The Stem Cell Factor SOX2 Regulates the Tumorigenic Potential in Human Gastric Cancer Cells To elucidate the role of Sox2 in gastric tumorigenesis, Sox2 transcriptional activity was blocked in AZ-521 cells. Inhibition of Sox2 reduced cell proliferation and migration, increased apoptosis and induced changes in cell cycle. [Carcinogenesis] Abstract Sorcin Silencing Inhibits Epithelial-to-Mesenchymal Transition and Suppresses Breast Cancer Metastasis In Vivo Researchers demonstrated that sorcin depletion in MDA-MB-231 breast cancer cells reduces the pool of CD44+/CD24– and ALDH1high cancer stem cells as well as mammosphere-forming capacity. [Breast Cancer Res Treat] Abstract Distribution of LGR5+ Cells and Associated Implications during the Early Stage of Gastric Tumorigenesis Lineage tracing indicates that Lgr5+ cells may not only be the cells responsible for the origin of tumors; they may also be the so-called cancer stem cells. Scientists investigated the presence of Lgr5+ cells and their biological significance in normal human gastric mucosa and gastric tumors. [PLoS One] Full Article Isolation of Cancer Stem Like Cells from Human Adenosquamous Carcinoma of the Lung Supports a Monoclonal Origin from a Multipotential Tissue Stem Cell Investigators isolated and characterized cancer stem-like populations from adenosquamous carcinoma through application of selective defined culture medium initially used to grow human lung stem cells. [PLoS One] Full Article | Press Release Genistein Decreases the Breast Cancer Stem-Like Cell Population through Hedgehog Pathway Researchers aimed to evaluate genistein inhibition of breast cancer stem-like cells and its potential mechanism by culturing MCF-7 breast cancer cells and implanting these cells into nude mice. [Stem Cell Res Ther] Abstract | Full Article SP Cell Fractions from HCC Cell Lines Increased with Tumor Dedifferentiation, but Lack Characteristic Features of CSCs Putative cancer stem cell (CSC) markers, such as CD13, CD90, CD133, and EpCAM, and side population (SP) technique are generally used in an attempt to isolate CSCs. Investigators aimed to clarify the relationship between CSCs and clonal dedifferentiation in hepatocellular carcinoma (HCC). [J Gastroenterol Hepatol] Abstract A 3D Multiscale Model of Cancer Stem Cell in Tumor Development A novel 3D multi-scale mathematical modeling was proposed to investigate the behaviors of cancer stem cells (CSCs) in tumor progressions. The model integrates CSCs, progenitor tumor cells, and differentiated tumor cells together with a few essential microenvironment factors. [BMC Systems Biol] Full Article Knockdown of Bmi1 Inhibits the Stemness Properties and Tumorigenicity of Human Bladder Cancer Stem Cell-Like Side Population Cells Investigators aimed to assess the role of B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) in the maintenance of stemness properties and tumorigenicity of human bladder cancer stem cell-like side population cells. [Oncol Rep] Abstract |