Triple Negative Breast Cancer Initiating Cell Subsets Differ in Functional and Molecular Characteristics and in γ-Secretase Inhibitor Drug Responses Breast tumor-initiating stem cells (T-ISCs) are known to be enriched in CD44+CD24neg/low cells. Investigators identified two T-ISC subsets within this population in triple negative breast cancer lines and dissociated primary breast cancer cultures: CD44+CD24low+ subpopulation generates CD44+CD24neg progeny with reduced sphere formation and tumorigenicity. [EMBO Mol Med] Full Article p27kip1 Maintains a Subset of Leukemia Stem Cells in the Quiescent State in Murine MLL-Leukemia p27 deletion significantly compromises the leukemogenic capacity of CD117+CD11blo MLL-AF9-leukemic cells (LCs) by reducing the frequency of leukemic stem cells but does not do so in HOXA9/MEIS1-LCs [Mol Oncol] [Mol Oncol] Abstract Radiation-Induced Notch Signaling in Breast Cancer Stem Cells Scientists showed that Notch receptor and ligand expression during the first 48 hours after irradiation followed a complex radiation dose-dependent pattern and was most pronounced in mammospheres, enriched for breast cancer stem cells. [Int J Radiat Oncol Biol Phys] Abstract Alteration of Cancer Stem Cell-Like Phenotype by Histone Deacetylase Inhibitors in Squamous Cell Carcinoma of the Head and Neck The authors investigated the effects of two histone deacetylase inhibitors, suberoylanilide hydroxamic acid and trichostatin A, on two CD44+ cancer stem-like cell lines from SCCHN cultured in serum-free medium containing epidermal growth factor and basic fibroblast growth factor. [Cancer Sci] Abstract Expansion of CD133-Positive Glioma Cells in Recurrent De Novo Glioblastomas after Radiotherapy and Chemotherapy Laboratory Investigation Recent evidence suggests that a glioma stem cell subpopulation may determine the biological behavior of tumors, including resistance to therapy. To investigate this hypothesis, the authors examined varying grades of gliomas for stem cell marker expressions and histopathological changes between primary and recurrent tumors. [J Neurosurg] Abstract Clinical Significances and Prognostic Value of Cancer Stem-Like Cells Markers and Vasculogenic Mimicry in Renal Cell Carcinoma Scientists investigated the clinical significances and prognostic value of CD133 and CD44 (markers of cancer stem-like cells), and vasculogenic mimicry in renal cell carcinoma. [J Surg Oncol] Abstract Effects of Ellipticine on ALDH1A1-Expressing Breast Cancer Stem Cells-An In Vitro and In Silico Study Investigators examined the plant alkaloid ellipticine for its efficacy to inhibit the expression of aldehyde dehydrogenase 1 class A1 (ALDH1A1)-positive breast cancer stem cells by in vitro and in silico methods. [Tumor Biol] Abstract Expression of Cancer Stem Cell Markers Is More Frequent in Anaplastic Thyroid Carcinoma Compared to Papillary Thyroid Carcinoma and Is Related to Adverse Clinical Outcome Researchers explored the expression of various cancer stem cell markers in thyroid carcinoma tissues and analyzed their clinical significance. [J Clin Pathol] Abstract Implication of Tumor Stem-Like Cells in the Tumorigenesis of Sporadic Paraganglioma Researchers found a subgroup of human paraganglioma from ten clinical samples displayed definitive markers of CD133 and/or nestin, the fundamental features of neural stem cells capable of self-renewal and differentiation. [Med Oncol] Abstract Identification of FDA-Approved Drugs Targeting Breast Cancer Stem Cells along with Biomarkers of Sensitivity Gene expression datasets of cancer stem cells (CSCs) from six studies were subjected to connectivity map to identify drugs that may ameliorate gene expression patterns unique to CSCs. All-trans retinoic acid was negatively connected with gene expression in CSCs. [Sci Rep] Full Article |