|Cancer Stem Cell News 5.26 July 6, 2016
Cancer stem-like cells (CSC) are thought to drive brain cancer but their cellular and molecular origins remain uncertain. Researchers report the successful generation of induced CSC from primary human astrocytes through the expression of defined genetic factors. [Cancer Res]
Investigators showed that ephrin-B2 mediates glioblastoma stem-like cells (GSC) perivascular invasion. Intravital imaging, coupled with mechanistic studies in murine glioblastoma models and patient-derived GSC, revealed that endothelial ephrin-B2 compartmentalizes non-tumorigenic cells. [eLife]
Scientists identified a population of long-term tumor-propagating cells in a mouse model of small cell lung cancer (SCLC). This population, marked by high levels of EpCAM and CD24, was also prevalent in human primary SCLC tumors. [Cell Rep]
HepG2-derived induced pluripotent stem cell-like cells were generated by introducing Yamanaka factors and the knockdown vector shTP53. They exhibited features of stemness and a higher tumorigenesis after xenograft transplantation compared with HepG2 cells. [Stem Cells]
Efficacy of photon and carbon ion irradiation with addition of cetuximab was studied on clonogenic death, migration and invasion of two HNSCC populations: SQ20B and SQ20B/cancer stem cells. SQ20B expressed E-cadherin and overexpressed epidermal growth factor receptor (EGFR) while SQ20B/cancer stem cells expressed N-cadherin and low EGFR. [Oncotarget]
IKK is a protein kinase that is composed of IKKα, IKKβ, IKKγ. The authors demonstrated that IKKα plus IKKβ promoted and IKKγ inhibited liver cancer stem cell growth in vitro and in vivo. [Oncotarget]
Scientists identified MAPK-interacting kinases (MNKs) as potential targets for the glioma stem cells (GSCs) population in glioblastoma multiforme (GBM). Isoform-level subtyping using The Cancer Genome Atlas revealed that both MNK genes (MKNK1 and MKNK2) are upregulated in mesenchymal GBM as compared to other subtypes. [Mol Cancer Res]
Investigators used the alkaline phosphatase assay to identify inhibitors for cancer stemness in induced cancer stem-like (iCSCL) cells. They screened several compounds from natural product chemical library and evaluated hit compounds for their efficacy on cancer stemness in iCSCL tumorspheres. [J Clin Pathol]
Researchers aimed to demonstrate that CD133 regulates hypoxia inducible factor (HIF)-1α expression with tumor migration. The CD133+ pancreatic cancer cell line, Capan1M9, was compared with the CD133– cell line, shCD133M9, under hypoxia. [Int J Mol Sci]
The authors discuss the current state-of-the-art and latest findings regarding the concept of cellular plasticity and heterogeneity in epithelial-mesenchymal transition (EMT). They raise some of the questions pending and identify the challenges faced in this fast-moving field. [Cell]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Heptares Therapeutics announced it has been notified by its partner AstraZeneca that the first subject has been dosed with immuno-oncology candidate HTL1071 (AZD4635) in a Phase I clinical study, triggering a US$10 million payment from AstraZeneca. [Heptares Therapeutics]
GenomeDx Biosciences announced that it has received Laboratory Accreditation from the College of American Pathologists (CAP) based on results of a recent on-site inspection as part of the CAP Laboratory Accreditation Program. [GenomeDx Biosciences]
Biocept, Inc. announced the granting of Japanese patent #5923035 for Devices and Methods of Cell Capture and Analysis. The patent covers the use of antibodies in the capture of rare cells, such as circulating tumor cells from blood, as well as other biological fluids. [GenomeDx Biosciences]
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Home Cancer Stem Cell News Volume 5.26 | Jul 6 2016