Cancer Stem Cell News Volume 5.32 | Aug 17 2016

TOP STORY

Lineage-Specific and Single-Cell Chromatin Accessibility Charts Human Hematopoiesis and Leukemia Evolution

Scientists identified regulators governing hematopoietic differentiation and further showed the lineage ontogeny of genetic elements linked to diverse human diseases. [Nat Genet] Abstract

(Ranked by impact factor of the journal)

G9a/RelB Regulates Self-Renewal and Function of Colon-Cancer-Initiating Cells by Silencing Let-7b and Activating the K-RAS/β-Catenin Pathway

A siRNA screen targeting known epigenetic genes revealed that G9a profoundly impaired the chemo-resistance, self-renewal and metastasis of cancer-initiating cells obtained from patients with colorectal cancer. [Nat Cell Biol] Abstract

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

Researchers showed that in glioma hypoxia and acidosis functionally cooperate in inducing HIF transcription factors and cancer stem-like cells maintenance. [Cancer Res] Abstract

RBM-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-Like Cells

The authors report enrichment of the long non-coding RNA RBM5-AS1/LUST during sphere formation of colon cancer initiating cells. [Cancer Res] Abstract

The Promotion of the Transformation of Quiescent Gastric Cancer Stem Cells by IL-17 and the Underlying Mechanisms

Investigators aimed to explore the biological functions of the inflammatory cytokine interleukin-17 (IL-17) in gastric cancer metastasis and the distinct IL-17-induced transformation of quiescent gastric cancer stem cells. [Oncogene] Full Article

Poly Lactic-Co-Glycolic Acid Controlled Delivery of Disulfiram to Target Liver Cancer Stem-Like Cells

The authors developed a poly lactic-co-glycolic acid-encapsulated (PLGA) disulfiram (DS) protecting DS from the degradation in the bloodstream. In combination with copper, DS-PLGA significantly inhibited the liver cancer stem cell population. [Nanomedicine] Full Article | Graphical Abstract

Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas

Scientists identified rare cell populations expressing stem cell markers but not pituitary hormones; they isolated and expanded in vitro these cells, obtaining fibroblast-free, stem-like cultures from 38 pituitary adenoma samples. [Mol Neurobiol] Abstract

Cell Surface Galectin-3 Defines a Subset of Chemoresistant Gastrointestinal Tumor-Initiating Cancer Cells with Heightened Stem Cell Characteristics

Scientists examined the ability of galectin-3 to characterize the cancer stem cell (CSC) phenotype, and to identify a clinically important gastrointestinal cancer CSC population. [Cell Death Dis] Full Article

CD164 Promotes Lung Tumor-Initiating Cells with Stem Cell Activity and Determines Tumor Growth and Drug Resistance via Akt/mTOR Signaling

Using tissue microarrays, investigators determined that CD164 expression is correlated with clinicopathological characteristics in human lung cancer. The CD164 overexpression in normal lung epithelial cells led to malignant transformation in vitro, tumorigenicity in xenografted mice, stem cell-like property, and drug resistance through ATP-binding cassette transporters. [Oncotarget] Full Article

CD44 and CD24 Coordinate the Reprogramming of Nasopharyngeal Carcinoma Cells towards a Cancer Stem Cell Phenotype through STAT3 Activation

Scientists found that nasopharyngeal carcinoma cells with high expression of CD44 and CD24 proteins presented with pronounced cancer stem cells properties. [Oncotarget] Full Article

Let-7b Inhibits the Malignant Behavior of Glioma Cells and Glioma Stem-Like Cells via Downregulation of E2F2

The authors revealed that the upregulation of Let-7b, a member of the Let-7 microRNA family, inhibited proliferation, migration, and invasion in glioma cell lines. [J Physiol Biochem] Abstract

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles

The authors discuss the specific applications of gene-editing technologies in human hematopoietic stem and progenitor cells, as informed by prior experience with gene addition strategies. [Hum Gene Ther] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Pitt Cancer Institute Awarded Major Federal Grants for Early Cancer Detection

The University of Pittsburgh Cancer Institute, partnered with UPMC CancerCenter, will receive or is sharing in $15.5 million over five years from the National Cancer Institute to accelerate research into the early detection of cancer. [University of Pittsburgh] Press Release

Juno Therapeutics Announces Multiple Myeloma Partnership with Memorial Sloan Kettering Cancer Center and Eureka Therapeutics for Developing CAR T Cell Immunotherapy against Multiple Novel Targets

Juno Therapeutics, Inc. announced that it has entered into an exclusive license agreement with Memorial Sloan Kettering Cancer Center and Eureka Therapeutics, Inc. for a novel, fully-human binding domain targeting B-cell maturation antigen, along with binding domains against two additional undisclosed multiple myeloma targets to be used for the potential development and commercialization of chimeric antigen receptor (CAR) cell therapies for patients with multiple myeloma. [Juno Therapeutics, Inc.] Press Release

EMA Adopts New Biologic, Biosimilar Pharmacovigilance Guidance

The European Medicines Agency (EMA) on Monday announced new recommendations for monitoring the safety of biologics and biosimilars. The guidance will take effect on 16 August 2016. [Regulatory Affairs Professionals Society] Editorial | Guideline

A Tale of Two Governments: The Politician Behind Argentina’s Science Growth

Lino Barañao, the only minister to stay in power after last year’s elections, lays out his plans. [Nature News] Editorial

Candidate Cancer Drug Suspected After Death of Three Patients at an Alternative Medicine Clinic

A new type of cancer drug developed at Johns Hopkins University in Baltimore, Maryland, but not yet tested in clinical trials may have triggered the deaths of three patients who were undergoing an alternative cancer treatment by a nonmedical practitioner in Germany. [ScienceInsider] Editorial

NEW AACR’s Colorectal Cancer: From Initiation to Outcomes
September 17-20, 2016
Tampa, United States

Visit our events page to see a complete list of events in the community.

NEW Full Professor – Molecular Mechanisms of Tumorigenesis (German Cancer Research Center)

Postdoctoral Position – Metastatic Breast Cancer (Purdue Center for Cancer Research)

Core Staff Scientist (Moffitt Cancer Center)

Principal Investigator – Clinical Geneticist in Pediatric Leukemia (Children´s Cancer Research Institute, St. Anna Kinderkrebsforschung)

Bioinformatician – Bioinformatics Data Analysis (Children´s Cancer Research Institute, St. Anna Kinderkrebsforschung)

Scientific Coordinator – Scientific Project Management (The Swiss Federal Institute of Technology in Zurich)

Senior Research Assistant – Differentiation and Survival of Leukemia Stem Cells (The University of Texas MD Anderson Cancer Center)

Tenure Track Faculty – Biological Sciences Scholars Program (University of Michigan)

Postdoctoral Fellow – Cancer Stem Cell Biology (Cleveland Clinic Lerner Research Institute)

Postdoctoral Fellow – Synthetic Cancer Biology (Beth Israel Deaconess Medical Center and Harvard Medical School)

Postdoctoral Fellow – Tumor Biology in Multiple Myeloma (Lerner Research Institute, Cleveland Clinic)

Institute Associate Scientist III – Target Biology (MD Anderson Cancer Center)

Postdoctoral Fellowship – Wnt Pathway in Sarcoma Pathogenesis (University of Miami Health System)

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