Cancer Stem Cell News Volume 8.46 | Nov 27 2019

TOP STORY

RNA-Binding Protein IGF2BP1 Maintains Leukemia Stem Cell Properties by Regulating HOXB4, MYB, and ALDH1A1

Researchers reported that genetic or chemical inhibition of IGF2BP1 decreased leukemia cells’ tumorigenicity, promoted myeloid differentiation, increased leukemia cell death, and sensitized leukemia cells to chemotherapeutic drugs. [Leukemia] Abstract

(Ranked by impact factor of the journal)

Differences in Expression and Function of LEF1 Isoforms in Normal versus Leukemic Hematopoiesis

Scientists showed that treatment naïve normal karyotype acute myeloid leukemia (AML), as well as samples AML leukemic stem cells, predominantly expressed the long β-catenin-binding isoform of LEF1 in sharp contrast to normal human hematopoietic stem cells. [Leukemia] Abstract

The Thyroid Hormone Receptor β Inhibits Self-Renewal Capacity of Breast Cancer Stem Cells

Investigators analyzed the possibility that thyroid hormone receptor β could affect a cancer stem cell population using MCF-7 cells grown under adherent conditions or as mammospheres, as well as inoculation into immunodeficient mice. [Thyroid] Abstract

FKBPL-Based Peptide, ALM201, Targets Angiogenesis and Cancer Stem Cells in Ovarian Cancer

ALM201 was a therapeutic peptide derived from FKBPL that had previously undergone preclinical and clinical development for oncology indications. ALM201 reduced cancer stem cells in cell lines and primary samples by inducing differentiation. [Br J Cancer] Abstract

Silencing of Long Noncoding RNA HOXA11-AS Inhibits the Wnt Signaling Pathway via the Upregulation of HOXA11 and Thereby Inhibits the Proliferation, Invasion, and Self-Renewal of Hepatocellular Carcinoma Stem Cells

The authors investigated the effects of homeobox A11 antisense on hepatocellular carcinoma stem cell characteristics. The expression patterns of HOXA11-AS and HOXA11 in hepatocellular carcinoma tissues, cells, and stem cells were determined. [Exp Mol Med] Abstract

Cancer Stem Cells Enrichment with Surface Markers CD271 and CD44 in Human Head and Neck Squamous Cell Carcinomas

Scientists investigated the combined use of CD271 and CD44 to isolate an enriched subpopulation of cancer stem cells, followed by their characterization in vitro, in vivo, and in patients’ tissue samples. [Carcinogenesis] Abstract

Erlotinib Overcomes Paclitaxel-Resistant Cancer Stem Cells by Blocking the EGFR-CREB/GRβ-IL-6 Axis in MUC1-Positive Cervical Cancer

MUC1 induced cancer stem cell enrichment in paclitaxel-resistant cells via activation of epidermal growth factor receptor (EGFR), which directly enhanced IL-6 transcription through cAMP response element-binding protein (CREB) and glucocorticoid receptor β (GRβ). [Oncogenesis] Abstract

An Epigenetic Screening Determines BET Proteins as Targets to Suppress Self-Renewal and Tumorigenicity in Canine Mammary Cancer Cells

Researchers screened a small-molecule epigenetic inhibitor library using 3D in vitro models in order to determine potential epigenetic targets associated with self-renewal and tumorigenicity in canine mammary cancer cells. [Sci Rep] Full Article

FGF Signaling in the Self-Renewal of Colon Cancer Organoids

Investigating the role of fibroblast growth factor (FGF) 2 in self-renewal in advanced colorectal cancer patient-derived organoids unveiled that FGF-receptor inhibition prevented organoid formation in very early expanding cells but induced cyst formation when applied to pre-established organoids. [Sci Rep] Full Article

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MicroRNAs, a Promising Target for Breast Cancer Stem Cells

Scientists present the progress to date of miRNA research associated with stemness marker expression, signaling pathways and activation of transcription networks to regulate the self-renewal, differentiation and therapy resistance properties of breast cancer stem cells. [Mol Diagn Ther] Abstract

The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of These Cells with Immunotherapy

Researchers provide an overview of the mechanisms underlying the mutual interaction between cancer stem cells/cancer initiating cells and tumor microenvironment. Particular focus is dedicated to the immunological profile of cancer stem cells/cancer initiating cells and their role in orchestrating cancer immunosurveillance. [Cancer Microenviron] Full Article

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Calquence Approved in the US for Adult Patients with Chronic Lymphocytic Leukemia

AstraZeneca announced that the FDA has approved Calquence for adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. The US approval was granted under the FDA’s Real-Time Oncology Review and newly established Project Orbis programs. [AstraZeneca] Press Release

FORMA Therapeutics’ Olutasidenib Demonstrates Positive Phase Ib/II Results, Including Blood-Brain Barrier Penetration and Stable Disease in Patients with IDH1-Mutated Glioma

FORMA Therapeutics, Inc. announced positive Phase Ib/II results from an ongoing study in patients with IDH1-mutated gliomas. The data demonstrated blood-brain barrier penetrance, as exhibited by cerebrospinal fluid exposure, and disease response to olutasidenib, a next-generation IDH1m inhibitor. [FORMA Therapeutics, Inc.] Press Release

Five Ways China Must Cultivate Research Integrity

A swift increase in scientific productivity has outstripped China’s ability to promote rigor and curb academic misconduct; it is time to seize solutions. [Nature News] Editorial

Elsevier Signs First Open-Access Deal in the United States

Publishing giant Elsevier has signed its first open-access deal with a US institution, Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. The arrangement will allow CMU scholars to publish articles in any Elsevier journal on an immediately free-to-read basis. [ScienceInsider] Editorial

NEW 6^th American Association for Cancer Research (AACR) International Association for the Study of the Lung (IASLC) International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic
January 11-14, 2020
San Diego, California, United States

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NEW Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope)

Postdoctoral Position – Molecular Biology or Cancer (University of Liège)

Postdoctoral Fellow – Leukemia (University Hospital of Muenster)

Postdoctoral Position – Immune-Targeting of Leukemic Stem Cells (Karolinska Institutet)

Postdoctoral Studentship – HOX Interactors for Leukemia (University of Manchester)

Faculty Positions – Molecular and Cellular Biology (Baylor College of Medicine)

Postdoctoral Scholar – Cancer Biology (University of Kentucky)

Postdoctoral Position – Cellular Immunotherapy for Cancer (Tactiva Therapeutics)

Postdoctoral Position – Cancer Biology (Weill Cornell Medicine)

Assistant, Associate, or Professor – Hematology (Stanford University)

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