Small Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-Like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner Researchers hypothesized that the potent anti-tumor effect of ONC201/TIC10 in colorectal cancer involves targeting cancer stem/progenitor cells (CSCs) and bulk tumor cells. ONC201/TIC10 significantly reduced CSC-initiated xenograft tumor growth in mice and prevented the passage of these tumors. [Cancer Res] Abstract Hyperthermia Sensitizes Glioma Stem-Like Cells to Radiation by Inhibiting AKT Signaling Scientists investigated the mechanisms of hyperthermic radiosensitization in glioma stem-like cells by a phospho-kinase array that revealed the survival kinase AKT as a critical sensitization determinant. [Cancer Res] Abstract Radiosensitization of Primary Human Glioblastoma Stem-Like Cells with Low-Dose AKT Inhibition Scientists demonstrate that in primary glioblastoma (GBM) tumor samples, full-dose inhibition of AKT activity leads to differential responses among samples in the context of cell death and self- renewal, reinforcing the notion that GBM is a heterogeneous disease. [Mol Cancer Ther] Abstract Enhancing HOTAIR/MiR-10b Drive Liver Normal Stem Cells to Arise Malignant Transformation Tendency through Inducing Epithelial-Mesenchymal Transitions After microRNA-10b and HOTAIR were separately enhanced, several cancer stem cell-like traits appeared in the liver normal stem cells, such as in vitro enhanced proliferative capacity, expression of putative liver cancer stem cells markers, progressed obtainment of invasive ability, and even in vivo aggravation into and taking place of normal liver tissue. [Rejuvenation Res] Abstract Dicer Regulated Let-7 Expression Levels in p53-Induced Cancer Repression Requires Cyclin D1 Researchers found that let-7 miRNA expression decreased because of the p53-induced cell death response with deregulated cyclin D1. Their results also showed that cyclin D1 is required for altered Nutlin-3- and TAX-induced let-7 expression in cancer repression and the cell death response. [J Cell Mol Med] Full Article Natural Grape Extracts Regulate Colon Cancer Cells Malignancy Liofenolâ„¢ induced an important morphology change in HCT116 cells, migration inhibition, undifferentiated stem/stem-like cells markers downregulation, and E-cadherin downregulation, interested in epithelia to mesenchymal malignant transition. [Nutr Cancer] Abstract Prognostic Significance of CD44v6, CD133, CD166, and ALDH1 Expression in Small Intestinal Adenocarcinoma CD44v6, CD133, CD166, and ALDH1 have been proposed to be putative cancer stem cell markers in gastrointestinal malignancies. Researchers investigated the expressions of CD44v6, CD133, CD166, and ALDH1 and evaluated their relationships with clinicopathologic parameters including the survival data in small intestinal adenocarcinoma. [Appl Immunohistochem Mol Morphol] Abstract A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland CXCR4 Function in Mammary Progenitors Scientists demonstrate that CXCR4, the receptor for stromal-derived factor 1, is a crucial instructor of hormone-induced mammary stem and progenitor cell function and present a new avenue for potentially targeting progenitor cell growth and malignant transformation in breast cancer. [Stem Cell Rep] Full Article | Graphical Abstract |