|Cancer Stem Cell News 7.14 April 11, 2018|
A subset of liver cells with high levels of telomerase renews the organ during normal cell turnover and after injury, according to researchers. The cells may also give rise to liver cancer. [Press release from Stanford Medicine discussing online prepublication in Nature]
Scientists provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. They used an innovative one-class logistic regression (OCLR) machine-learning algorithm to extract transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. [Cell]
Investigators interrogated reciprocal signaling between glioblastoma stem cells (GSCs) and their differentiated glioblastoma cell (DGC) progeny. They found that DGCs accelerated GSC tumor growth. [Cell Stem Cell]
Scientists describe a novel synthetic retinoid, namely WYC-209, which inhibits proliferation of malignant murine melanoma tumor-repopulating cells, known to resist conventional drug treatment, with an IC50 of 0.19-μM in a dose-dependent manner. [Nat Commun]
IFN-I receptor-/- neu+/- (IFNAR-neuT) tumors exhibited deregulation of genes having adverse prognostic value in breast cancer patients, including the breast cancer stem cell (BCSC) marker aldehyde dehydrogenase-1A1 (ALDH1A1). An increased number of BCSCs were observed in IFNAR-neuT tumors, as assessed by ALDH1A1 enzymatic activity, clonogenic assay, and tumorigenic capacity. [Cancer Immunol Res]
Researchers investigated whether gambogic acid inhibits the CSCs of colorectal cancer and its possible mechanisms. [Cell Physiol Biochem]
Lgr5-positive subpopulations exhibited higher capacities for colony formation, self-renewal, differentiation, and tumorigenicity as well as higher expression of stemness genes and mesenchymal genes and lower expression of epithelial genes than did Lgr5-negative subpopulations. [Cell Physiol Biochem]
The authors indicated that downregulating TBX21 in lung cancer cells decreased the fraction of cancer stem cells and their sphere and tumor initiation frequency. They showed that TBX21 activation transduced a TBX21-IL-4 signaling cascade to promote tumor initiation, tumor growth and expression of stemness markers. [Stem Cell Res Ther]
Researchers demonstrated that long-term exposure of human bronchial epithelial cells to tobacco smoke resulted in malignant transformation and acquisition of CSC-like properties. [Toxicol Lett]
To illustrate and study cancer cell plasticity in hematopoietic cancers, scientists employed an in vitro experimental model of ALK-positive anaplastic large-cell lymphoma that is based on the phenotypic and functional dichotomy of these cells, with cells responsive to a Sox2 reporter being significantly more stem-like than those unresponsive to the reporter. [BMC Cancer]
Scientists showed that quercetin (Que) significantly enhanced the antitumor activities of doxorubicin (Dox), paclitaxel (Pac), and vincristine (Vcr) in breast cancer cells. In addition, combined treatment of Dox, Pac, or Vcr with Que significantly downregulated P-glycoprotein (P-gp) expression and eliminated breast cancer stem cells. [Phytother Res]
Researchers investigated whether in vitro concentrations of DHA equal to human plasma levels, are able to modulate, Wt-p53, survivin, and microRNA-16-1 in colorectal cancer cells with stem cell-like properties. [Genes Nutr]
The authors summarize the current understanding of how Wnt signals are generated and interpreted. [Wiley Interdiscip Rev Syst Biol Med]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Christoph Rader, PhD, associate professor at the Florida campus of The Scripps Research Institute, has been awarded a $2.875 million, five-year grant from the National Cancer Institute to develop unique antibody-drug conjugates engineered to eradicate one of the most common forms of leukemia, chronic lymphocytic leukemia. [The Scripps Research Institute]
The University of Minnesota’s Clinical and Translational Science Institute received more than $42 million in renewed National Institutes of Health funding through the National Center for Advancing Translational Sciences’ Clinical and Translational Science Award program. [University of Minnesota]
Scientists at Edinburgh are to receive £2.4 million to find new ways to tackle brain tumors. The funding from leading charity Cancer Research UK will help researchers to understand more about how to target tumors with drugs. [The University of Edinburgh]
The Spanish government has announced plans to raise the country’s overall public R&D budget by 8.3% in 2018, from €6.5 billion to €7 billion—the biggest hike since the economic crisis hit Spain in 2008. [ScienceInsider]
The owner of the large scholarly search engine Web of Science — Clarivate Analytics — has bought a start-up company whose tool gives researchers one-click, legal access to journal articles even when off campus. [Nature News]
The Indian government has adopted its first regulations on academic plagiarism—rules that some researchers say are too lenient and others fear go too far and will be difficult to implement. [ScienceInsider]
A group of researchers has released the first results of a large survey of those who participated in and supported last year’s March for Science. Some social scientists say the analysis is fundamentally flawed and reflects poorly on an organization that champions scientific rigor. [ScienceInsider]
Many UK science employers pay women much less than men, and some institutions are far less equal than others, according to an analysis conducted by Nature of statistics released last week. [Nature News]
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