Cancer Stem Cell News Volume 3.30 | Aug 6 2014

5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell-Like Cells in Acute Myeloid Leukemia
Scientists found that pharmacological inhibition of 5-lipoxygenase interfered strongly with the aberrant stem cell capacity of PML/RARα-expressing hematopoietic stem and progenitor cells. [Cancer Res]
Abstract | Press Release

Dynamics of Leukemia Stem-Like Cells Extinction in Acute Promyelocytic Leukemia
Researchers investigated the dynamics of acute promyelocytic leukemia before and during therapy with regard to disease initiation, progression and therapeutic response. [Cancer Res] Abstract

A Distinct DNA Methylation Signature Defines Breast Cancer Stem Cells and Predicts Cancer Outcome
Scientists used a whole genome promoter microarray to establish the DNA methylation portraits of breast cancer stem cells (bCSC) and non-bCSCs. [Stem Cells] Abstract

The Sonic Hedgehog Signaling Pathway Maintains the Cancer Stem Cell Self-Renewal of Anaplastic Thyroid Cancer by Inducing Snail Expression
Researchers used two anaplastic thyroid cancer cell lines as a model to study the role of the sonic hedgehog pathway in maintaining thyroid cancer stem cells self-renewal and to understand its underlying molecular mechanisms. [J Clin Endocrinol Metab] Abstract

Adult Mouse Subventricular Zones Stimulate Glioblastoma Stem Cells Specific Invasion through CXCL12/CXCR4 Signaling
Researchers questioned the role of the CXCL12/CXCR4 signaling in the glioblastoma stem cell-specific invasion of the subventricular zones. [Neuro Oncol] Abstract

Caveolin-1 Mediates Chemoresistance in Breast Cancer Stem Cells via β-Catenin/ABCG2 Signaling Pathway
Caveolin-1 silencing sensitized breast cancer stem cells (CSCs) by limiting their self-renewal ability but promoting the differentiation process. β-catenin silencing prevented the enhanced chemoresistance of CSCs induced by caveolin-1 overexpression, indicating that β-catenin is an essential molecule responsible for caveolin-1-mediated action. [Carcinogenesis] Abstract

The IL-8/CXCR1 Axis Is Associated with Cancer Stem Cell-Like Properties and Correlates with Clinical Prognosis in Human Pancreatic Cancer Cases
Functional studies confirmed that IL-8 addition increased sphere formation, cancer stem cell populations, and cell invasion of pancreatic cancer cells and that these effects could be reversed by antagonizing CXCR1 with a CXCR1-specific antibody. [Sci Rep] Full Article

Excessive Hyaluronan Production Promotes Acquisition of Cancer Stem Cell Signatures through the Coordinated Regulation of Twist and the TGF-β-Snail Signaling Axis
Scientists hypothesize that hyaluronan overproduction may accelerate cancer progression by expanding cancer stem cell (CSC) subpopulations during cancer development. Flow cytometric analysis demonstrated the enrichment of CD44^high/CD24^low CSC-like cells in the side population fraction of hyaluronan overproducing cancer cells. [J Biol Chem] Abstract | Full Article

MicroRNA-9 Is Associated with Epithelial-Mesenchymal Transition, Breast Cancer Stem Cell Phenotype, and Tumor Progression in Breast Cancer
Researchers evaluated the expression levels of microRNAs in human breast cancer samples and analyzed their relationship with clinicopathologic features of the tumor including breast cancer subtype, epithelial-mesenchymal transition, breast cancer stem cell phenotype, and prognosis. [Breast Cancer Res Treat] Abstract

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CEL-SCI Achieves Milestone with Total of 232 Patients Enrolled to Date in Its Phase III Head and Neck Cancer Trial
CEL-SCI Corporation announced that the company enrolled 14 patients with advanced primary, not yet treated, head and neck cancer into its global pivotal Phase III head and neck cancer trial for its investigational immunotherapy Multikine. [CEL-SCI Corporation] Press Release

AbbVie Receives EMA and FDA Orphan Drug Designation for Investigational Compound ABT-414 in the Treatment of Glioblastoma Multiforme
AbbVie announced the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA) have granted orphan drug designation to AbbVie’s investigational compound ABT-414, an anti-epidermal growth factor receptor antibody drug conjugate, which is being evaluated for safety and efficacy in patients with glioblastoma multiforme. [AbbVie Inc.] Press Release

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PhD Student – Cancer Stem Cells (KU Leuven)

Technical Account Manager (GlobalStem)

Postdoctoral Position – Molecular Properties of Leukemic Stem Cells (BC Cancer Agency)

PhD Candidate – Mammary Stem Cell Biology (University of Amsterdam)

Postdoctoral Research Associate – Cancer Stem Cell Biology (University of California, San Diego)

Postdoctoral Position – Stem Cells and Cancer (Brigham & Women’s Hospital – Harvard Medical School)

Research Assistant/Research Associate – Stem Cell and Cancer Biology (University of North Texas Health Science Center)

Postdoctoral Fellowships – Cancer Research (German Cancer Research Center [DKFZ])

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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