|Cancer Stem Cell News 5.30 August 3, 2016|
Using colorectal cancer (CC) cell lines, patient-derived xenograft tissues and patient tissues, scientists report that CC cancer stem cells (CSCs), which resist chemoradiation, have higher SUMO activating enzyme and global SUMOylation levels than non-CSCs. [Nat Commun]
Authors discovered that the bulk of the tumor-specific gene expression is controlled by an ectopic network of a few transcription factors that are overexpressed and/or hyperactivated in tumor cells. [Curr Biol]
Inhibitor of differentiation 1 (ID1) is highly expressed in glioblastoma stem cells (GSCs). However, the regulatory mechanism responsible for its role in GSCs is poorly understood. Investigators report that ID1 activates GSC proliferation, self-renewal, and tumorigenicity by suppressing CULLIN3 ubiquitin ligase. [Cell Rep]
Researchers report that melanoma-specific CD133+ cancer stem cells exhibit increased tumor-initiating potential, tumor-endothelial cell interaction and lung metastasis. [J Invest Dermatol]
Using an immunotherapy-based syngeneic model of melanoma dormancy and GFP-labelled dormant cell-derived cell lines, researchers determined that vaccination against melanoma prevented tumor growth but did not prevent tumor cell dissemination or eliminate all tumor cells. The persistent disseminated melanoma tumor cells were quiescent and asymptomatic for one year. [Sci Rep]
The role of krüppel-like factor 8 (KLF8) in liver cancer stem cells (LCSCs) is not known. The authors investigated the role of KLF8 in LCSCs to determine if KLF8 is a novel marker of these cells. [Mol Carcinog]
Researchers report that downregulation of ASPP2, a member of the ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein (ASPP) family, bestowed hepatocellular carcinoma cells with stem-like properties and resistance to chemotherapy, including the expansion of side population fractions, formation of hepatospheroids, expression of stem cell-associated genes, loss of chemosensitivity, and increased tumorigenicity in immunodeficient mice. [Tumour Biol]
The authors investigated the tumorigenic potential of umbilical cord blood-derived mesenchymal stem cells relative to MRC-5 and HeLa cells (negative and positive controls, respectively) both in vitro and in vivo. [Toxicol Res]
Scientists investigated the therapeutic effects of dietary flavonoids, including apigenin, quercetin, and naringenin, against cancer stem cell-like phenotypes of human glioblastoma cell lines U87MG and U373MG. [Phytother Res]
In the present review, the authors explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. [Tumour Biol]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
HedgePath Pharmaceuticals, Inc. announced positive interim data from its ongoing, open-label Phase II(b) clinical trial studying the effect of SUBA™-Itraconazole oral capsules in patients with Basal Cell Carcinoma Nevus Syndrome, also known as Gorlin Syndrome. [HedgePath Pharmaceuticals, Inc.]
FibroStatin announced the development of a breakthrough treatment to inhibit the epithelial-mesenchymal transition (EMT), a fundamental underlying pathology active in drug-resistant invasive cancer and organ fibrosis. EMT is regarded as a very important but difficult process to target therapeutically. [FibroStatin (PR Newswire Association LLC.)]
Amgen and Advaxis, Inc. announced a global agreement for the development and commercialization of Advaxis’ ADXS-NEO, a novel, preclinical investigational cancer immunotherapy treatment that is designed to activate a patient’s immune system to respond against the unique mutations, or neoepitopes, contained in and identified from each individual patient’s tumor. [Amgen]
By the end of 2016 at least two vaccines against Zika will have completed Phase I safety trials, marking the first significant clinical progress towards preventing transmission of the virus. [Nat Rev Drug Discov]
Worried at the prospect of losing access to EU funding and collaborations, scientific societies have fired off numerous letters asking the government to keep their country in the EU’s research system, and warning of damage already caused by Brexit. [Nature News]
Most people in the United States are more worried than enthusiastic about the prospect of scientific advances such as gene editing and brain-chip implants, a survey of thousands suggests. [Nature News]
The United Kingdom’s mammoth periodic audit of its research is set for a shake-up that could change the way universities hire academics – and might also encourage scientists to spend more time on public engagement. [Nature News]
Antibiotics researchers are set to receive hundreds of millions of dollars from a new funding stream — but not everyone thinks the cash is being directed to the right place. [Nature News]
A startup company has launched the first clinical trial in the United States to test the antiaging benefits of young blood in relatively healthy people. But there’s a big caveat: It’s a pay-to-participate trial, a type that has raised ethical concerns before, most recently in the stem cell field. [ScienceInsider]
Is 65 too old to stay at the helm of a major research center? That question is sowing division at the Pasteur Institute in Paris, Science has learned, and has plunged the 128-year-old institute, home to 1200 scientists and the place where HIV was first isolated, into a leadership crisis. [ScienceInsider]
Up to now, Joshua Gordon has split his career between working with patients with mental illness and mice designed to mimic that illness. But this fall, the neuroscientist and psychiatrist will take control of the $1.5 billion U.S. National Institute of Mental Health in Bethesda, Maryland. [ScienceInsider]
Russia’s scientific community is reeling from news that the government plans to fire about 10,000 researchers over the next three years. [ScienceInsider]
NEW Keystone Symposium: TGFβ in Immunity, Inflammation and Cancer
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