A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo The authors described a three-dimensional culture system that supports the long-term growth and expansion of tumor organoids derived directly from glioblastoma specimens, including patient-derived primary cultures, xenografts, genetically engineered glioma models, or patient samples. [Cancer Res] Abstract Epigenetic Modulation of a miR-296-5p:HMGA1 Axis Regulates Sox2 Expression and Glioblastoma Stem Cells Scientists identified a novel epigenetically regulated circuit that integrates microRNA, chromatin remodeling and the reprogramming transcription factor Sox2 to regulate glioblastoma-propagating stem cells. [Oncogene] Abstract SREBP-2 Promotes Stem Cell-Like Properties and Metastasis by Transcriptional Activation of c-Myc in Prostate Cancer The authors showed that expression of SREBP-2 was elevated in advanced pathologic grade and metastatic prostate cancer (PCa) and significantly associated with poor clinical outcomes. Biofunctional analyses demonstrated that SREBP-2 induced PCa cell proliferation, invasion and migration. [Oncotarget] Full Article Cucurbitacin B Inhibits the Stemness and Metastatic Abilities of NSCLC via Downregulation of Canonical Wnt/β-Catenin Signaling Axis The authors determined the anti-metastatic and anti-angiogenic potential of a natural plant triterpenoid, cucurbitacin B against non-small cell lung cancer (NSCLC) both in vitro and in vivo. [Sci Rep] Full Article Key Role of MEK/ERK Pathway in Sustaining Tumorigenicity and In Vitro Radioresistance of Embryonal Rhabdomyosarcoma Stem-Like Cell Population Researchers aimed to investigate the role of the MEK/ERK pathway in controlling the cancer stem-like phenotype using a model of rhabdospheres derived from the embryonal rhabdomyosarcoma cell line. [Mol Cancer] Full Article Prolonged Pemetrexed Pretreatment Augments Persistence of Cisplatin-Induced DNA Damage and Eliminates Resistant Lung Cancer Stem-Like Cells Associated with EMT Prolonged pemetrexed pretreatment for 48 hour prior to cisplatin treatment maximally delayed long-term cell growth and significantly reduced the number of recovering clones. Moreover, apoptosis and senescence were augmented and recovery from treatment-induced DNA damage was delayed. [BMC Cancer] Full Article Radiotherapy Diagnostic Biomarkers in Radioresistant Human H460 Lung Cancer Stem-Like Cells Scientists identified eight proteins that were up-regulated in RR-H460 cancer stem cells (CSCs) lines and therefore potentially involved in radioresistance and CSC-related biological processes. Notably, four of these-PAI-2, NOMO2, KLC4, and PLOD3-have not been previously linked to radioresistance. [Cancer Biol Ther] Abstract Suppression of Prostate Cancer Progression by Cancer Cell Stemness Inhibitor Napabucasin Decrease in cell viability, colony formation, migration, and survival with cell cycle arrest, higher sensitivity to docetaxel in vitro, and repressed tumorigenesis in vivo was observed upon napabucasin treatment. More importantly, napabucasin can inhibit spherogenesis and even kill prostate cancer stem cells in vitro. [Cancer Med] Full Article Inhibition of Monocarboxylate Transporter 1 Suppresses the Proliferation of Glioblastoma Stem Cells Based on the hypothesis that ion transport-related molecules regulate the viability and function of cancer stem cells (CSCs), the authors investigated the expression of ion transport-related molecules in glioblastoma CSCs. [J Physiol Sci] Abstract |