Targeting Phospholipase D1 Attenuates Intestinal Tumorigenesis by Controlling β-Catenin Signaling in Cancer-Initiating Cells Researchers showed that genetic and pharmacological targeting of phospholipase D1 (PLD1) disrupts spontaneous and colitis-associated intestinal tumorigenesis in ApcMin/+ and azoxymethane/dextran sodium sulfate mice models. PLD1 inactivation suppressed the self-renewal capacity of colon cancer-initiating cells by decreasing expression of β-catenin via E2F1-induced microRNA-4496 up-regulation. [J Exp Med] Abstract Drug-Eluting Microarrays to Identify Effective Chemotherapeutic Combinations Targeting Patient-Derived Cancer Stem Cells To address the challenge of screening drug libraries on patient-derived populations of rare cells, such as cancer stem cells, investigators developed a drug-eluting microarray, a miniaturized platform onto which a minimal quantity of cells can adhere and be exposed to unique treatment conditions. [Proc Natl Acad Sci USA] Abstract | Press Release Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-Like Cell Traits in Breast Cancer Scientists report that metadherin (MTDH) drives cancer stem cell expansion by promoting the expression of TWIST1, a transcription factor critical for cancer cell stemness and metastasis. [Cancer Res] Abstract IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHHICD126+-Like Component and Reduces Tumor Burden Researchers hypothesized that high level of aldehyde dehydrogenase (ALDH) activity in a tumor might positively correlates with the presence of stem- and progenitor-like tumor cells in the disease setting of solid and hematopoietic cancers. [Cancer Res] Abstract | Full Article Cytomegalovirus Infection Induces a Stem Cell Phenotype in Human Primary Glioblastoma Cells: Prognostic Significance and Biological Impact Scientists investigated the relation between human cytomegalovirus (HCMV) infection of glioblastoma (GBM) cells and the presence of glioma cancer stem cells (GSCs). Infection of GBM cells with HCMV led to upregulation of CD133 and other GCS markers (Notch1, Sox2, Oct4, Nestin). [Cell Death Differ] Abstract mPGES-1 in Prostate Cancer Controls Stemness and Amplifies EGFR-Driven Oncogenicity Researchers investigated whether expression of intrinsic microsomal PGE synthase-1 (mPGES-1) enhanced aggressiveness of prostate cancer cells and might be critical for epidermal growth factor receptor (EGFR)-mediated tumor progression. DU145 and PC-3 cell lines expressing mPGES-1 expressed stem-cell-like features as well as mesenchymal transition markers. [Endocr-Relat Cancer] Abstract Metabolic Stress Induces a Wnt-Dependent Cancer Stem Cell-Like State Transition Scientists demonstrated that chronic metabolic stress in a long-term nutrient deprivation induces a Wnt-dependent phenoconversion of non-stem cancer cells toward stem-like state and this is reflected in the transcriptome analysis. [Cell Death Dis] Full Article Identification of Thiostrepton as a Novel Therapeutic Agent that Targets Human Colon Cancer Stem Cells The authors investigated thiostrepton’s inhibitory effects on the sphere- and colony-forming capabilities of colorectal cancer cell lines. The in vitro inhibition of sphere and colony formation was associated with downregulation of various modulators of the stem cell phenotype. [Cell Death Dis] Full Article BMP-2 Induces Motility and Invasiveness by Promoting Colon Cancer Stemness through STAT3 Activation Researchers investigated the role of bone morphogenetic proteins (BMP)-2 in colon cancer stem cell (CSC) development from colon cancer cells. They also determined the effects of BMP-2 on CSC development and epithelial-mesenchymal transition in human colon cancer cell lines HCT-116 and SW620. [Tumor Biol] Abstract Cardamonin Induces Apoptosis by Suppressing STAT3 Signaling Pathway in Glioblastoma Stem Cells Scientists investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on the self-renewal and apoptosis of glioblastoma stem cells (GSCs), and if its action was associated with signal transducer and activator of transcription 3 (STAT3) pathway. [Tumor Biol] Abstract |