|Cancer Stem Cell News 7.23 June 13, 2018|
Scientists initiated LMO2 expression in hematopoietic stem/progenitor cells and maintained its expression in all hematopoietic cells. In order to uncover a potential exclusive reprogramming effect of LMO2 in murine hematopoietic stem/progenitor cells, they showed that transient LMO2 expression was sufficient for oncogenic function and induction of T-ALL. [EMBO J]
The authors demonstrated that hypoxia-inducible factor (HIF)-1-dependent regulation of mitogen-activated protein kinase signaling pathways contributes to chemotherapy-induced breast cancer stem cell enrichment. [Cancer Res]
Multicellular tumor spheroids exhibited greater resistance to chemotherapeutic agents, showed signs of senescence and hypoxia, and expressed a number of stem cell-associated transcripts including ALDH1A and CD133. [Cancer Res]
The role of Yes-associated protein 1 (YAP) and myocardin-related transcription factor A (MRTF-A), two transcriptional co-activators regulated downstream of G protein-coupled receptors and RhoA, in the growth of glioblastoma cells and in vivo glioblastoma multiforme tumor development was explored using human glioblastoma cell lines and tumor-initiating cells derived from patient-derived xenografts. [Oncogene]
Investigators defined the effects of the clinically relevant XPO1 inhibitor Selinexor on the radiosensitivity of glioblastoma cells. As determined by clonogenic survival analysis, selinexor enhanced the radiosensitivity of glioblastoma stem-like cells but not normal fibroblast cell lines. [Mol Cancer Ther]
Researchers showed that BMI-1 is highly expressed in glioblastoma multiforme and especially enriched in glioblastoma stem cells. [Cell Cycle]
Investigators showed that exogenous Ascl2 in colorectal cancer cells activated endogenous Ascl2 expression via a direct autoactivatory loop, including Ascl2 binding to its own promoter and further transcriptional activation. [Cell Cycle]
Researchers performed a series of functional experiments in vitro and orthotopic xenograft experiments in the mammary fat pad of nude mice. FLI-1, as a transcription factor, bound to the promoters of key epithelial-mesenchymal transition (EMT)-related genes, and regulated their expressions at the transcriptional level, thus induced EMT. [Cancer Med]
miR-18a-5p expression was downregulated in irradiated lung cancer cells. Overexpression of miR-18a-5p increased the radiosensitivity of lung cancer cells and inhibited the growth of A549 xenografts after radiation exposure. [Cancer Med]
The importance and benefits of the physical CSCs therapy methods such as nanomaterial-based heat treatments and particle therapy are highlighted. [Clin Transl Oncol]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Cellectar Biosciences, Inc. announced that the U.S. Patent and Trademark Office has granted patent application number 15/099,977 titled, “Ether and Alkyl Phospholipid Compounds for Treating Cancer and Imaging Detection of Cancer Stem Cells.” [Cellectar Biosciences, Inc.]
Arizona State University (ASU) has been awarded more than $8.5 million over five years from the National Cancer Institute to establish the Arizona Cancer and Evolution Center. The grant will establish ASU as the hub of an international network of research scientists who are dedicated to understanding cancer in an entirely new way. [Arizona State University]
Sexual harassment is pervasive throughout academic science in the United States, driving talented researchers out of the field and harming others’ careers, finds a report from the US National Academies of Sciences, Engineering, and Medicine in Washington DC. The analysis concludes that policies to fight the problem are ineffective because they are set up to protect institutions, not victims — and that universities, funding agencies, scientific societies and other organizations must take stronger action. [Nature News]
Florida State University (FSU) will head into negotiations with the publisher Elsevier to see how it can resolve a pricing issue. Back in April, FSU announced that it would not renew a so-called “big deal” with Elsevier in 2019, due to its “high and ever-increasing cost,” and would instead subscribe to a subset of the most-needed journals. [The Scientist]
China is getting tough on scientific misconduct. The country’s most powerful bodies, the Chinese Communist Party and the State Council, introduced a raft of reforms on 30 May aimed at improving integrity across the research spectrum, from funding and job applications to peer-review and publications. [Nature News]
Reversing yet another policy of the previous administration, the U.S. Department of State began applying tougher restrictions on some Chinese graduate students. The new policy shortens from five years to one year the duration of visas for those planning to study aviation, robotics, and advanced manufacturing. [ScienceInsider]
NEW Cancer Stem Cells: Impact on Treatment 2018
Visit our events page to see a complete list of events in the community.
Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!
Comments or suggestions? Submit your feedback here.