Cancer Stem Cell News 6.25 June 27, 2017 | |
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TOP STORYAML1-ETO Requires Enhanced C/D Box snoRNA/RNP Formation to Induce Self-Renewal and Leukemia Researchers identified C/D box snoRNAs and rRNA 2′-O-methylation as critical determinants of leukemic stem cell activity. [Nat Cell Biol] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Investigators report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSCs in colorectal cancer. [Cancer Res] Abstract Researchers found treatment of MLL-fusion leukemia cells with the BET bromodomain inhibitor I-BET151 resulted in selective growth inhibition, whereas treatment of leukemia cells harboring a different oncogenic driver did not result in selective growth inhibition. [Elife] Full Article KLF4 Is a Tumor Suppressor in Anaplastic Meningioma Stem-Like Cells and Human Meningiomas By manipulating KLF4 expression in anaplastic meningioma stem-like cells, investigators demonstrated that KLF4 acts as a tumor suppressor during malignant progression in meningioma, affecting apoptosis, proliferation, invasion, and cell cycle. [J Mol Cell Biol] Abstract Linc00152 was up-regulated in glioma tissues as well as in glioma stem cells (GSCs). Knockdown of linc00152 inhibited cell proliferation, migration and invasion, while promoted GSC apoptosis. [Mol Cancer] Full Article A naturally occurring compound phenethyl isothiocyanate (PEITC) has been shown to have promising anticancer activity by modulating intracellular ROS. Authors report a novel synthetic analog of PEITC with superior in vitro and in vivo antitumor effects. [Cell Death Dis] Full Article Inhibition of FAK Kinase Activity Preferentially Targets Cancer Stem Cells Scientists report that inhibition of FAK kinase activity by VS-4718 or VS-6063 preferentially targets CSCs, as demonstrated by a panel of orthogonal CSC assays in cell line models and surgically resected primary breast tumor specimens cultured ex vivo. [Oncotarget] Full Article The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells The authors investigated the glioblastoma (GBM) ability to interconvert between stem and non-stem states through the evaluation of the expression of specific stem cell markers as well as cell communication proteins. [Transl Oncol] Full Article TMPRSS4 Promotes Cancer Stem Cell Traits by Regulating CLDN1 in Hepatocellular Carcinoma (HCC) The authors revealed that CLDN1 contributed to CSC features of HCC, which was altered by TMPRSS4 expression via ERK1/2 signaling pathway, providing promising targets for novel specific therapies. [Biochem Biophys Res Commun] Abstract Sam68 Allows Selective Targeting of Human Cancer Stem Cells Targeting of human CSCs requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells. This study identified Sam68 as a regulator of human CSC vulnerability. [Cell Chem Biol] Abstract | |
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REVIEWSMitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells High levels of mitochondrial fission activity are associated with high proliferation and invasiveness in some cancer cells and with self-renewal and resistance to differentiation in some stem cells. These observations reveal new ways in which mitochondria regulate cell physiology, through their effects on metabolism and cell signaling. [Cell Metab] Full Article Angiogenesis and Cancer Stem Cells: New Perspectives on Therapy of Ovarian Cancer Therapies targeted at CSCs, such as those employing metformin and salinomycin seem promising. Anti-angiogenic therapy with bevacizumab was found to be effective in all phases of ovarian cancer treatment. [Eur J Med Chem] Abstract Long-Lived Epidermal Cancer-Initiating Cells An understanding of the underlying pathogenesis of squamous cell carcinoma (SCC), with the identification of its cell of origin, is critical for developing targeted strategies for effective SCC treatment. [Int J Mol Sci] Full Article Targeting the Wnt Pathway in Cancer: A Review of Novel Therapeutics The authors provide an overview of agents that have been developed to target the Wnt pathways and a summary of pre-clinical and clinical trials. [Target Oncol] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSBoston Biomedical intends to work with study investigators to complete a full evaluation of the BRIGHTER Trial results. Final data and analyses will be provided to regulatory authorities and will be presented and published for the oncology community. [Boston Biomedical, Inc.] Press Release Cell Medica Acquires WT1 Cancer Immunotherapy from Cell and Gene Therapy Catapult Cell Medica announced the acquisition of Catapult Therapy TCR Limited and the initiation of a collaboration to establish cell therapy manufacturing for Cell Medica at CGT Catapult’s GMP manufacturing facility in Stevenage, UK. [Cell Medica] Press Release | |
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POLICY NEWSVaccine Ruling from Europe’s Highest Court Isn’t as Crazy as Scientists Think The Court of Justice of the European Union in Luxembourg handed down a judgment in a compensation case involving a French man who claimed that a vaccination for hepatitis B caused his multiple sclerosis. The ruling specifies what type of evidence is allowed in EU member states in such cases, but it prompted a flurry of negative press coverage. [Nature News] Editorial Putin Tightens Control over Russian Academy of Sciences The Russian government has taken further steps to tighten its grip on the Russian Academy of Sciences (RAS) in Moscow. The State Duma—one of the two chambers of the Russian parliament—passed the first draft of a new law that would give president Vladimir Putin the final say in the elections for RAS’s presidency. [ScienceInsider] Editorial Scientists in Limbo as US Supreme Court Allows Modified Travel Ban The US Supreme Court has reinstated a limited version of President Donald Trump’s temporary order banning travellers from six Muslim-majority countries from entering the United States. The court will hear a legal challenge to the ban in October. The court’s decision casts doubt on the fate of students and scientists from these countries who hope to study or work in the United States. [Nature News] Editorial
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EVENTSNEW Cold Spring Harbor Stem Cell Biology Meeting NEW AACR-NCI-EORTC Molecular Targets & Cancer Therapeutics Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Stem Cell and Developmental Biology (University of Copenhagen) Research Scientist – Bioinformatics (University of Glasgow) Postdoctoral Position – Cancer Biology (UCLA) Postdoctoral Scholar – Cancer Research (UCLA G.O. Discovery Laboratory) Postdoctoral Fellow – Stem Cell Biology and Epigenetics (University of South Carolina) Postdoctoral Fellow – Cancer Biology (Case Western Reserve University) Postdoctoral Positions – Cancer Biology (University of Minnesota) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Postdoctoral Associate – Cancer Research/Oncology (University of Miami) Postdoctoral Fellows – Cancer Stem Cell Biology (Genome Institute of Singapore) Research Officers – Cancer Stem Cell Biology (Genome Institute of Singapore) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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