Cancer Stem Cell News Volume 2.15 | Apr 17 2013


    Cancer Stem Cell News 2.15 April 17, 2013
         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    1B50-1, a mAb Raised against Recurrent Tumor Cells, Targets Liver Tumor-Initiating Cells by Binding to the Calcium Channel α2δ1 Subunit
    The authors generated a monoclonal antibody against recurrent hepatocellular carcinoma, 1B50-1, that bound the isoform 5 of the α2δ1 subunit of voltage-gated calcium channels and identified a subset of tumor-initiating cells with stem cell-like properties. [Cancer Cell] Abstract

    Culture Human Glioma-Derived Tumorspheres with NeuroCult™ - View Publications

    PUBLICATIONS (Ranked by impact factor of the journal)

    A Novel Model for Evaluating Therapies Targeting Human Tumor Vasculature and Human Cancer Stem-Like Cells
    Preclinical in vivo studies testing anti-human tumor vascular marker (TVM) therapies have been difficult to perform due to a lack of in vivo models with confirmed expression of human TVMs. Investigators therefore evaluated TVM expression in a human embryonic stem cell derived teratoma tumor model previously shown to have human vessels. This model represents a useful tool to test anti-human TVM therapy and evaluate in vivo human cancer stem-like cell tumor biology. [Cancer Res] Abstract

    Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells
    To investigate epigenetic regulation of genes in the tumor-initiating population of pancreatic cancer cells, which are also termed cancer stem cells (CSCs), researchers conducted epigenetic arrays in PANC1 and HPAC pancreatic cancer cell lines and compared the global DNA methylation status of CpG promoters in invasive cells, demonstrated to be CSCs, to their non-invasive counterparts, or non-CSCs. [Stem Cells] Abstract | Full Article

    FoxG1 Interacts with Bmi1 to Regulate Self-Renewal and Tumorigenicity of Medulloblastoma Stem Cells
    Since increasing brain tumor-initiating cell frequency has been associated with increasing tumor aggressiveness and poor patient outcome, scientists investigated the subgroup-specific gene expression profile of candidate stem cell genes within 251 primary human medulloblastomas (MBs) from four non-overlapping MB transcriptional databases and 74 NanoString-subgrouped MBs. [Stem Cells] Abstract

    Oncostatin-M Promotes Phenotypic Changes Associated with Mesenchymal and Stem Cell-Like Differentiation in Breast Cancer
    Stimuli that induce epithelial-to-mesenchymal transition (EMT) and cancer stem cell-like features (‘stemness’) are poorly defined. Researchers aimed to determine whether oncostatin-M is a cell-extrinsic driver of EMT and/or stemness. [Oncogene] Abstract

    p38MAPK Inhibition: A New Combined Approach to Reduce Neuroblastoma Resistance Under Etoposide Treatment
    This study was carried out on three stage-IV neuroblastoma cell lines with different status of MYCN amplification. Cells were exposed to a standard chemotherapy agent, namely etoposide, either alone or in combination with particular drugs, which target intracellular signaling pathways. Etoposide alone induced a concentration-dependent reduction of cell viability and, at very high doses, totally counteracted cell tumorigenicity and neurosphere formation. [Cell Death Dis] Full Article

    Tumor-Associated CD66b+ Neutrophil Count Is an Independent Prognostic Factor for Recurrence in Localized Cervical Cancer
    The prognostic impact of tumor-promoting immune cells in cervical cancer is unclear. Federation of Gynaecology and Obstetrics stage IB and IIA cervical cancer patients were assessed for tumor-associated CD66b+ neutrophils and CD163+ macrophages by immunohistochemistry in whole tissue sections using stereology. Results were correlated with previous results on tumor-infiltrating CD3+, CD4+, and CD8+ lymphocytes in the same cohort with recurrence-free survival as end point. [Br J Cancer] Abstract

    Paclitaxel-Fe3O4 Nanoparticles Inhibit Growth of CD138 CD34 Tumor Stem-Like Cells in Multiple Myeloma-Bearing Mice
    Researchers investigated the inhibitory effect of paclitaxel-loaded Fe3O4 nanoparticles on CD138 CD34 tumor stem cells in multiple myeloma-bearing mice. [Int J Nanomed] Abstract

    Retinoic Acid Represses Invasion and Stem Cell Phenotype by Induction of the Metastasis Suppressors RARRES1 and LXN
    Investigators identified the retinoic acid receptor responder 1 (RARRES1) gene and LXN as highly significantly downregulated genes in human prostate stem cells, whose expression was induced by the pro-differentiation agent all-trans retinoic acid. [Oncogenesis] Full Article

    NeuroCult™ for Brain Tumor Research - View Publications

    Cancer Stem Cells in Lung Cancer: Evidence and Controversies
    The authors review the evidence regarding the existence and function of lung cancer stem cells in the context of the experimental and clinical evidence and discuss some ongoing controversies regarding this model. [Respirology] Abstract

    Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.


    Stem Cell Therapeutics Licenses Exclusive Rights to Clinical Cancer Stem Cell Program
    Stem Cell Therapeutics Corp. announced the execution of a definitive license agreement with University Health Network, Toronto, Canada. The agreement, developed in collaboration with MaRS Innovation, provides Stem Cell Therapeutics with exclusive worldwide rights to an innovative clinical cancer stem cell program. [Marketwire] Press Release

    Immunotherapies against Cancer: German Cancer Research Center to Broaden Strategic Alliance with Bayer HealthCare
    The German Cancer Research Center and Bayer HealthCare will extend their successful strategic research alliance in search of novel cancer therapeutics by focusing their activities also on the field of immunotherapy. [German Cancer Research Center] Press Release

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    NEW Cold Spring Harbor Laboratory: Mouse Development, Stem Cells & Cancer
    June 5-25, 2013
    Cold Spring Harbor, United States

    Visit our
    events page to see a complete list of events in the cancer stem cell community.


    PhD Studentship Opportunity (University of East Anglia)

    Postdoctoral Fellow – Epigenetics (Structural Genomics Consortium at University of Toronto)

    PhD Student (Universitätsklinikum Carl Gustav Carus)

    Faculties in Cancer Biology & Immunotherapy (Huzhou University School of Medicine)

    Postdoctoral Researcher – Pancreatic Cancer (University of Notre Dame, Department of Biological Sciences)

    Postdoctoral Associate (University of California, Berkeley)

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