Cancer Stem Cell News Volume 5.03 | Jan 27 2016


    Cancer Stem Cell News 5.03 January 27, 2016

    Cancer Stem Cell News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    The Novel Tumor Suppressor Madm Regulates Stem Cell Competition in the Drosophila Testis
    Researchers identified Mlf1-adaptor molecule (Madm), a novel tumor suppressor that regulates the competition between germline stem cells and somatic cyst stem cells for niche occupancy. [Nat Commun] Full Article
    Request your Free Wallchart on Naive and Primed Stem Cell States

    PUBLICATIONS (Ranked by impact factor of the journal)
    Long Non-Coding RNA DILC Represses Self-Renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis
    Depletion of lncRNA down-regulated in liver cancer stem cells (lnc-DILC) markedly enhanced liver cancer stem cell (LCSC) expansion and facilitated HCC initiation and progression, whereas ectopic expression of lnc-DILC dramatically inhibited LCSC expansion. Mechanistically, lnc-DILC inhibited the autocrine interleukine-6 (IL-6)/STAT3 signaling. [J Hepatol] Abstract

    VEGF-A Acts via Neuropilin-1 to Enhance Epidermal Cancer Stem Cell Survival and Formation of Aggressive and Highly Vascularized Tumors
    Researchers showed that epidermal cancer stem cell-produced vascular endothelial growth factor (VEGF)-A is required for the maintenance of this phenotype, as knockdown of VEGF-A gene expression or treatment with VEGF-A-inactivating antibody reduces these responses. [Oncogene] Abstract

    Inhibition of FOXC2 Restores Epithelial Phenotype and Drug Sensitivity in Prostate Cancer Cells with Stem-Cell Properties
    Scientists identified a critical nexus between p38MAPK signaling, and the transcription factor Forkhead Box Protein C2 (FOXC2) known to promote cancer stem-cells and metastasis. [Oncogene] Full Article

    Let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex
    Investigators demonstrated a chromatin-dependent mechanism of let-7 in regulating target gene expression in cancer cells. Let-7 directly represses the expression of AT-rich interacting domain 3B (ARID3B), ARID3A, and importin-9. [Cell Rep] Full Article | Graphical Abstract

    Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism
    Researchers isolated cancer stem cells (CSCs) through sphere culture of A2780, SKOV3, OVCAR3 epithelial ovarian cancer cells and primary ovarian cancer cells from patients. They identified heat-stable factors secreted from ovarian CSCs stimulated migration and proliferation of CSCs. [Stem Cells] Abstract

    Plumbagin, a Naphthaquinone Derivative Induces Apoptosis and in BRCA 1/2 Defective Castrate Resistant Prostate Cancer Cells as Well as Prostate Cancer Stem-Like Cells
    Scientists aimed to analyze the molecular changes elicited by plumbagin (PB) and some closely related quinones in BRCA1/2 silenced prostate cancer (PCa) cells. Specific inhibitory effect of PB on PCa Stem-Like Cell population is also revealed in this study. [Pharmacol Res] Abstract

    Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells
    Researchers examined the expression and role of fatty acid synthase, a key lipogenic enzyme, in glioma stem cells (GSCs). In the de novo lipid synthesis assay, GSCs exhibited higher lipogenesis than differentiated non-GSCs. [PLoS One] Full Article

    Histological Characterization of the Tumorigenic “Peri-Necrotic Niche” Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma
    Scientists examined human astrocytoma tissues for hypoxia-inducible factor-1α-regulated quiescent stem-like tumor cells as a candidate for long-term tumorigenic cells and characterized their niche histologically. [PLoS One] Full Article

    Induction of Protumoral CD11chigh Macrophages by Glioma Cancer Stem Cells through GM-CSF
    Using rat C6 glioma side population cells as a model of glioma cancer stem cells (CSCs), investigators showed that CSCs induce tumor-associated macrophages development by promoting survival and differentiation of bone marrow-derived monocytes. [Genes Cells] Abstract

    Endocytosis and Serpentine Filopodia Drive Blebbishield-Mediated Resurrection of Apoptotic Cancer Stem Cells
    Investigators demonstrated that endocytosis drives serpentine filopodia to construct blebbishields from apoptotic bodies and that a VEGF-VEGFR2-endocytosis-p70S6K axis governs subsequent transformation. [Cell Death Discov] Full Article

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    Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches
    The authors analyze the potential metabolic targeting strategies for eradicating cancer stem cells that could help to develop a more effective therapeutic approach for gastrointestinal cancers. [J Cell Physiol] Abstract

    Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

    ImmunoCellular Therapeutics Enters into a Sponsored Research Agreement with The University of Maryland, Baltimore to Pursue Multiple Enhancements of its Cancer Immunotherapy Platforms
    ImmunoCellular Therapeutics, Ltd. announced it has entered into a sponsored research agreement with Eduardo Davila, PhD, Associate Professor of Microbiology and Immunology at the University of Maryland School of Medicine, and the University of Maryland, Baltimore. [ImmunoCellular Therapeutics, Ltd.] Press Release

    BIND Therapeutics Provides Enrollment Update for Phase II iNSITE 1 and iNSITE 2 Trials with BIND-014
    BIND Therapeutics, Inc. announced that the iNSITE 1 trial in non-small cell lung cancer with squamous histology is fully enrolled and data is expected to be available by the end of the first quarter of 2016. [BIND Therapeutics, Inc.] Press Release

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    National Institutes of Health (United States)

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    Therapeutic Goods Administration (Australia)

    NEW The Controlling Cancer Summit 2016
    May 17-19, 2016
    London, United Kingdom

    Visit our events page to see a complete list of events in the cancer stem cell community.

    NEW Post-Doc Fellowships – Integrative Analysis in Prostate and Breast Cancer (Baylor College of Medicine)

    NEW Research Scientist – Hematopoietic Stem Cell Transplantation (University of Chicago)

    NEW Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)

    Post-Doc Fellowship – Bioinformatics RNA Biology and Cancer (German Cancer Research Center)

    Post-Doc Fellowship – Genetics and Genomics of Stem Cells (Albert Einstein College of Medicine of Yeshiva University)

    Tenure Track Professorship – Tumor Biology and Signal Transduction (University Medical Center Gottingen)

    Professor – Cancer Immunotherapy (Stanford Cancer Institute)

    Postdoctoral Scientist – Follicular Lymphoma (Herbert Irving Comprehensive Cancer Center)

    Postdoctoral Researcher – Prostate Cancer Biology (Roswell Park Cancer Institute)

    Postdoctoral Fellow – Cell and Molecular Biology of Leukemia (Virginia Commonwealth University)

    Postdoctoral Fellow – Cancer Stem Cell Biology (Cleveland Clinic)

    Postdoctoral Position – Immunotherapy Targeting Cancer Stem Cells (Ecole Polytechnique Fédérale de Lausanne)

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