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Pulmonary Cell News| Cancer Stem Cell News 5.37 September 21, 2016 | |
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TOP STORYOct4/miR-1246 Signaling Axis Drives Wnt/β-Catenin Activation in Liver Cancer Stem Cells Researchers showed that human miRNA, miR-1246, promotes cancer stemness including self-renewal, drug resistance, tumorigenicity and metastasis by activation of Wnt/β-catenin pathway via suppressing the expression of AXIN2 and GSK3β, two key members of the β-catenin destruction complex. Clinically, high endogenous and circulating miR-1246 was identified in hepatocellular carcinoma clinical samples and correlated with a worse prognosis. [Hepatology] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2 The molecular link between PI3K activation and cancer stem cell (CSC) properties found in this study provides insights into therapeutic strategies for head and neck squamous cell cancer (HNSCC). Constitutive expression of SOX2 in HNSCC cells generates a CSC-like population that enables CSC studies. [J Natl Cancer Inst] Abstract | Press Release Researchers report that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells (CSC) through modulation of the integrin-linked kinase ILK. Depleting ILK blocked stiffness and hypoxia-dependent acquisition of CSC marker expression and behavior, whereas ectopic expression of ILK stimulated CSC development under softer or normoxic conditions. [Cancer Res] Abstract | Press Release The authors previously achieved a screening of glycosylation-related genes to characterize specific genes involved in cancer stem cell (CSC) maintenance. Three genes, CHI3L1, KLRC3 and PRUNE2, were found to be overexpressed in glioblastoma undifferentiated cells (related to CSC) compared to the differentiated ones. The comparison of their roles suggest that KLRC3 gene coding for NKG2E, a protein initially identified in NK cells, is more important than both two other genes in glioblastomas aggressiveness. [J Cell Mol Med] Full Article The authors evaluated the expression patterns and clinical significance of chemokine receptor type 4 (CXCR4) as a novel cancer stem cell marker in renal cell carcinoma. [J Cancer Res Clin Oncol] Abstract The goal of this study was to determine if depletion of glutathione and inhibition of thioredoxin reductase activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol-dependent oxidative stress. [Radiat Res] Abstract Cancer Stem Cell Marker Cd90 Inhibits Ovarian Cancer Formation via β3 Integrin The underexpression level of CD90 in ovarian cancer cells and the evidence supporting the cellular mechanism have not been investigated. The authors found that CD90 overexpression suppresses sphere-forming ability and ALDH activity and enhances cell apoptosis, indicating that CD90 may reduce cell growth by the properties of cancer stem cells (CSCs) and anoikis. Furthermore, CD90 reduces the expression of other CSC markers, including CD133 and CD24. [Int J Oncol] Abstract | Download Full Article Given that there are few breast cancer stem cells, performing transcriptome sequencing on them thus far has not been possible. With the emergence of single-cell sequencing technology, the authors have now undertaken such a study. They prepared single-cell suspensions, which were sorted using flow cytometry from breast tumor tissue and adjacent normal breast tissue from two HER2-positive patients. [Tumor Biol] Abstract Researchers investigated the effects of Fructus Viticis total flavonoids on the characteristics of lung cancer stem-like cells derived from human small cell lung cancer NCI-H446 cell line and its potential mechanism. [BMC Complement Altern Med] Full Article | |
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REVIEWSCancer Stem Cells in Squamous Cell Carcinoma This review compares the properties of cancer stem cells (CSCs) in squamous cell carcinoma (SCC) with normal stem cells in the skin, summarizes current advances and characteristics of CSCs, and considers the challenges for CSC-targeted treatment of SCC. [J Invest Dermatol] Abstract Cd44: More than a Mere Stem Cell Marker The authors address the question of how CD44 might promote cancer cell stemness by interacting with extracellular matrix components, growth factors and cytokines. [Int J Biochem Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSGolden Meditech and MD Anderson Team Up to Create Cellenkos, Inc. Golden Meditech Holdings Limited and The University of Texas at MD Anderson Cancer Center have announced the creation of Cellenkos, Inc., a start-up enterprise focused on umbilical cord blood derived T-regulatory cellular therapies. [Golden Meditech Holdings Limited] Press Release UCSF Researchers Awarded Breast Cancer Research Funding from Susan G. Komen Three UCSF researchers have been awarded $680,000 in grants from Susan G. Komen to support projects in breast cancer research. [UCSF] Press Release CivaTech Oncology Inc. has received a notice of award from the NIH NCI SBIR Fast Track program for the first Phase of an 80 patient, multi-center pancreatic cancer study with the new FDA cleared CivaSheet® device. [CivaTech Oncology Inc. (BusinessWire)] Press Release | |
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POLICY NEWSTitanic Clash over CRISPR Patents Turns Ugly Much of the focus is on the teams centred at Berkeley and the Broad Institute, whose ‘foundational’ patents cover a wide swathe of CRISPR–Cas9 applications. Although Berkeley’s team filed for a patent first, the Broad opted for an expedited review process, and its patents were granted earlier. [Nature News] Editorial Spain Joins Bandwagon for ‘Openness’ About Animal Research The Spanish scientific community has pledged to become more transparent about animal research. Ninety research centers, universities, scientific societies, and companies around Spain have adopted a set of standards, launched by the Confederation of Spanish Scientific Societies, on how research organizations should open up communication channels about their use of laboratory animals. [Science Insider] Editorial New Fellowship Aims to Increase Diversity in the Life Sciences A new program aims to launch the careers of life scientists from underrepresented groups by providing up to 8 years of support, covering both the postdoctoral training and junior faculty stages. The Howard Hughes Medical Institute’s Hanna H. Gray Fellows Program will award up to 15 recipients with $60,000 of salary support and $20,000 in flexible funds paid to their institutions for each of up to 4 years of postdoc training. [Science Insider] Editorial
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EVENTSNEW Cancer Immunotherapy NEW Frontiers in Cancer Science Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scientist – Cell Division (Cancer Research UK Manchester Institute) NEW Postdoctoral Position – Tumor Immunology (Memorial Sloan Kettering Cancer Center) Cancer Scientists – Clinical and Translational Breast Cancer Research (Hamad bin Khalifa University) Postdoctoral Fellow – Program Manager (German Cancer Research Center) Scientific Officer – Peer Review Office (Associazione Italiana per la Ricerca sul cancro) Postdoctoral Fellow – Laboratory Studies Brain Cancer Stem Cells (Houston Methodist) Associate Scientist – Epigenetics of Cancer (Celgene Corporation) Full Professor – Molecular Mechanisms of Tumorigenesis (German Cancer Research Center) Postdoctoral Position – Metastatic Breast Cancer (Purdue Center for Cancer Research) Core Staff Scientist (Moffitt Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cancer Stem Cell News Volume 5.37 | Sep 21 2016
