Microenvironmental Protection of CML Stem and Progenitor Cells from Tyrosine Kinase Inhibitors through N-Cadherin and Wnt-β-Catenin Signaling Scientists investigated whether signals from the bone marrow microenvironment protect chronic myeloid leukemia (CML) stem cells from tyrosine kinase inhibitor treatment. [Blood] Abstract Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics Scientists proposed a cellular Potts model that simulates the kinetics of glioma stem cells and cancer cells in glioblastoma growth and radiation response. They parameterized and validated this model with experimental data of the U87-MG human glioblastoma cell line. [Cancer Res] Abstract Lin28 Regulates BMP4 and Functions with Oct4 to Affect Ovarian Tumor Microenvironment Elevated production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has been shown to increase cancer stem cell (CSC) proliferation and tumor growth. Here, investigators report that Lin28, a stem cell factor, binds to BMP4 mRNA in epithelial ovarian carcinoma cells, thereby promoting BMP4 expression at the post-transcriptional level. As co-expression of Lin28 and Oct4 has been implicated in ovarian cancer CSCs, they also determined that high levels of Lin28 are associated with an unfavorable prognosis when co-expressed with high levels of Oct4. [Cell Cycle] Abstract | Press Release MLL-Rearranged Acute Lymphoblastic Leukemia Stem Cell Interactions with Bone Marrow Stroma Promote Survival and Therapeutic Resistance that Can Be Overcome with CXCR4 Antagonism Researchers hypothesized that interactions between leukemia stem cells and the bone marrow microenvironment mediate survival and chemotherapy resistance in MLL-rearranged acute lymphoblastic leukemia. [Br J Haematol] Abstract 2-Hydroxycinnamaldehyde Inhibits the Epithelial-Mesenchymal Transition in Breast Cancer Cells Since epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and in maintaining cancer stem cell properties, EMT is emerging as a therapeutic target for inhibiting the metastatic progression of cancer cells. Researchers investigated the anti-metastatic effect of 2′-Hydroxycinnamaldehyde (HCA) on breast cancer and the molecular mechanisms by which HCA regulates the transcriptional program during EMT. [Breast Cancer Res Treat] Abstract Multipotent Cancer Stem Cells Derived from Human Malignant Peritoneal Mesothelioma Promote Tumorigenesis Investigators developed and characterized a cancer stem cell (CSC) model for malignant peritoneal mesothelioma (MPeM) using stably expandable tumorigenic stem cells derived from patient tumors. They found morphologically distinct populations of CSCs that divide asymmetrically or symmetrically in MPeM in vitro cell culture. [PLoS One] Full Article Determining Duration of HER2-Targeted Therapy Using Stem Cell Extinction Models In order to guide clinical trials examining HER2-targeted therapy in the adjuvant setting, researchers proposed a mathematical model to examine breast cancer stem-like cell population dynamics and predict optimal duration of therapy. [PLoS One] Full Article EZH2 Is Required for Breast and Pancreatic Cancer Stem Cell Maintenance and Can Be Used as a Functional Cancer Stem Cell Reporter Cancer stem cells (CSCs) isolated from pancreatic and breast cancer lines had elevated EZH2 levels over non-CSCs. EZH2 knockdown by RNA interference significantly reduced the frequency of CSCs in all models tested, confirming the role of EZH2 in maintenance of the CSC population. [Stem Cells Transl Med] Abstract |