Cancer Stem Cell News Volume 7.21 | May 30 2018

TOP STORY

Ibrutinib Inactivates BMX-STAT3 in Glioma Stem Cells to Impair Malignant Growth and Radioresistance

Researchers demonstrated that bone marrow and X-linked (BMX) inhibition by ibrutinib potently disrupted glioma stem cells, suppressed glioblastoma malignant growth, and effectively combined with radiotherapy. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

Loss of MAOA in Epithelia Inhibits Adenocarcinoma Development, Cell Proliferation and Cancer Stem Cells in Prostate

Scientists investigated the role of monoamine oxidase A (MAOA) in the development of prostate adenocarcinoma by creating a prostate-specific Pten/MAOA knockout (KO) mouse model, in which MAOA-floxP mouse was crossed with the conditional Pten KO prostate cancer (PCa) mouse that develops invasive PCa. [Oncogene] Abstract

Mouse Intestinal Krt15⁺ Crypt Cells Are Radio-Resistant and Tumor Initiating

The authors demonstrated that Keratin 15 (Krt15) labels long-lived and multipotent cells in the small intestinal crypt by lineage tracing. Loss of the tumor suppressor Apc in Krt15⁺ cells lead to adenoma and adenocarcinoma formation. [Stem Cell Reports] Full Article

LncRNA MALAT1/miR-129 Axis Promotes Glioma Tumorigenesis by Targeting SOX4

Investigators explored the interaction among lncRNA MALAT1, miR-129 and SOX2. They investigated the effect of MALAT1 on the proliferation of glioma stem cells and glioma tumorigenesis. [J Cell Mol Med] Full Article

Restriction of γ34.5-Deleted Oncolytic Herpes Simplex Virus Replication in Glioblastoma Stem-Like Cells

Glioblastoma (GBM) stem-like cells (GSCs) and matched serum-cultured GBM cells (ScGCs), representative of bulk or differentiated tumor cells, were isolated from the same patient tumor specimens. ScGCs were permissive to γ34.5-deleted oncolytic herpes simplex virus replication and cell killing, while patient-matched GSCs were not, implying an underlying biological difference between stem and bulk cancer cells. [J Virol] Abstract

ATP-Binding Cassette Member B5 (ABCB5) Promotes Tumor Cell Invasiveness in Human Colorectal Cancer

In a prospective clinical study of 142 colorectal cancer (CRC) patients, researchers found that ABCB5 mRNA transcripts previously reported not to be significantly expressed in healthy peripheral blood mononuclear cells were significantly enriched in patient peripheral blood specimens compared with non-CRC controls and correlated with CRC disease progression. [J Biol Chem] Abstract | Full Article

Wnt11 Alters Integrin and Cadherin Expression by Ovarian Cancer Spheroids and Inhibits Tumorigenesis and Metastasis

Scientists investigated the role of Wnt11 in multicellular tumor spheroid-like structures ovarian cancer cell proliferation, migration and invasion in vitro and in vivo tumorigenesis and metastasis in xenograft nude mice model. [Exp Cell Res] Abstract

Combined Treatment with Sorafenib and Silibinin Synergistically Targets both HCC Cells and Cancer Stem Cells by Enhanced Inhibition of the Phosphorylation of STAT3/ERK/AKT

The authors found that the combination inhibited the formation and self-renewal of hepatocellular carcinoma (HCC) stem cells by down-regulating the expression of stemness-related proteins, such as homeobox protein NANOG and Krueppel-like factor 4. [Eur J Pharmacol] Abstract

miR-494 Inhibits Cancer-Initiating Cell Phenotypes and Reverses Resistance to Lapatinib by Downregulating FGFR2 in HER2-Positive Gastric Cancer

Scientists explored the effects of miR-494 and fibroblast growth factor receptor 2 (FGFR2) in regulation of cancer-initiating cell phenotypes and therapeutic efficiency of lapatinib in human epidermal growth factor receptor 2 (HER2)-positive gastric cancer. [Int J Mol Med] Abstract

Emerging Role of Exosome Signaling in Maintaining Cancer Stem Cell Dynamic Equilibrium

The authors summarize research on exosomes’ role in maintaining CSC dynamic interconversion state and the possible mechanism of action, which will provide a better understanding of the contribution of exosomes to dedifferentiation and stemness acquisition of non-CSCs. [J Cell Mol Med] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Schrödinger Announces Oncology Collaboration with Canada’s National Centre for Drug Research and Development to Develop Novel Biologics

Schrödinger, Inc. announced that it has established a collaboration with Canada’s national Centre for Drug Research and Development, to develop novel immuno-oncology monoclonal antibodies and other cancer biologics. [Schrödinger, Inc.] Press Release

U.S. FDA Grants Priority Review to Astellas’ New Drug Application for Gilteritinib for the Treatment of Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Astellas Pharma Inc. announced that the FDA has accepted, with Priority Review, the company’s New Drug Application for gilteritinib for the treatment of adult patients who have relapsed or refractory AML with a FLT3 mutation as detected by an FDA-approved test. [Astellas Pharma Inc.] Press Release

GlycoMimetics Announces NCI-Sponsored Pivotal Trial of GMI-1271 in Older, Newly Diagnosed AML Patients Fit for Intensive Chemotherapy

GlycoMimetics, Inc. announced it had signed a Cooperative Research and Development Agreement with the National Cancer Institute (NCI), part of the National Institutes of Health. [GlycoMimetics, Inc.] Press Release

Max Planck Scientists Criticize Handling of Animal-Rights Charges against Leading Neuroscientist

Scientists at one of Germany’s leading neuroscience institutes say that their employer, the Max Planck Society, is failing in its responsibility to defend the institute’s scientists against efforts by animal-rights activists to disrupt research. [Nature News] Editorial

Brexit: UK May Get Poorer Access than Israel to EU Science Scheme

Theresa May’s appeal for a special Brexit deal on science and research collaboration, worth billions to the British economy, is being stonewalled by Brussels as it prepares to offer an arrangement less privileged and more expensive than that given to non-EU states such as Israel. [The Guardian] Editorial

Will U.S. Academies Expel Sexual Harassers?

As high-profile sexual harassment cases fuel public criticism, the presidents of the U.S. National Academies of Sciences, Engineering, and Medicine announced they may adopt new policies allowing the prestigious bodies to eject members who have committed harassment and other forms of misconduct. [ScienceInsider] Editorial

NEW The New York Stem Cell Foundation (NYSCF) Conference
October 23-24, 2018
New York, New York, United States

Visit our events page to see a complete list of events in the community.

NEW PhD Student – Cell Signaling (German Cancer Research Center)

Research Assistant/Associate/Bioinformatician – Leukemic Stem Cells (University of Glasgow)

Postdoctoral Positions – High Mobility Group A Proteins in Cancer, Cancer Stem Cells, and Normal Development (Johns Hopkins University School of Medicine)

Postdoctoral Position – Stem Cell Bioinformatics (University of Copenhagen)

Postdoctoral Research Associate – Stem Cell and Cancer Biology (University of North Texas Health Science Center)

Postdoctoral Fellow – Glioma Epigenetics and Signaling (NYU School of Medicine)

Postdoctoral Position – Cancer Research (Institute for Research in Biomedicine)

Postdoctoral Research Fellow – Cancer Stem Cells (University of New South Wales)

Postdoctoral Associate – Cancer Research (St. Jude Children’s Research Hospital)

Professor – Cancer Stem Cell Research (Cardiff University)

Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham)

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