Cancer Stem Cell News Volume 3.10 | Mar 19 2014


    Cancer Stem Cell News 3.10 March 19, 2014

    Cancer Stem Cell News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    Cancer Stem-Like Cells Derived from Chemoresistant Tumors Have a Unique Capacity to Prime Tumorigenic Myeloid Cells
    Scientists found that a characteristic of cancer stem-like cells from chemoresistant tumors is the ability to produce a variety of proinflammatory cytokines and to generate M2-like immunoregulatory myeloid cells from CD14+ monocytes. [Cancer Res] Abstract
    Culture and Characterize Mouse Mammary Epithelial Progenitors with Serum-Free EpiCult-B (Mouse) Free Protocols

    PUBLICATIONS (Ranked by impact factor of the journal)
    Curcumin Promotes Autophagic Survival of a Sub-Set of Colon Cancer Stem Cells, which Are Ablated by DCLK1-siRNA
    Researchers report that curcumin promotes the survival of DCLK1-positive colon cancer stem-like cells, potentially confounding application of its anticancer properties. [Cancer Res] Abstract

    CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
    Investigators identified CD44v8-10 as the predominant CD44 variant expressed in gastric cancer cells and verified its role as a gastric cancer stem cell marker by limiting dilution and serial transplantation assays. [Cancer Res] Abstract

    Conversion of Differentiated Cancer Cells into Cancer Stem-Like Cells in a Glioblastoma Model after Primary Chemotherapy
    In order to understand glioma recurrence post therapy, the authors investigated the behavior of glioma stem cells (GSCs) after primary chemotherapy. They showed that exposure of patient-derived as well as established glioma cell lines to therapeutic doses of temozolomide, the most commonly used antiglioma chemotherapy, consistently increases the GSC pool over time both in vitro and in vivo. [Cell Death Differ] Abstract

    Selective Inhibition of Breast Cancer Stem Cells by Gold Nanorods Mediated Plasmonic Hyperthermia
    Researchers report gold nanorods mediated photothermal treatment can selectively eliminate cancer stem cells in MCF-7 breast cancer cells. It significantly reduced the aldehyde dehydrogenase positive cells subpopulation and the mammosphere formation ability of treated cells. [Biomaterials] Abstract

    Identification and Characterization of Cancer Stem Cells in Human Head and Neck Squamous Cell Carcinoma
    The authors previously identified a small population of CD24+/CD44+ cells in head and neck squamous cell carcinoma (HNSCC). They examined whether this population of cells may represent cancer stem cells in HNSCC. [BMC Cancer] Full Article

    The Selective Aurora-A Kinase Inhibitor MLN8237 (Alisertib) Potently Inhibits Proliferation of Glioblastoma Neurosphere Tumor Stem-Like Cells and Potentiates the Effects of Temozolomide and Ionizing Radiation
    Scientists investigated the effect of MLN8237 with and without temozolomide or ionizing radiation on the proliferation of glioblastoma tumor stem-like cells using soft agar colony formation assays and normal human astrocytes by MTT assay. [Cancer Chemother Pharmacol] Abstract

    Sulforaphane and TRAIL Induce a Synergistic Elimination of Advanced Prostate Cancer Stem-Like Cells
    Investigators examined the effects of sulforaphane and TRAIL on NF-κB activity, self-renewal and differentiation potential, and stem cell signaling via spheroid- and colony-forming assays, FACS and western blot analyses, immunohistochemistry, and an antibody protein array in vitro and after xenotransplantation. [Int J Oncol] Abstract | Download Full Article

    Downregulation of VEGF Expression Attenuates Malignant Biological Behavior of C6 Glioma Stem Cells
    The authors established C6 glioma stem cells (C6GSCs) from the C6 glioma cells. They suppressed the vascular endothelial growth factor (VEGF) expression of C6GSCs using lentiviral vector-VEGF shRNA. [Int J Oncol] Abstract

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    Contributions of Epithelial-Mesenchymal Transition and Cancer Stem Cells to the Development of Castration Resistance of Prostate Cancer
    New emerging evidences indicate that epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) play crucial roles during the development of castration-resistance and metastasis of prostate cancer. The authors review recent progress of EMT and CSCs in castration-resistant prostate cancer. [Mol Cancer]
    Full Article

    Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

    Cerulean Announces First Patient Dosed in Phase Ib/II Trial of CRLX101 in Combination with Chemotherapy and Radiation in Neoadjuvant Rectal Cancer
    Cerulean Pharma Inc. announced that the first patient has been dosed in a Phase Ib/II trial designed to identify the recommended Phase II dose of CRLX101 in combination with Xeloda® (capecitabine) and radiation (chemoradiotherapy) and detect signals, if any, of increased efficacy over standard neoadjuvant chemoradiotherapy for rectal cancer. [Cerulean Pharma Inc.] Press Release

    First Patient Enrolled in GenSpera G-202 Phase II Glioblastoma
    GenSpera, Inc. announced that the first patient was enrolled in the Phase II clinical trial of its lead compound, G-202, in patients who have glioblastoma multiforme, the most prevalent type of primary brain cancer. [GenSpera, Inc.] Press Release

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    Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
    The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer (D-CA) and Mark Kirk (R-IL). [Alliance for Regenerative Medicine] Press Release

    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

    NEW International Society for Stem Cell Research (ISSCR) 12th Annual Meeting
    June 18-21, 2014
    Vancouver, Canada

    Visit our events page to see a complete list of events in the cancer stem cell community.

    NEW Postdoctoral Fellow – Hematopoietic Stem Cell and Leukemia Research (City of Hope)

    Tenure-Track Faculty Position – Cancer Biology and Evolution (Moffitt Cancer Center)

    Postdoctoral Position – Glioblastoma, Oncolytic Virus and Cell Signaling (Ohio State University)

    Postdoctoral Research Fellow – Cancer Bioinformatics (Karolinska Institutet)

    Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

    Postdoctoral Scientist – Small Cell Lung Cancer Circulating Tumor Cell Derived Explant Tumor Models (Cancer Research UK Manchester Institute)

    Faculty Position – Cancer Biology and Evolution (Moffitt Cancer Center & Research Institute)

    Postdoctoral Position – Molecular Mechanisms of Cell Division (Memorial Sloan Kettering Cancer Center)

    Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

    Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

    Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

    Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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