Cancer Stem Cell News Volume 7.20 | May 23 2018

TOP STORY

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Leukemia Cells to PARP1 Inhibitors

The combination of FMS-like tyrosine-kinase 3 (FLT3) inhibitors and PARP1 inhibitors eliminated FLT3(ITD)-positive quiescent and proliferating leukemia stem cells as well as leukemic progenitors from human and mouse leukemia samples. [Blood] Abstract

(Ranked by impact factor of the journal)

TGFβ Signaling Limits Lineage Plasticity in Prostate Cancer

Researchers showed that mouse prostate tumors lacking Pten and transforming growth factor (TGF) β type II receptor have higher expression of stem cell markers and genes indicative of basal epithelial cells, and that basal cell proliferation is increased compared to Pten mutants. [PLoS Genet] Full Article

Rapid Phenotyping of Cancer Stem Cells Using Multichannel Nanosensor Arrays

The authors report rapid discrimination of breast CSCs from non-CSCs using a nanoparticle-fluorescent-protein based sensor. This nanosensor was employed to discriminate CSCs from non-CSCs, as well CSCs that had differentiated in vitro in two breast cancer models. [Nanomedicine] Abstract | Graphical Abstract

Epigenetic Dysregulation of ZEB1 Is Involved in LMO2-Promoted T-Cell Acute Lymphoblastic Leukemia Leukemogenesis

Downregulation of ZEB1 by LIM only 2 (LMO2) complex resulted in an increased leukemia stem cell phenotype as well as unsensitivity in response to methotrexate chemotherapy in T-cell acute lymphoblastic leukemia cells. [Biochim Biophys Acta] Abstract

let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 Axis Coordinate to Maintain Cancer Stem Cell Population in Cervical Cancer

Scientists identified the coordination among miRNAs and EGF pathway genes which is critical for the maintenance of CSCs in cervical cancer. [Sci Rep] Full Article

Induction of Multiple Myeloma Cancer Stem Cell Apoptosis Using Conjugated Anti-ABCG2 Antibody with Epirubicin-Loaded Microbubbles

Treatment with anti-ABCG2 monoclonal antibody (EPI-MBs + mAb) with ultrasound exposure remarkably inhibited the growth of multiple myeloma CSC-derived tumors in xenograft nonobese diabetic/severe combined immunodeficient mice compared with a single agent or EPI-MBs + mAb without ultrasound exposure. [Stem Cell Res Ther] Full Article

A Small Molecule p53 Activator Attenuates Fanconi Anemia Leukemic Stem Cell Proliferation

Investigators showed that low levels of the p53 protein enhance the capacity of leukemic stem cells from Fanconi anemia patients to repopulate immunodeficient mice. [Stem Cell Res Ther] Full Article

Antitumor Effect of Axitinib Combined with Dopamine and PK-PD Modeling in the Treatment of Human Breast Cancer Xenograft

Axitinib up-regulated the expression of breast CSC (BCSC) markers in vivo, and dopamine significantly synergized the inhibitory effect on tumor growth by deducting the BCSC frequency. [Acta Pharmacol Sin] Abstract

LncTIC1 Interacts with β-Catenin to Drive Liver TIC Self-Renewal and Liver Tumorigenesis

LncTIC1 was highly expressed in liver tumor-initiating cells (TICs) and required for the self-renewal of liver TICs. LncTIC1 drove liver TIC self-renewal through Wnt/β-catenin signaling. [Clin Exp Med] Abstract

Synergistic Effect of TRAIL and Irradiation in Elimination of Glioblastoma Stem-Like Cells

The authors set up two GBM stem-like cells (GSLCs) cell lines from the two parental U87 and U251 glioma cell lines, and studied the expression of apoptosis-related genes alteration in GSLCs before and after irradiation. [Clin Exp Med] Abstract

The Natural Agent 4-Vinylphenol Targets Metastasis and Stemness Features in Breast Cancer Stem-Like Cells

Scientists enriched parental MDA-MB-231 cells with CSCs in serum-free medium to give spheroids. The effects of 4-vinylphenol on cancer stemness, metastasis and drug resistance in CSC-enriched MDA-MB-231 cells were studied in vitro and in vivo. [Cancer Chemother Pharmacol] Abstract

A Glial Blueprint for Gliomagenesis

Although the glioma stem cell sits at the apex of the cellular hierarchy, how it produces the vast cellular constituency associated with frank glioma remains poorly defined. The authors explore glioma tumorigenesis through the lens of glial development, starting with the neurogenic-gliogenic switch and progressing through oligodendrocyte and astrocyte differentiation. [Nat Rev Neurosci] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

IOTA Pharmaceuticals Announce the Creation of a Glioblastoma Drug Bank to Support and Accelerate New Research into Brain Cancer Therapy

IOTA Pharmaceuticals Ltd announced the creation of a new resource, the Glioblastoma Drug Bank, to accelerate drug discovery research in brain cancer, especially glioblastoma. [IOTA Pharmaceuticals Ltd (PR Newswire Association LLC.)] Press Release

WuXi Biologics and Bioasis Announce Initial Strategic Collaboration for the Development and Manufacturing of Bioasis’ Lead Investigational Candidate to Treat Brain Cancer

WuXi Biologics and Bioasis Technologies, Inc. announced an initial strategic collaboration for the development and manufacturing of xB³-001, Bioasis’ lead investigational biological candidate to treat brain cancer. [WuXi Biologics (PR Newswire Association LLC.)] Press Release

FDA Plans to Speed Path to Approval for Some Gene Therapies, Starting with Hemophilia

The FDA will soon be alerting companies that certain gene therapies in development can qualify for less arduous review at the agency. Gottlieb said that hemophilia is the first disease the FDA will target with its new policy. [STAT News] Editorial

Plans for £100M Nobel Centre Blocked by Swedish Court

A Swedish court has blocked the construction of a major new Nobel Centre in Stockholm intended as the future venue for the world’s most prestigious arts and science awards. [The Guardian] Editorial

PM Will Pay to Have ‘Full Association’ with EU Research

The Prime Minister made the strongest commitment yet to “fully associate” the UK with the EU’s £68bn research programme post-Brexit. Theresa May said the UK would be willing to make “an appropriate contribution” and in return it would expect a “suitable level of influence”. [BBC News] Editorial

Science Needs Clarity on Europe’s Data-Protection Law

As a commendable European law on personal data comes into force, the research community must not let excessive caution about data sharing, however understandable, become the default position. [Nature News] Editorial

NEW 20^th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy
September 13-16, 2018
Miami, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Research Assistant/Associate/Bioinformatician – Leukemic Stem Cells (University of Glasgow)

Postdoctoral Positions – High Mobility Group A Proteins in Cancer, Cancer Stem Cells, and Normal Development (Johns Hopkins University School of Medicine)

Postdoctoral Position – Stem Cell Bioinformatics (University of Copenhagen)

Postdoctoral Research Associate – Stem Cell and Cancer Biology (University of North Texas Health Science Center)

Postdoctoral Fellow – Glioma Epigenetics and Signaling (NYU School of Medicine)

Postdoctoral Position – Cancer Research (Institute for Research in Biomedicine)

Postdoctoral Research Fellow – Cancer Stem Cells (University of New South Wales)

Postdoctoral Associate – Cancer Research (St. Jude Children’s Research Hospital)

Professor – Cancer Stem Cell Research (Cardiff University)

Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham)

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