Cancer Stem Cell News Volume 9.00 | Jan 08 2020

TOP STORY

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intratumoral Heterogeneity

Investigators report methods for generating and biobanking patient-derived glioblastoma organoids that recapitulate the histological features, cellular diversity, gene expression, and mutational profiles of their corresponding parental tumors. [Cell] Abstract | Graphical Abstract | Press Release

(Ranked by impact factor of the journal)

Outer Radial Glia-Like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma

Scientists found that multiple glia-like cancer stem cells (GSCs) subtypes existed within a single tumor. Within these GSCs, they identified an invasive cell population similar to outer radial glia, a fetal cell type that expanded the stem cell niche in normal human cortex. [Cell Stem Cell] Abstract | Graphical Abstract

The MyoD Family Inhibitor Domain-Containing Protein Enhances the Chemoresistance of Cancer Stem Cells in the Epithelial State by Increasing β-Catenin Activity

Researchers found that epithelial-type (E-cadherin^high/CD133^high) cancer stem cells displayed a higher sphere formation ability and chemoresistance than mesenchymal-type (E-cadherin^lowCD133^high) cancer stem cells. [Oncogene] Abstract

UBE2O Promotes the Proliferation, EMT and Stemness Properties of Breast Cancer Cells through the UBE2O/AMPKα2/mTORC1-MYC Positive Feedback Loop

In vitro assays revealed that ubiquitin-conjugating enzyme E2O (UBE2O) promoted breast cancer cell proliferation and epithelial-mesenchymal transformation and endowed breast cancer cells with cancer stemness properties. [Cell Death Dis] Full Article

Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells

The authors investigated the ability of the cancer stem cells to differentiate into hematopoietic cells. Primary cells were isolated from malignant tumors that were formed by the cancer stem cells. [Cancers] Full Article | Graphical Abstract

Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells

Selected compounds were validated in both in vitro organoids and ex vivo colon explant models for their differentiation induction, impediment on neoplastic cell growth, and to elucidate the mechanism of their anticancer activity. [Cancers] Full Article | Graphical Abstract

Verteporfin Inhibits Oxidative Phosphorylation and Induces Cell Death Specifically in Glioma Stem Cells

Scientists demonstrated that glioma stem cells had high oxidative phosphorylation activity compared with isogenic differentiated-glioma stem cells and that glioma stem cell survival depended on their oxidative phosphorylation activity. [FEBS J] Abstract

Quinacrine and Curcumin Synergistically Increased the Breast Cancer Stem Cells Death by Inhibiting ABCG2 and Modulating DNA Damage Repair Pathway

Researchers evaluated the anti-proliferative activity of curcumin and quinacrine against cancer stem cells using an in vitro model system. Curcumin and quinacrine synergistically inhibited the proliferation, migration and invasion of cancer stem cells. [Int J Biochem Cell Biol] Abstract | Graphical Abstract

PTK7 Promotes the Malignant Properties of Cancer Stem-Like Cells in Esophageal Squamous Cell Lines

Cancer stem-like cells treated with PTK7 siRNA or a P53-specific inhibitor were analyzed for their sphere formation capacity and their apoptosis and migration/invasion capabilities by sphere formation, flow cytometry, and transwell assay, respectively. [Hum Cell] Abstract

Off-Target Effect of the BMI1 Inhibitor PTC596 Drives Epithelial-esenchymal Transition in Glioblastoma Multiforme

Scientists report that when used at appropriate concentrations, pharmaceutical inhibitors of BMI1 could efficiently prevent glioblastoma multiforme colony growth and cancer stem cell self-renewal in vitro and significantly extend lifespan in terminally ill tumor-bearing mice. [npj Precis Oncol] Abstract

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The Leukemia Stem Cell: Similarities, Differences and Clinical Prospects in CML and AML

Investigators review many of the similarities and differences that exist between leukemia stem cells in chronic myeloid leukemia (CML) and acute (Archive)ML and examine the therapeutic strategies that could be used to eradicate them. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Trillium Therapeutics Provides Update on Its TTI-621 and TTI-622 CD47 Programs

Trillium Therapeutics, Inc. provided an update on its TTI-621 and TTI-622 clinical programs. “We have now completed the initial dose finding and signal seeking parts of our Phase I study of intravenous TTI-621 at doses up to 0.5 mg/kg,” said Dr. Jan Skvarka, President and Chief Executive Officer of Trillium. [Trillium Therapeutics, Inc.] Press Release

GlycoMimetics and Apollomics Announce Exclusive Collaboration and License Agreement to Develop and Commercialize Uproleselan and GMI-1687 in Greater China

GlycoMimetics, Inc. and Apollomics, Inc. announced an exclusive collaboration and license agreement for the development and commercialization of uproleselan and GMI-1687 in Mainland China, Hong Kong, Macau and Taiwan, also known as Greater China. [GlycoMimetics, Inc.] Press Release

From Service to Science: NIH Shifts Focus of Mentoring Network Aimed at Boosting Grantee Diversity

As co-director of graduate affairs at the University of Chicago, Nancy Schwartz spent the past four years helping faculty members at 15 major research universities become better mentors. The project was supported by the National Research Mentoring Network, a $23 million effort that the National Institutes of Health launched after discovering an embarrassing racial gap in who gets NIH grants. [ScienceInsider] Editorial

UK Group Tackles Reproducibility in Research

Last month, ten UK universities became part of the UK Reproducibility Network, joining a network that already includes stakeholders such as the Academy of Medical Sciences, Research Libraries UK, the National Institute for Biological Standards and Control, journals including Nature and PLOS, and local networks of researchers. [The Scientist] Editorial

NEW Canadian Liver Meeting 2020
February 28-March 1, 2020
Montreal, Quebec, Canada

Visit our events page to see a complete list of events in the community.

NEW Team Leader – Clonal Evolution in Leukemia (Institute of Cancer Research)

NEW Research Fellow – Glioblastoma Cell Signaling (University of Sussex)

NEW Postdoctoral Associate – Leukemia and Brain Tumors (Ann and Robert H. Lurie Children’s Hospital of Chicago)

NEW Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai)

Postdoctoral Scholarship – Brain Tumor Stemness (Lund University)

Research Associate – Cell Communication in Tumor Microenvironments (The University of Cambridge)

Postdoctoral Research Scholar – Cancer Biology and Stem Cells (Washington University School of Medicine)

Postdoctoral Research Fellow (German Cancer Research Center)

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope)

Postdoctoral Position – Molecular Biology of Cancer (University of Liège)

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