Cancer Stem Cell News 7.32 August 15, 2018 | |
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TOP STORYInvestigators have discovered that arsenic in combination with an existing leukemia drug work together to target a master cancer regulator. [Press release from Beth Israel Deaconess Medical Center discussing online prepublication in Nat Commun] Press Release | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers showed that the chemotherapeutic drug, paclitaxel, enhanced IRE1 RNase activity and this contributed to paclitaxel-mediated expansion of tumor-initiating cells. In a xenograft mouse model of triple-negative breast cancer, inhibition of IRE1 RNase activity increased paclitaxel-mediated tumor suppression and delayed tumor relapse post therapy. [Nat Commun] Full Article | Press Release Co-treatment with 5-fluorouracil (5-FU) and melatonin inhibited the stem cell markers Oct4, Nanog, Sox2, and ALDH1A1 by downregulating cellular prion protein. In this way, tumor growth, proliferation, and tumor-mediated angiogenesis were suppressed. In colorectal CSCs, PRNP overexpression protected Oct4 against inhibition by 5-FU and melatonin. [J Pineal Res] Abstract The multiple roles of miR-34a were maintained in a model of human breast cancer, in which chronic expression of miR-34a in triple-negative mesenchymal-like cells (enriched in CSCs) promoted a luminal-like differentiation program, restricted the CSC pool, and inhibited tumor propagation. [Oncogene] Full Article Reconstituting Glioma Perivascular Niches on a Chip for Insights Into Chemoresistance of Glioma Glioma stem cells and endothelial cells were specially co-cultured onto a biomimetric system to precisely control stem cell co-culture for proof-of-principle studies. The scientists demonstrated that the formation of perivascular niches effectively maintained the glioma stem cells at a pluripotent status owing to their successful cellular interactions. [Anal Chem] Abstract Application of chemotherapy treatment in acute myeloid leukemia-ETO9a leukemia mice led to the enrichment of a chemotherapy-resistant cell population identified as Lin– c-Kit+ c-MPL+. This c-MPL-positive cell population within Lin– c-Kit+ leukemia cells included a high percentage of cells in a quiescent state, enhanced colony formation ability and increased homing efficiency. [Stem Cells] Abstract SC-43 and SC-78 were more potent than regorafenib in suppressing the stemness properties of HCT-116 and HT-29 human colorectal cancer cells. SHP-1 knockdown almost completely abolished the suppressive effects of SC-43 and SC-78 on the sphere formation in both cell lines. [Cell Death Discov] Full Article The converse hsa-miR-324-5p/SOD2 relationship was associated with enhanced oncogenicity, which was effectively inhibited by 4-acetylantroquinonol B (4-AAQB), as evidenced by inhibited cell viability and proliferation, as well as attenuated migration, invasion, and clonogenicity in 4-AAQB-treated DLD1 and HCT116 cells. [Cancers] Full Article Anti-Thymocyte Globulin’s Activity against Acute Myeloid Leukemia Stem Cells At 10 mg/L rabbit anti-thymocyte globulin (ATG), blasts but not leukemic stem cells (LSCs) were killed. At 50 mg/L ATG, both blasts and LSCs were killed. The scientists also measured ATG-mediated killing of healthy individuals’ hematopoietic stem cells (HSCs). Median 2% HSCs from blood and 15% HSCs from filgrastim-mobilized grafts were killed with 50 mg/L ATG, compared to 30% LSCs from the blood of AML patients. [Bone Marrow Transplant] Abstract Researchers showed that the expression of stem cell-related genes and the hTERT gene in CNE-2R cells was higher than those in CNE-2 cells. The expression of stem cell-related proteins and the hTERT protein in CNE-2R cells was markedly higher than those in CNE-2 cells. Telomerase activity in CNE-2R cells was remarkably higher than that in CNE-2 cells. [Cancer Med] Full Article Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSTargeting Molecular Pathways in Cancer Stem Cells by Natural Bioactive Compounds The authors report and summarize in vitro and in vivo studies about the preventive, therapeutic and chemosensitizing effects of natural bioactive compounds on CSCs deriving from different types of tumors. [Pharmacol Res] Abstract | Graphical Abstract Hypoxia-Inducible Factor 2α: A Novel Target in Gliomas While HIF1α has been widely studied in cancer, HIF2α offers a potentially more specific and appealing target in glioblastoma given expression in glioma stem cells and not normal neural progenitors, activation in states of chronic hypoxia and expression that correlates with glioma patient survival. [Future Med Chem] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWS£3M Award for Pioneering Scottish Leukemia Trial Researchers at the University of Glasgow’s Institute of Cancer Sciences have been awarded £3.1 million by Cancer Research UK to lead a pioneering study to help find new treatments for chronic myeloid leukemia. [University of Glasgow] Press Release AIVITA Biomedical Announces Initiation of First Clinical Site for ROOT OF CANCER Glioblastoma Trial AIVITA Biomedical announced the initiation of its first clinical site for the Company’s ROOT OF CANCER Phase II trial in patients with newly diagnosed glioblastoma. The University of California, Irvine (UCI)’s Comprehensive Brain Tumor Program and the UCLA-UCI Alpha Stem Cell Clinic have received IRB approval to begin recruiting patients to receive AIVITA’s platform ROOT OF CANCER treatment. [Avita Medical (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSHow Unpaywall Is Transforming Open Science Unpaywall has become indispensable to many academics, and tie-ins with established scientific search engines could broaden its reach. On 26 July, Elsevier announced plans to integrate Unpaywall into its Scopus database searches, allowing it to deliver millions more free-to-read papers to users than it does currently. [Nature News] Editorial Iranian Students Protest US Visa Slowdown The rate at which the US government grants visas to prospective students from Iran has declined dramatically during President Donald Trump’s time in office, according to US government data. And the visas that are granted take more time to arrive, according to a group of Iranian students that is petitioning the Trump administration to speed up the process. [Nature News] Editorial Hundreds of Researchers from Harvard, Yale and Stanford Were Published in Fake Academic Journals In the so-called “post-truth era,” science seems like one of the last bastions of objective knowledge, but what if science itself were to succumb to fake news? Over the past year, German journalist Svea Eckert and a small team of journalists went undercover to investigate a massive underground network of fake science journals and conferences. [Vice Media LLC] Editorial
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EVENTSNEW 3rd Scientific Workshop on Tumor Microenvironment in the Hematological Malignancies and Its Therapeutic Targeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate/Senior Research Associate – Acute Myeloid Leukemia (University of Cambridge) PhD Student – Translational Bio-Medicine (German Cancer Research Center) Group Leader Positions – Precision Medicine (Italian Institute for Genomic Medicine) Postdoctoral Fellow – Cancer Research (The University of Texas MD Anderson Cancer Center) Postdoctoral Scholar – Statistical Bioinformatics (The University of Iowa) Tenure-Track Faculty Positions – Various (The Ohio State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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