Cancer Stem Cell News Volume 4.22 | June 10 2015

Glioma Initiating Cells Contribute to Malignant Transformation of Host Glial Cells during Tumor Tissue Remodeling via-PDGF Signaling
The interactions between glioma initiating cells (GICs) and host cells in vivo were observed during tissue remodeling processes initiated by human GICs. [Cancer Lett] Abstract

CD15 Expression Does Not Identify a Phenotypically or Genetically Distinct Glioblastoma Population
Scientists demonstrated that CD15-positive (CD15⁺) cells were less proliferative than their CD15-negative (CD15⁻) counterparts in 10 patient glioblastoma (GB) tumors. They also compared the proliferative activity of CD15⁺ and CD15⁻ cells in vitro using tumor-initiating primary GB cell lines and found no difference in proliferative behavior. [Stem Cells Transl Med] Abstract

A Versatile Mathematical Work-Flow to Explore How Cancer Stem Cell Fate Influences Tumor Progression
Researchers extended their recent model on cancer stem cell-dynamics creating a new system capable of describing tumor growth during the different stages of cancer progression. [BMC Syst Biol] Full Article

Resveratrol Inhibits the Invasion of Glioblastoma-Initiating Cells via Down-Regulation of the PI3K/Akt/NF-κB Signaling Pathway
Investigators evaluated whether resveratrol (RES) can inhibit glioblastoma-initiating cells (GICs) invasion in vitro and in vivo. They demonstrated that RES suppressed the adhesion, invasion and migration of GICs in vitro and in vivo. [Nutrients] Full Article

Enhancement of SOX-2 Expression and ROS Accumulation by Culture of A172 Glioblastoma Cells under Non-Adherent Culture Conditions
The authors compared the effects of differently textured culture plates and serum deprivation on the acquisition of cancer stem cell properties of A172 glioblastoma cells. [Oncol Rep] Abstract

Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes
Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated. ALDH1 and CD133 had higher expression levels in the NSCLC compared to the SCLC. [Cancer Invest] Abstract

Kruppel-Like Factor 4 Signals through MicroRNA-206 to Promote Tumor Initiation and Cell Survival
Scientists found that both kruppel-like factor 4 and a downstream effector, microRNA-206, are selectively enriched in the mammary cancer stem-like cells (MaCSCs) fractions of cultured human triple negative breast cancer cell lines, as well as in the aldehyde dehydrogenase-high MaCSC sub-population of cells derived from xenografted human mammary carcinomas. [Oncogenesis] Full Article

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Sanford Consortium, Takeda Pharmaceutical Partner in $10-Million “Innovation Alliance”
The Sanford Consortium for Regenerative Medicine and the Takeda Pharmaceutical Company Limited have agreed to establish a $10-million, five-year Innovation Alliance that would advance each organization’s research missions. [UC San Diego] Press Release

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