Cancer Stem Cell News Volume 4.42 | Nov 4 2015

Targeting Stemness Is an Effective Strategy to Control EML4-ALK⁺ Non-Small Cell Lung Cancer Cells
The authors report that stem-like properties stem from anaplastic lymphoma kinase (ALK) activity in echinoderm microtubule-associated protein-like 4 (EML4)-ALK⁺ non-small cell lung carcinoma cells. [Oncotarget] Full Article

Bub1 Is Required for Maintaining Cancer Stem Cells in Breast Cancer Cell Lines
Scientists identified that depleting Bub1 (budding uninhibited by benzimidazoles 1) using shRNAs reduces cancer stem cell potential of the MDA-MB-231 breast cancer cell line, resulting in inhibited formation of xenografts in immunocompromised mice. [Sci Rep] Full Article

A Paired Comparison between Glioblastoma ‘Stem Cells’ and Differentiated Cells
Researchers compared key features of three pairs of glioblastoma cell populations, each pair consisting of stem cell-like and differentiated cells derived from an individual patient. [Int J Cancer] Abstract

Tumor Cell-Derived Periostin Regulates Cytokines that Maintain Breast Cancer Stem Cells
Scientists hypothesized that basal-like breast cancer (BLBC) cells are able to establish a niche permissive to the maintenance of cancer stem cells (CSCs) and found that tumor cell-derived periostin, a component of the extracellular matrix, as well as a corresponding cognate receptor, integrin alphavbeta3, are highly expressed in a subset of BLBC cell lines as well as in CSC-enriched populations. [Mol Cancer Res] Abstract

Stem Cell Protein Piwil1 Endowed Endometrial Cancer Cells with Stem-Like Properties via Inducing Epithelial-Mesenchymal Transition
Scientists suggest that stem cell protein Piwil1 plays important roles in regulating epithelial-mesenchymal transition and the acquisition of stem-like properties of endometrial cancer cells. [BMC Cancer] Full Article

Salinomycin Promotes Anoikis and Decreases the CD44⁺/CD24^– Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells
Researchers investigated the effect of salinomycin on cell death, migration, and invasion, as well as cancer stem cell-like properties in MDA-MB-231 breast cancer cells. [PLoS One] Full Article

Metformin and Soybean-Derived Bioactive Molecules Attenuate the Expansion of Stem Cell-Like Epithelial Subpopulation and Confer Apoptotic Sensitivity in Human Colon Cancer Cells
To investigate the actions of metabolic regulators on cancer stem cell-like cells (CSC) in colorectal cancer, investigators determined the effects of soybean-derived bioactive molecules and the anti-diabetes drug metformin, alone and together, on the growth, survival, and frequency of CSC in human HCT116 cells. [Genes Nutr] Abstract

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TSRI Team Wins $1.8 Million to Study Early Events in Cancer Metastasis
Scientists at The Scripps Research Institute (TSRI) have been awarded a grant of more than $1.8 million from the National Institutes of Health’s National Cancer Institute to investigate the molecular machinery involved in metastasis. [The Scripps Research Institute] Press Release

MD Anderson’s Moon Shots Mission Grows to Confront Six More Cancer Types
MD Anderson’s Moon Shots Program, an unprecedented effort and novel organizational model designed to more rapidly convert scientific discoveries into life-saving advances, has expanded its targets, adding several of the most intractable cancers to its campaign. [The University of Texas MD Anderson Cancer Center] Press Release

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Group Leader Position – Cancer Research (Oslo University Hospital)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

PhD Studentships – Cancer Research (University of Cambridge)

Assistant, Associate or Full Professor – Hematopoietic Stem Cell Biology (Mayo Clinic)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Stem Cell, Developmental, and Cancer Biology (University of California Santa Cruz)

Postdoctoral Positions – Stem Cell, Developmental, and Cancer Biology (Columbia University Medical Center)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Fellow – Cancer Biology (National Cancer Institute)

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