Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression Researchers provide evidence that cancer stem cells (CSCs) selectively utilize the scavenger receptor CD36 to promote their maintenance using patient-derived CSCs and in vivo xenograft models. [Stem Cells] Abstract
Two Mature Products of MIR-491 Coordinate to Suppress Key Cancer Hallmarks in Glioblastoma miR-491-3p inhibited glioma cell invasion; overexpression of both miR-491-5p and -3p inhibited proliferation of glioma cell lines and impaired the propagation of glioma stem cells, thereby prolonging survival of xenograft mice. [Oncogene] Abstract
Tumor-Initiating Capacity Is Independent of Epithelial-Mesenchymal Transition Status in Breast Cancer Cell Lines Researchers determined whether epithelial-mesenchymal transition directly led to the acquisition of tumor-initiating capacity in breast cancer cell lines. [Br J Cancer] Abstract
Differentially Expressed miRNAs in Cancer Stem Like Cells: Markers for Tumor Cell Aggressiveness of Pancreatic Cancer Researchers showed that isolated CD44+/CD133+/EpCAM+ cells from human pancreatic cancer cell lines, MiaPaCa-2 and L3.6pl cells display aggressive characteristics such as increased cell growth, clonogenicity, cell migration, and self-renewal capacity, which is consistent with over-expression of cancer stem like cell signatures/markers. [Stem Cells Dev] Abstract
ARTEMIN, a Member of the Glial Cell Line-Derived Neurotrophic Factor Family of Ligands, Is HER2 Regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-Like Behavior in Mammary Carcinoma Cells Forced expression of ARTEMIN decreased the sensitivity of HER2 positive mammary carcinoma cells to Trastuzumab both in vitro and in vivo. Trastuzumab resistance produced an increased cancer stem cell population concomitant with enhanced mammospheric growth. [J Biol Chem] Abstract | Full Article
Evidence of Brain Tumor Stem Progenitor-Like Cells with Low Proliferative Capacity in Human Benign Pituitary Adenoma Researchers found that pituitary adenoma tissues expressed neural stem cell markers. These cells could form neurospheres in vitro, expressed neural stem/progenitor cell markers and generated daughter cells with the capacity to differentiate into three neural lineages. [Cancer Lett] Abstract
Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition Researchers demonstrated evidence that the role of maternal embryonic leucine-zipper kinase (MELK) in the glioma stem cell survival is specifically dependent on its kinase activity. [PLoS One] Full Article
MiR-330-Mediated Regulation of SH3GL2 Expression Enhances Malignant Behaviors of Glioblastoma Stem Cells by Activating ERK and PI3K/AKT Signaling Pathways Researchers identified miR-330 as a potential regulator of SH3GL2 and they found that it was to be inversely correlated with SH3GL2 expression in glioblastoma stem cells which were isolated from U87 cell lines. [PLoS One] Full Article
Large Cell Anaplastic Medulloblastoma Metastatic to the Scalp: Tumor and Derived Stem-Like Cells Features Researchers present the case of a child with large cell anaplastic medulloblastoma (MBL), who developed multiple subcutaneous metastases in the scalp area after a ventriculo-peritoneal shunting procedure. They molecularly classified the tumor as a group three MBL; in addition, they derived stem-like cells from a metastatic lesion. [BMC Cancer] Abstract | Full Article
DDX4 (DEAD Box Polypeptide 4) Colocalizes with Cancer Stem Cell Marker CD133 in Ovarian Cancers Scientists investigated the relationship between DDX4 and ovarian cancer stem cells by analyzing the expression patterns of DDX4 and the cancer stem cell marker CD133 in ovarian cancers via tissue microarray. [Biochem Biophys Res Commun] Abstract
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