Cancer Stem Cell News Volume 6.28 | Jul 19 2017

TOP STORY

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

Investigators showed that a large subset of patient-derived glioblastoma stem cells express high levels of Achaete-scute homolog 1 (ASCL1), a proneural transcription factor involved in normal neurogenesis. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK

The authors showed that a cell-penetrating peptide based on CX43 inhibited c-Src and focal adhesion kinase (FAK) and upregulated phosphatase and tensin homolog in glioma stem cells derived from patients. [Stem Cell Reports] Full Article

BAG3 Promotes Stem Cell-Like Phenotype in Breast Cancer by Upregulation of CXCR4 via Interaction with its Transcript

Scientists reported that BAG3 was induced under specific floating culture conditions that enrich breast CSC-like cells in spheres. Ectopic BAG3 overexpression increased CD44⁺/CD24⁻ CSC subpopulations, first-generation and second-generation mammosphere formation, indicating that BAG3 promotes CSC self-renewal and maintenance in breast cancer. [Cell Death Dis] Full Article

Aptamer-Mediated Survivin RNAi Enables 5-Fluorouracil to Eliminate Colorectal Cancer Stem Cells

Researchers showed that EpCAM-aptamer-guided survivin RNAi effectively downregulated survivin both in colorectal cancer cells in vitro and in a mouse xenograft model for colorectal cancer. [Sci Rep] Full Article

Targeting PTPRZ Inhibits Stem Cell-Like Properties and Tumorigenicity in Glioblastoma Cells

The authors found that sphere-forming cells from the rat C6 and human U251 glioblastoma cell lines showed high expression levels of PTPRZ-B, the short receptor isoform of PTPRZ. Stable PTPRZ knockdown altered the expression levels of stem cell transcription factors such as SOX2, OLIG2, and POU3F2 and decreased the sphere-forming abilities of these cells. [Sci Rep] Full Article

A Balanced Level of Profilin-1 Promotes Stemness and Tumor-Initiating Potential of Breast Cancer Cells

Scientists demonstrated that profilin-1 (Pfn1) overexpression reduces the stem-like phenotype of MDA-MB-231 triple-negative breast cancer cells. The stem-like trait of MDA-231 cells is also attenuated upon depletion of Pfn1. [Cell Cycle] Abstract

The Pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells

AT101 effectively eliminated leukemia stem cells in vitro through the induction of DNA damage and activation of the intrinsic apoptotic pathway. [Target Oncol] Abstract

Ursodeoxycholic Acid Inhibits the Proliferation of Colon Cancer Cells by Regulating Oxidative Stress and Cancer Stem-Like Cell Growth

Investigators evaluated the effect of ursodeoxycholic acid upon the proliferation of colon cancer cells as a direct result of the regulation of reactive oxygen species. [PLoS One] Full Article

Hinokitiol Suppresses Cancer Stemness and Oncogenicity in Glioma Stem Cells by Nrf2 Regulation

Researchers investigated the therapeutic effect of hinokitiol, a natural bioactive compound of aromatic tropolone, on the characteristics of glioma stem cells and the possible mechanism. [Cancer Chemother Pharmacol] Abstract

A Novel Oncolytic Adenovirus Targeting Wnt Signaling Effectively Inhibits Cancer-Stem Like Cell Growth via Metastasis, Apoptosis and Autophagy in HCC Models

Recombinant adenovirus effectively induced the apoptosis, inhibit metastasis of hepatic CSC-like cells in vivo. Further animal experiments indicated that Ad-wnt-E1A(△24bp)-TSLC1 could effectively inhibit the growth of transplanted tumor of hepatic CSCs and prolong the survival time of mice. [Biochem Biophys Res Commun] Abstract

Potential Mechanisms of CD133 in Cancer Stem Cells

Researchers introduce and summarize the functions of CD133 in CSCs and suggest new mechanisms that may be of note in the approach to developing novel cancer therapies. [Life Sci] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Imago BioSciences Doses First Patients in the Phase IIa Portion of the Study of IMG-7289 in Acute Myeloid Leukemia and Myelodysplastic Syndrome

Imago BioSciences announced that the first patients have been dosed in a Phase I/II clinical trial of IMG-7289 for the treatment of high-risk acute myeloid leukemia and high-risk myelodysplastic syndrome. [Imago BioSciences] Press Release

FDA Grants Full Approval for BLINCYTO^® (Blinatumomab) to Treat Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia in Adults and Children

Amgen announced that the FDA has approved the supplemental Biologics License Application for BLINCYTO^® to include overall survival data from the Phase III TOWER study. [Amgen Inc.] Press Release

Some Scientists Hate NIH’s New Definition of a Clinical Trial. Here’s Why

Scientists in behavioral research fields — from cognitive psychology to vision science — were dismayed to learn that the U.S. National Institutes of Health (NIH) in Bethesda, Maryland, could soon deem their studies to be clinical trials. [ScienceInsider] Editorial

Salk Institute under Fire for ‘Smear’ on Women Suing It for Discrimination

Alleging decades of gender discrimination, two senior female scientists sued the Salk Institute for Biological Studies, sparking a public relations debacle that has engulfed the venerable institution and could threaten its appeal to donors and new researchers. Leaders of the San Diego, California, research center have strenuously denied the allegations made by biologists Vicki Lundblad and Katherine Jones, and publicly questioned their productivity and the quality of their scientific work. [ScienceInsider] Editorial

Relatively Few NIH Grantees Get Lion’s Share of Agency’s Funding

The rich have been getting richer in the biomedical research enterprise, and the system favors those who are already doing pretty well, according to a new analysis of National Institutes of Health (NIH) grant recipients. [ScienceInsider] Editorial

NEW 3^rd International Cancer Symposium
September 25-27, 2017
Lyon, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Fellow – Immunology (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Cell Signaling and Cancer Biology (Rutgers Cancer Institute of New Jersey)

Postdoctoral Fellowship – Epithelial Stem Cell Biology (University of Michigan Healthcare System)

Postdoctoral, PhD and Technician Positions – Cancer Metabolism (Université Catholique de Louvain)

Postdoctoral Position – Stem Cell and Developmental Biology (University of Copenhagen)

Research Scientist – Bioinformatics (University of Glasgow)

Postdoctoral Position – Cancer Biology (UCLA)

Postdoctoral Scholar – Cancer Research (UCLA G.O. Discovery Laboratory)

Postdoctoral Fellow – Stem Cell Biology and Epigenetics (University of South Carolina)

Postdoctoral Position – Gene Regulation in Stem Cells and Tissue Regeneration (Northwestern University)

Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University)

Postdoctoral Fellows – Cancer Stem Cell Biology (Genome Institute of Singapore)

Research Officers – Cancer Stem Cell Biology (Genome Institute of Singapore)

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