Cancer Stem Cell News Volume 8.08 | Mar 6 2019

TOP STORY

Arrayed Molecular Barcoding Identifies TNFSF13 as a Positive Regulator of Acute Myeloid Leukemia-Initiating Cells

Researchers developed an ex vivo cytokine screen using 11 arrayed molecular barcodes, allowing for a competitive in vivo readout of leukemia-initiating capacity. With this approach, they assessed the effect of 114 murine cytokines on MLL-AF9 acute myeloid leukemia mouse cells and identified the tumor necrosis factor ligand superfamily member 13 (TNFSF13) as a positive regulator of leukemia-initiating cells. [Haematologica] Full Article

(Ranked by impact factor of the journal)

Deregulated GATA6 Modulates Stem Cell‐Like Properties and Metabolic Phenotype in Hepatocellular Carcinoma

Scientists investigated the role of GATA6, a transcription factor implicated in hepatocyte lineage specification, in hepatocellular carcinoma (HCC). They demonstrated a lower expression of GATA6 in HCC tissues compared with the corresponding non‐tumoral liver tissues. [Int J Cancer] Abstract

Cationic Lipoplexes for Treatment of Cancer Stem Cell-Derived Murine Lung Tumors

The authors outline the fabrication of a lipoplex of SOX2 small interfering RNA for targeted treatment of SOX2-enriched, CSC-derived orthotopic and xenograft lung tumors in CB-17 SCID mice. [Nanomedicine] Abstract | Graphical Abstract

Sustained NF-κB-STAT3 Signaling Promotes Resistance to SMAC Mimetics in Glioma Stem-Like Cells but Creates a Vulnerability to EZH2 Inhibition

Researchers evaluated the therapeutic efficacy of SMAC mimetics on glioma stem-like cells and showed that this family of compounds stimulated an adaptive response triggered by TNFα. [Cell Death Discov] Full Article

Fucosyltransferase 1 and 2 Play Pivotal Roles in Breast Cancer Cells

Scientists investigated the roles of FUT1 and FUT2 in breast cancer. Silencing of FUT1 or FUT2 by shRNAs inhibited cell proliferation in vitro and tumorigenicity in mice. [Cell Death Discov] Full Article

β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer

The role of β-arrestins (ARRBs) in regulating a stem cell-like phenotype and response to chemotherapy treatments was investigated. The consequence of forced expression of ARRBs on tumor growth and response to gemcitabine in vivo were investigated using bladder tumor xenografts in nude mice. [Mol Cancer Ther] Abstract

The Cancer Stem Cell Inhibitor Napabucasin (BBI608) Shows General Cytotoxicity in Biliary Tract Cancer Cells and Reduces Cancer Stem Cell Characteristics

Investigators tested the general cytotoxic effect of napabucasin on a comprehensive biliary tract cancer in vitro model, using resazurin assay and Annexin V/7-AAD staining. [Cancers] Full Article

Overexpression of Aiolos Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell-Like Properties in Lung Cancer Cells

Human lung cancer cell lines H1299 with overexpressing Aiolos and A549 with overexpressing Aiolos were generated by stable transfection. Cell migration and invasion assays were done to demonstrate their invasion and migration ability. [Sci Rep] Full Article

Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J

To address specific targeting of CSCs, researchers investigated the effects of a small molecule Verrucarin J on lung cancer cell lines A549 and H1793. [Stem Cell Rev] Abstract

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Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

Scientists summarize the current knowledge on glioblastoma stem-like cells (GSCs) with a particular focus on their metabolic complexity. They also discuss potential approaches targeting GSCs metabolism to potentially improve clinical care. [Front Oncol] Full Article

Targeting Cancer Stem Cells as Therapeutic Approach in the Treatment of Colorectal Cancer

The authors summarize the main findings of recent studies on targeting colorectal cancer stem cells as a novel therapeutic approach in colorectal cancer treatment. [Int J Biochem Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Bio-Path Announces Clinical Update to Interim Analysis of Phase II Prexigebersen Trial in Acute Myeloid Leukemia

Bio-Path Holdings, Inc. announced a clinical update to the previously reported interim analysis from the Phase II trial of prexigebersen for the treatment of acute myeloid leukemia and provides its plans for the compound’s clinical development moving forward toward registration. [Bio-Path Holdings, Inc.] Press Release

Oncotelic Reports Clinical Validation of Drug Induce Xenogenization (DIX) for Treatment of Glioblastoma and Pancreatic Cancer (PC)

Oncotelic announced clinical data supporting the use of chemotherapy-induced Xenogenization for the in situ immunization against glioblastoma and PC. [Oncotelic Inc. (GlobeNewswire, Inc.)] Press Release

DeGregorio Family Foundation Awards Grant to Sam Yoon of Memorial Sloan Kettering Cancer Center and Sandra Ryeom of University of Pennsylvania Perelman School of Medicine

Sam S. Yoon, MD, a surgical oncologist specializing in gastric and gastroesophageal junction cancers at Memorial Sloan Kettering Cancer Center, and Sandra Ryeom, Ph.D., Associate Professor of Cancer Biology at University of Pennsylvania Perelman School of Medicine have been awarded $100,000 by The DeGregorio Family Foundation for Gastric and Esophageal Cancer Research. [DeGregorio Family Foundation (PR Newswire Association, LLC)] Press Release

Head of US Food and Drug Agency Resigns

Scott Gottlieb, the head of the US Food and Drug Administration (FDA), resigned on 5 March and will depart the agency in one month. [Nature News] Editorial | Opinion

Trump Threatens to Cut Federal Research Funding Over Free Speech

At the Conservative Political Action Conference, President Donald Trump promised to sign an executive order cutting off funds to colleges and universities that do not maintain free speech. The president said “it will be very costly” if institutions don’t comply, but he did not give many details about the possible executive order or who would decide if schools were adequately protecting free speech. [The Scientist] Editorial

China Creating National Medical Ethics Committee to Oversee High-Risk Clinical Trials

A powerful new national medical ethics committee, which will approve all clinical trials involving high-risk biomedical technologies, is at the center of a regulatory shakeup Chinese authorities are planning in the aftermath of the widely condemned “CRISPR babies” experiment. [STAT News] Editorial

NEW 7^th International Stem Cell Meeting
November 12-13, 2019
Tel Aviv, Israel

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral & Research Associate Positions – Cancer, Cancer Stem Cells, Normal Development, and Aging (Johns Hopkins University)

Faculty Position – Prostate Cancer Biology and Cancer Epigenetics (Northwestern University Feinberg School of Medicine)

Postdoctoral Scholarship – Glioblastoma Stem Cell Research (Lund University)

Postdoctoral Positions – Stem Cell and Cancer Biology (Columbia University Irving Medical Center)

Tenure Track Faculty Position – Cancer Biology & Therapeutics (Geisel School of Medicine at Dartmouth)

Postdoctoral Position – Ovarian Cancer Stem Cells (University of Minnesota)

Postdoctoral Position – Stem Cell Aging and Cancer (University of California – San Francisco)

Postdoctoral Fellow – Epigenetics and Cancer (The University of Texas MD Anderson Cancer Center)

Postdoctoral Position – Stem Cells, Development and Cancer (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Associate – Pediatrics, Cancer Biology (University of Massachusetts)

Postdoctoral Position – Colon Cancer (Vanderbilt University)

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