Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes Researchers examined the potential of adult lineage-restricted progenitors to induce fully penetrant glioblastoma multiforme using CNS progenitor-specific inducible Cre mice to mutate Nf1, Trp53, and Pten. [Cancer Cell] Abstract Genome-Wide Screen Identified let-7c/miR-99a/miR-125b Regulating Tumor Progression and Stem-Like Properties in Cholangiocarcinoma Researchers found that enforced expression of let-7c, microRNA (miR)-99a or miR-125b could reduce the activity of signal transducer and activator 3 and further suppress cholangiocarcinoma (CCA) tumorigenicity in vivo and inhibit the migration and invasion of CCA cells in vitro. [Oncogene] Full Article ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy Scientists report that ER-stress-induced activation of the unfolded protein response forces colon-cancer stem cells to differentiate, resulting in their enhanced sensitivity to chemotherapy in vitro and in vivo. [Cell Rep] Full Article | Graphical Abstract Functional and Molecular Characterization of Cancer Stem-Like Cells in Bladder Cancer: A Potential Signature for Muscle-Invasive Tumors The authors isolated and characterized bladder cancer stem cells making use of different functional and molecular approaches. The data obtained provide strong evidence that muscle-invasive bladder cancer is enriched with a heterogeneous stem-like population characterized by enhanced chemoresistance and tumor initiating properties, able to recapitulate the heterogeneity of the original tumor. [Oncotarget] Full Article PI3K/AKT/mTOR and Sonic Hedgehog Pathways Cooperate Together to Inhibit Human Pancreatic Cancer Stem Cell Characteristics and Tumor Growth Scientists examined the efficacy of combining NVP-LDE-225 and NVP-BEZ-235 on pancreatic cancer stem cells characteristics, microRNA regulatory network, and tumor growth. [Oncotarget] Full Article Obesity Promotes Colonic Stem Cell Expansion during Cancer Initiation Researchers assessed the effects of high fat feeding on colonic stem cell maintenance during cancer initiation and the responsiveness of stem cells to adipokine signaling pathways. [Cancer Lett] Abstract Clinical Influence of Cancer Stem Cells on Residual Disease after Preoperative Chemoradiotherapy for Rectal Cancer The authors evaluated the clinical influence of cancer stem cells on residual disease after preoperative chemoradiotherapy (CRT) in patients with rectal cancer. The surgical specimens of 145 patients with residual rectal cancer after preoperative CRT were assessed. [Tumor Biol] Abstract Ideal Sphere-Forming Culture Conditions to Maintain Pluripotency in a Hepatocellular Carcinoma Cell Lines Investigators identified and validated optimal culture conditions for sphere formation in hepatocellular carcinoma cells. Huh7 and HepG2 cells were plated in three different media types and were allowed to form spheres. [Cancer Cell Int] Full Article ![[Free On-Demand Webinar] Detect Cancer Stem Cells with ALDEFLUORâ„¢ - Watch Now.](http://img.en25.com/eloquaimages/clients/StemcellTechnologiesInc/{87cda00f-ac85-49b9-866e-b67e0756b6b7}_ON393_VerA-Aldefluor_CSC_webinar_A_645x110.jpg) |