The Mitotic Kinesin KIF11 Is a Driver of Invasion, Proliferation, and Self-Renewal in Glioblastoma Inhibition of KIF11 with a highly specific small-molecule inhibitor stopped the growth of the more treatment-resistant glioblastoma tumor-initiating cells (TICs) as well as non-TICs and impeded tumor initiation and self-renewal of the TIC population. [Sci Transl Med] Abstract Long Noncoding RNA CUDR Regulates HULC and β-Catenin to Govern Human Liver Stem Cell Malignant Differentiation The authors provide the first demonstration that CUDR plays a positive potential role in liver cancer stem cell through the cascade of CUDR-HULC/CUDR-β-catenin signaling, and offer insights into a novel link between lncRNA and the epigenetic modification in cancer stem cells. [Mol Ther] Abstract Carbon Ion Beam Combined with Cisplatin Effectively Disrupts Triple Negative Breast Cancer Stem-Like Cells In Vitro Human breast cancer stem-like cells sorted from MDA-MB-231 and MDA-MB-453 cells were treated with a carbon ion beam or X-ray irradiation alone or in combination with cisplatin, and then colony, spheroid and tumor formation assays, RT-PCR Array analysis, and immunofluorescence γH2AX foci assay were performed. [Mol Cancer] Full Article Osteosarcoma Stem Cells Have Active Wnt/β-Catenin and Overexpress SOX2 and KLF4 Investigators showed that different cancer stem cell populations may co-exist in osteosarcoma cell lines exhibiting distinct functional properties. Osteosarcoma spheres are slowly-proliferating populations, overexpress SOX2 and KLF4 stemness-related genes and have enhanced tumorigenic potential. [J Cell Physiol] Abstract A Quantitative Proteomics Analysis of MCF7 Breast Cancer Stem and Progenitor Cell Populations Researchers used cancer stem cell (CSC) markers to isolate pure breast CSCs fractions and the mature luminal cells from the MCF7 cell line. Proteomic analysis was performed on these samples and a total of 3,304 proteins were identified. [Proteomics] Abstract PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity but Selects Cancer Stem Cells, Involving Autophagy The authors focused on how protein kinase C (PKC)δ regulates proliferation and cancer stem cell properties of the hormone-independent mammary cancer cell line LM38-LP, using pharmacological and genetic approaches. They found that pharmacological inhibition of PKCδ, by Rottlerin treatment, impairs in vitro LM38-LP proliferation through cell cycle arrest, inducing the formation of cytoplasmic-vacuoles. [J Cell Biochem] Abstract Lentivirus-Mediated shRNA Targeting Nanog Inhibits Cell Proliferation and Attenuates Cancer Stem Cell Activities in Breast Cancer Scientists report that Nanog was highly expressed in cancer stem cell-enriched population from breast cancer cells, as well as stemness-associated genes. They found that targeted inhibition of Nanog could suppress proliferation and colony formation in breast cancer cells. [J Drug Target] Abstract _645x110.jpg) |