The Runx-PU.1 Pathway Preserves Normal and AML/ETO9a Leukemic Stem Cells In a mouse model of AML/ETO9a leukemia, disrupting the Runx binding sites resulted in decreased PU.1 levels. Leukemia onset was delayed and limiting dilution transplantation experiments demonstrated functional loss of leukemia initiating cells. [Blood] Abstract MYC Activates Stem-Like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism Scientists show that c-MYC expression levels have a differential impact on liver cancer stem cells (CSC) characteristics. At low levels, c-MYC activation led to increased proliferation and enhanced CSC properties including activation of reprogramming transcription factors and CSC marker expression, expansion of side population and acceleration of tumor growth upon subcutaneous transplantation into immunocompromised mice. [Cancer Res] Abstract Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging Researchers show that high levels of lipid droplets are a distinctive mark of cancer stem cells (CSCs) in colorectal (CR) cancer. This increased lipid content was clearly revealed by label free Raman spectroscopy and it directly correlates with well-accepted CR-CSCs markers as CD133 and Wnt pathway activity. [Stem Cells] Abstract Dietary Compound Isoliquiritigenin Targets GRP78 to Chemosensitize Breast Cancer Stem Cells via β-Catenin/ABCG2 Signaling Researchers investigated the chemosensitizing effects of isoliquiritigenin on breast cancer stem cells and the underlying mechanisms regulating the β-catenin pathway. [Carcinogenesis] Abstract TRPM7 Channels Regulate Glioma Stem Cell through STAT3 and Notch Signaling Pathways Researchers demonstrate that Notch and STAT3 pathways are down regulated in glioma cells grown in monolayer. Furthermore, phospho-STAT3, Notch target genes and cancer stem cell (CSC) markers were significantly higher in spheroid glioma CSCs when compared with monolayer cultures. [Cell Signal] Abstract Neurotensin Signaling Regulates Stem-Like Traits of Glioblastoma Stem Cells through Activation of IL-8/CXCR1/STAT3 Pathway Scientists show that neurotensin receptor 1 (NTSR1) is higher expressed in glioblastoma stem cells (GSCs) than their non-GSCs counterparts. Pharmacological blockade with SR48692 or lentivirus mediated knockdown of NTSR1 efficiently reduced the sphere-forming ability and expression of stem cell markers such as Nestin and Sox2 in GSCs isolated from glioblastoma cell line and glioblastoma tissues. [Cell Signal] Abstract A Mathematical-Biological Joint Effort to Investigate the Tumor-Initiating Ability of Cancer Stem Cells Researchers present a model describing the initial phase of ErbB2+ mammary cancer progression, which arises from a joint effort combing mathematical modeling and cancer biology. The proposed model represents a new approach to investigate the cancer stem cells-driven tumorigenesis and to analyze the relations among crucial events involving cancer cell subpopulations. [PLoS One] Full Article Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas Using RNA in situ hybridization and antibody tools capable of detecting multiple isoforms of prominin-1 (Prom1), researchers found evidence for two distinct Prom1 cell populations in mouse brain. Prom1 RNA is first expressed in stem/progenitor cells of the ventricular zone in embryonic brain. [PLoS One] Full Article ABCG2 Regulates the Pattern of Self-Renewing Divisions in Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Researchers demonstrated that ABCG2 is involved in the cell division of drug-resistant cancer cells. They established drug-resistant H460 and A549 cell lines by repeated exposure to cisplatin and found that the expression of ABCG2 in these cell lines was significantly increased. [Oncol Rep] Abstract |