Cancer Stem Cell News 7.43 October 30, 2018 | |
![]() | |
| |
TOP STORYThe SWI/SNF Complex Is a Mechanoregulated Inhibitor of YAP and TAZ Using a combination of gain- and loss-of-function approaches in several cellular contexts, the authors showed that YAP/TAZ are necessary to induce the effects of the inactivation of the SWI/SNF complex, such as cell proliferation, acquisition of stem cell-like traits and liver tumorigenesis. [Nature] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Scientists found that TRIB3 interacts with beta-catenin and TCF4 in intestine cells to increase expression of genes associated with CSCs. Knockdown of TRIB3 reduced colon neoplasia in mice, migration of colorectal cancer cells, and their growth as xenograft tumors in mice. [Gastroenterology] Abstract Collagen Prolyl 4-Hydroxylase 1 Is Essential for HIF-1α Stabilization and TNBC Chemoresistance Activation of the P4HA/HIF-1 axis enhanced cancer cell stemness, accompanied by decreased oxidative phosphorylation and reactive oxygen species levels. Inhibition of P4HA1 sensitized triple-negative breast cancer (TNBC) to the chemotherapeutic agent docetaxel and doxorubicin in xenografts and patient-derived models. [Nat Commun] Full Article miR-584-5p inhibited medulloblastoma growth and prolonged survival of mice in pre-clinical tumor models. miR-584-5p overexpression caused cell cycle arrest, DNA damage, and spindle defects in medulloblastoma cells. [Nat Commun] Full Article The silencing or inactivation of protein arginine methyltransferase 2 (PRMT2) inhibited glioblastoma multiforme cell growth and glioblastoma stem cell self-renewal in vitro, and suppressed orthotopic tumor growth, accompanied with significant deregulation of genes mainly associated with cell cycle progression and pathways in cancer. [Nat Commun] Full Article Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia Researchers showed that the integrated stress response (ISR) is uniquely active in hematopoietic stem cells (HSCs) and facilitates their persistence. Activating transcription factor 4 mediates the ISR and is highly expressed in HSCs due to scarcity of the eIF2 translation initiation complex. Primitive acute myeloid leukemia (AML) cells also displayed eIF2 scarcity and ISR activity marked leukemia stem cells in primary AML samples. [Cell Rep] Full Article | Graphical Abstract The Role of GLI-SOX2 Signaling Axis for Gemcitabine Resistance in Pancreatic Cancer Using acquired gemcitabine resistant pancreatic cell lines, scientists revealed an important role of the GLI-SOX2 signaling axis for regulation of gemcitabine sensitivity in vitro and in animal models. Down-regulation of GLI transcriptional factors, but not SMO signaling inhibition, reduces tumor sphere formation, a characteristics of tumor initiating cell. [Oncogene] Full Article The authors showed that osteopontin (OPN) is highly expressed and secreted in activated pancreatic stellate cells (PSCs) driven by hypoxia, and this process is in a ROS‐dependent manner; in addition, OPN was shown to be involved in the PSC‐induced epithelial‐mesenchymal transition and CSC‐like properties of pancreatic cancer cells. [Mol Oncol] Full Article | Press Release Treatment of spheroid-forming liver CSCs with oxytetracycline effectively decreased the spheroid formation and the CD133+ cell population. Oxytetracycline could suppress expression of CD133 without changing of expression of other stem cell-related markers. [Sci Rep] Full Article Lurbinectedin downregulated stem cell-related gene expression, inhibited HDAC1 activity, and effectively eliminated ALDH-high CSCs. [Invest New Drugs] Abstract Exogenous Cripto-1 Suppresses Self-Renewal of Cancer Stem Cell Model To investigate the biological effect of adding exogenous soluble CR-1 to the CSCs, scientists prepared a C-terminally truncated soluble form of recombinant human CR-1 protein, in which the glycophosphatidylinositol anchored moiety was removed by substitution of a stop codon through site-directed mutagenesis. [Int J Mol Sci] Full Article The Role of NF-κB and miRNA in Oral Cancer and Cancer Stem Cells with or without HPV16 Infection Selective over expression of miR-21 and miR-155 and downregulation of miR-34a were demonstrated by HPV+ve CSCs which overexpress HPV16 oncogene E6 that is responsible for the maintenance of stemness. [PLoS One] Full Article Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
| |
REVIEWSCancer from the Perspective of Stem Cells and Misappropriated Tissue Regeneration Mechanisms The authors address the issue of the identity of cancer-initiating cells and the presence of CSCs in growing tumors. They ask are there rare and distinct populations of CSCs in established tumor cell lines, or are all of the cells CSCs? [Leukemia] Full Article Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
| |
INDUSTRY NEWSRush Receives $5 Million Gift for Cancer Immunotherapy Research Rush University Medical Center has received a $5 million donation from Chicago philanthropists Robert and Emily King that will accelerate blood cancer immunotherapy research and the development of new treatment options. [Rush University Medical Center] Press Release Medicenna Provides Positive Interim Update from Phase IIb Trial of MDNA55 in Recurrent Glioblastoma Medicenna Therapeutics Corp. announced promising interim efficacy and safety results from patients treated at low doses in the on-going Phase IIb clinical trial of MDNA55 in recurrent glioblastoma. [Medicenna Therapeutics Corp.] Press Release AIVITA Biomedical Enrolls First Patient in Phase II Glioblastoma Trial AIVITA Biomedical, Inc. announced the enrollment of its first patient in the company’s Phase II clinical trial for newly diagnosed glioblastoma. [AIVITA Biomedical, Inc.] Press Release | |
| |
POLICY NEWSDo Authors Comply When Funders Enforce Open Access to Research? The first large-scale analysis of compliance with open-access rules reveals that up to one-third of articles are not free to read, report Vincent Larivière and Cassidy R. Sugimoto. [Nature News] Editorial Australia Plans ‘National-Interest’ Test for Research Grants Australia’s government is set to introduce a ‘national-interest test’ for research projects seeking grant funding from next year. The policy will require that researchers outline how their project will advance the country’s interests, said education minister Dan Tehan in a statement. [Nature News] Editorial Research Is Often Unpaid in Sub-Saharan Africa Unpaid research stints are the norm for scientists in sub-Saharan Africa, according to an online survey of 412 academics that spanned six countries. Eighty-five per cent of respondents report having had research positions with no pay. Of those, 33% had spent between one and five years doing research for free, and 4% had spent more than five years doing so. [Nature News] Editorial Hungarian Association Wins Prize for Promoting Participation of Women in Science Last April, Eszti Varga was one of 2,400 young women to converge on 120 universities and companies across Hungary as part of Girls’ Day, a campaign aimed at drawing high-school students into science and technology careers. Sponsored by the Association of Hungarian Women in Science, the campaign has attracted some 10,000 participants across the seven years that it has run. [Nature News] Editorial
| |
EVENTSNEW Developmental, Metabolic and (Epi)Genomic Mechanisms Driving Organogenesis and Tumorigenesis Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESFaculty Positions – Cancer & Stem Cell Biology (Duke-NUS Medical School) Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine) PhD Studentships – Cancer (The Cancer Research UK Manchester Institute) Computational Biologist/Bioinformatician – Hematopoiesis (Karolinska Institutet) Postdoctoral Associate – Hematopoiesis and Leukemia (The Jackson Laboratory) Postdoctoral Fellowship Positions – Translational Leukemia (Lund University) Faculty Positions – Cancer Biology (The Wilmot Cancer Institute) Postdoctoral Fellow – Leukemic Stem Cell Chemical Systems Medicine (University of Copenhagen) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|