|Cancer Stem Cell News 8.46 November 27, 2019|
Researchers reported that genetic or chemical inhibition of IGF2BP1 decreased leukemia cells’ tumorigenicity, promoted myeloid differentiation, increased leukemia cell death, and sensitized leukemia cells to chemotherapeutic drugs. [Leukemia]
Scientists showed that treatment naïve normal karyotype acute myeloid leukemia (AML), as well as samples AML leukemic stem cells, predominantly expressed the long β-catenin-binding isoform of LEF1 in sharp contrast to normal human hematopoietic stem cells. [Leukemia]
Investigators analyzed the possibility that thyroid hormone receptor β could affect a cancer stem cell population using MCF-7 cells grown under adherent conditions or as mammospheres, as well as inoculation into immunodeficient mice. [Thyroid]
ALM201 was a therapeutic peptide derived from FKBPL that had previously undergone preclinical and clinical development for oncology indications. ALM201 reduced cancer stem cells in cell lines and primary samples by inducing differentiation. [Br J Cancer]
Silencing of Long Noncoding RNA HOXA11-AS Inhibits the Wnt Signaling Pathway via the Upregulation of HOXA11 and Thereby Inhibits the Proliferation, Invasion, and Self-Renewal of Hepatocellular Carcinoma Stem Cells
The authors investigated the effects of homeobox A11 antisense on hepatocellular carcinoma stem cell characteristics. The expression patterns of HOXA11-AS and HOXA11 in hepatocellular carcinoma tissues, cells, and stem cells were determined. [Exp Mol Med]
Scientists investigated the combined use of CD271 and CD44 to isolate an enriched subpopulation of cancer stem cells, followed by their characterization in vitro, in vivo, and in patients’ tissue samples. [Carcinogenesis]
MUC1 induced cancer stem cell enrichment in paclitaxel-resistant cells via activation of epidermal growth factor receptor (EGFR), which directly enhanced IL-6 transcription through cAMP response element-binding protein (CREB) and glucocorticoid receptor β (GRβ). [Oncogenesis]
Researchers screened a small-molecule epigenetic inhibitor library using 3D in vitro models in order to determine potential epigenetic targets associated with self-renewal and tumorigenicity in canine mammary cancer cells. [Sci Rep]
Investigating the role of fibroblast growth factor (FGF) 2 in self-renewal in advanced colorectal cancer patient-derived organoids unveiled that FGF-receptor inhibition prevented organoid formation in very early expanding cells but induced cyst formation when applied to pre-established organoids. [Sci Rep]
Scientists present the progress to date of miRNA research associated with stemness marker expression, signaling pathways and activation of transcription networks to regulate the self-renewal, differentiation and therapy resistance properties of breast cancer stem cells. [Mol Diagn Ther]
Researchers provide an overview of the mechanisms underlying the mutual interaction between cancer stem cells/cancer initiating cells and tumor microenvironment. Particular focus is dedicated to the immunological profile of cancer stem cells/cancer initiating cells and their role in orchestrating cancer immunosurveillance. [Cancer Microenviron]
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AstraZeneca announced that the FDA has approved Calquence for adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. The US approval was granted under the FDA’s Real-Time Oncology Review and newly established Project Orbis programs. [AstraZeneca]
FORMA Therapeutics, Inc. announced positive Phase Ib/II results from an ongoing study in patients with IDH1-mutated gliomas. The data demonstrated blood-brain barrier penetrance, as exhibited by cerebrospinal fluid exposure, and disease response to olutasidenib, a next-generation IDH1m inhibitor. [FORMA Therapeutics, Inc.]
A swift increase in scientific productivity has outstripped China’s ability to promote rigor and curb academic misconduct; it is time to seize solutions. [Nature News]
Publishing giant Elsevier has signed its first open-access deal with a US institution, Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. The arrangement will allow CMU scholars to publish articles in any Elsevier journal on an immediately free-to-read basis. [ScienceInsider]
NEW 6th American Association for Cancer Research (AACR) International Association for the Study of the Lung (IASLC) International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic
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