Cancer Stem Cell News 8.03 January 30, 2019 | |
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TOP STORYFGL2 Promotes Tumor Progression in the CNS by Suppressing CD103+ Dendritic Cell Differentiation Scientists showed that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma cells. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The NUP98-HOXD13 Fusion Oncogene Induces Thymocyte Self-Renewal via Lmo2/Lyl1 Researchers found that thymocytes from preleukemic NHD13-Tg mice can serially transplant, demonstrating that they have self-renewal capacity. [Leukemia] Abstract CD44 Splice Isoform Switching Determines Breast Cancer Stem Cell State Investigators report that splice isoforms of the cancer stem cell marker CD44 exhibit strikingly opposite functions in breast cancer. [Genes Dev] Abstract | Press Release To investigate how cancer cells respond to activated but ineffective T cells, scientists challenged peptide-loaded MCF-7 breast cancer cells with antigen-specific CD8+ T cells in which lytic granules had been destroyed by pre-treatment with Concanamycin A. [Cancer Res] Abstract Investigators showed that cooperative interplay between the mitochondrial chaperone TRAP1 and the major mitochondria deacetylase sirtuin-3 in glioma stem cells increases mitochondrial respiratory capacity and reduces production of reactive oxygen species. [Cancer Res] Abstract Researchers found the lymphoid enhancer-binding factor-1, a transcriptional factor, was frequently overexpressed in hepatocellular carcinomas, which was significantly associated with poor prognosis and tumor cell differentiation. [Oncogene] Abstract TGFβ Promotes Breast Cancer Stem Cell Self-Renewal through an ILEI/LIFR Signaling Axis Investigators demonstrated that hnRNP E1 knockdown significantly shifts normal mammary epithelial cells to mesenchymal breast cancer stem cells in vitro and in vivo. [Oncogene] Abstract M2 macrophages form gap junctional intercellular communication with CSCs, resulting in cycling quiescence, reduced proliferation and carboplatin resistance. [Cell Death Dis] Full Article Histone Methyltransferase NSD2 Regulates Apoptosis and Chemosensitivity in Osteosarcoma Scientists showed that NSD2 knockdown leads to increased apoptosis in osteosarcoma (OS) cells in vitro and in vivo. Additionally, NSD2 knockdown significantly enhanced the efficacy of cisplatin against OS cells and accordingly inhibited properties associated with cancer stem cells. [Cell Death Dis] Full Article Combining lineage tracing in two tumor models with transcriptomic analyses, researchers found that Notch1+ tumor cells are undifferentiated, proliferative and capable of indefinite self-renewal and of generating a heterogeneous clonal progeny. [Sci Rep] Full Article The authors compared the stem cell niche in neonatal and adult bone marrow to investigate potential differences in their microenvironmental regulation of both normal and leukemic stem cells. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSUnderstanding the Cancer Stem Cell Phenotype: A Step Forward in the Therapeutic Management of Cancer The authors review the literature on the involvement of key signaling pathways such as Wnt/β-catenin, Notch, Hedgehog and STAT3 in the appearance of cancer cells with stem cells-like characteristics. In addition, they also highlight some of the recent therapeutic strategies used to target these pathways as well as approaches aiming to specifically target CSCs through their distinctive metabolic features. [Biochem Pharmacol] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSThe Janssen Pharmaceutical Companies of Johnson & Johnson announced the FDA approval of IMBRUVICA® in combination with obinutuzumab in treatment-naïve patients with chronic lymphocytic leukemia/small lymphocytic lymphoma, the most common form of leukemia in adults. [The Janssen Pharmaceutical Companies of Johnson & Johnson (PR Newswire Association, LLC.)] Press Release MacroGenics Announces Removal of Partial Clinical Hold on MGD009 Program by FDA MacroGenics, Inc. announced that the FDA has lifted the partial clinical hold on its Phase I monotherapy and combination studies of MGD009, a B7-H3 × CD3 bispecific DART® molecule. [MacroGenics, Inc.] Press Release | |
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POLICY NEWSUS Government Shutdown’s Effects on Science Ripple Overseas From canceled conferences to delayed publications, fallout of the shutdown spread beyond US borders, prompting concerns about long-term damage to international collaboration. [The Scientist] Editorial How Brexit Threatens Irish Science’s Cross-Border Collaboration Scientists in Northern Ireland and the Republic of Ireland are worried that Brexit will upset the island’s research ecosystem, which has benefited from peace and economic growth over the past 20 years. [Nature News] Editorial
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EVENTSNEW The NYSCF Conference 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Position – Ovarian Cancer Stem Cells (University of Minnesota) Postdoctoral Position – Stem Cell Aging and Cancer (University of California – San Francisco) Postdoctoral Fellow – Epigenetics and Cancer (The University of Texas MD Anderson Cancer Center) Postdoctoral Scientist – Leukemia Biology Group (Cancer Research UK Manchester Institute) Computational Biologist – Cancer Research (University of Miami) Postdoctoral Associate – Pediatrics, Cancer Biology (University of Massachusetts) Postdoctoral Position – Colon Cancer (Vanderbilt University) Postdoctoral Associate – Cancer Biology (University of Massachusetts) Postdoctoral Researcher – RNA Biology (Queen Mary University of London) Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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