstract |