Parthenolide Inhibits Cancer Stem-Like Side Population of Nasopharyngeal Carcinoma Cells via Suppression of the NF-κB/COX-2 Pathway Cyclooxygenase-2 (COX-2) was found to regulate cancer stem-like side population cells of nasopharyngeal carcinoma cells and enhance cancer stem-like cells’ characteristics such as higher colony formation efficiency and overexpression of stemness-associated genes. [Theranostics] Full Article Morusin Inhibits Glioblastoma Stem Cell Growth In Vitro and In Vivo through Stemness Attenuation, Adipocyte Transdifferentiation, and Apoptosis Induction The authors researched the growth inhibition effect of morusin on human glioblastoma multiforme cancer stem cells growth in vitro and in vivo and explored the possible mechanism of its activity. [Mol Carcinog] Abstract Divergent Roles of CXCR3 Isoforms in Promoting Cancer Stem-Like Cell Survival and Metastasis Investigators employed primary invasive ductal carcinomas, a panel of breast cell lines, and a xenograft model of metastatic breast cancer to examine the role of CXCR3 isoforms in the behavior of breast cancer stem-like cells and the contribution of each isoform to metastasis. [Breast Cancer Res Treat] Abstract GRP78/BiP/HSPA5/Dna K Is a Universal Therapeutic Target for Human Disease OSU-03012/sildenafil treatment killed brain cancer stem cells and decreased the expression of: NPC1 and TIM1; LAMP1; and NTCP1, receptors for Ebola/Marburg/Hepatitis A, Lassa fever, and Hepatitis B viruses, respectively [J Cell Physiol] Abstract | Full Article | Press Release Cancer Stem-Like Cells of Ovarian Clear Cell Carcinoma Are Enriched in the ALDH-High Population Associated with an Accelerated Scavenging System in Reactive Oxygen Species Researchers investigated the relationship between a cancer stem-like cell marker, aldehyde dehydrogenase 1 (ALDH1), and clinical prognosis using ovarian clear cell carcinoma tissue samples. [Gynecol Oncol] Abstract Selective Lentiviral Gene Delivery to CD133-Expressing Human Glioblastoma Stem Cells Scientists present CD133-LV, a lentiviral vector presenting a single chain antibody against CD133 on its envelope, as a vehicle for the selective transduction of CD133-expressing glioblastoma stem cells. [PLoS One] Full Article Immunophenotypic Characterization of Human Glioblastoma Stem Cells: Correlation with Clinical Outcome The authors evaluated the prognostic potential of ability to generate glioblastoma stem cells (GSCs) in their series of 15 glioblastoma patients. β-tubulin III, nestin, CD133, GFAP and SOX-2 marker expression, both in primary glioblastoma multiforme cultures and in respective GSCs, was evaluated by flow cytometric analysis. [J Cell Biochem] Abstract Targeting CD133 in the Enhancement of Chemosensitivity in Oral Squamous Cell Carcinomas-Derived Side Population Cancer Stem Cells Investigators determined the function of CD133 on chemosensitivity of oral squamous cell carcinoma-cancer stem cells (OSCC-CSCs) by silencing CD133. They observed that the expression profile of CD133 in OSCC-side population cells, which exerted properties of CSCs, was significantly up-regulated than that of major population cells of OSCCs. [Head Neck] Abstract Cancer Stem Cell Marker in Circulating Tumor Cells: Expression of CD44 Variant Exon 9 Is Strongly Correlated to Treatment Refractoriness, Recurrence and Prognosis of Human Colorectal Cancer The expression of the CD44 variant exon 9 was investigated in order to elucidate its significance for cancer stem cells in circulating human colorectal cancer cells. [Anticancer Res] Abstract |