Cancer Stem Cell News Volume 9.03 | Jan 29 2020

TOP STORY

HSP90A Inhibition Promotes Anti-Tumor Immunity by Reversing Multi-Modal Resistance and Stem-Like Property of Immune-Refractory Tumors

Scientists demonstrated that HSP90A potentiated AKT activation through TCL1A-stabilization, thereby contributing to the multi-aggressive properties in NANOG^high tumor cells. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Low-Frequency TP53 Hotspot Mutation Contributes to Chemoresistance through Clonal Expansion in Acute Myeloid Leukemia

TP53 mutations (TP53mut) clones isolated from the parental cells showed increased chemoresistance potential and had higher population of leukemia stem cell maker positive cells, a characteristic of chemoresistant cells. [Leukemia] Abstract

Loss of Kat2a Enhances Transcriptional Noise and Depletes Acute Myeloid Leukemia Stem-Like Cells

Researchers demonstrated that Kat2a contributed to leukemia propagation through preservation of leukemia stem-like cells. Kat2a loss impacted transcription factor binding and reduced transcriptional burst frequency in a subset of gene promoters, generating enhanced variability of transcript levels. [eLife] Full Article

Cytokeratin 5 Alters β-Catenin Dynamics in Breast Cancer Cells

Investigators established through cytokeratin 5 (CK5) knockout and overexpression in estrogen receptor (ER)⁺ breast cancer cell lines that CK5 was important for tumorsphere formation, prompting them to speculate that CK5 had regulatory activity in cancer stem cells. [Oncogene] Abstract

Polycomb-Mediated Repression of EphrinA5 Promotes Growth and Invasion of Glioblastoma

Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells in a mouse model uncovered a novel epigenetic regulation of EfnA5. EfnA5 mediated Bmi1-dependent proliferation and invasion in vitro and tumor formation in an allograft model. [Oncogene] Full Article

p53 Functional States Are Associated with Distinct Aldehyde Dehydrogenase Transcriptomic Signatures

Aldehyde dehydrogenase isoform expression diversity was revealed in cancer initiating cells with disparate p53 functional states: gain of function, high risk p53 mutation and wildtype p53 inactivated by the human papillomavirus 16 E6 oncogene. [Sci Rep] Full Article

Cancer Cell’s Neuroendocrine Feature Can Be Acquired through Cell-Cell Fusion during Cancer-Neural Stem Cell Interaction

Scientists assessed the consequences of prostate cancer cell interaction with neural cells, which were rich in the human prostate and resident of the prostate tumor. In three-dimensional co-culture with neurospheres, red fluorescent human LNCaP cells formed agglomerates on the neurosphere surface. [Sci Rep] Full Article

AR-Induced ZEB1-AS1 Represents Poor Prognosis in Cholangiocarcinoma and Facilitates Tumor Stemness, Proliferation and Invasion through Mediating miR-133b/HOXB8

Knocking down zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) attenuated tumor cell stemness, restrained cellular viability in vitro and in vivo, and inhibited cholangiocarcinoma cell migration and invasion by reversing epithelial-mesenchymal transition. [Aging (Albany NY)] Full Article

G Protein-Coupled Receptor GPR87 Promotes the Expansion of Pancreatic Ductal Adenocarcinoma Stem Cells through Activating JAK2/STAT3

Scientists studied the role and regulatory mechanism of a G protein-coupled receptor named as G Protein-Coupled Receptor 87 (GPR87) in the expansion of pancreatic ductal adenocarcinoma stem cells. [Mol Ther Oncolytics] Abstract | Full Article | Graphical Abstract

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Plasticity of Cancer Stem Cell: Origin and Role in Disease Progression and Therapy Resistance

The authors discuss how cancer cells acquire plasticity, especially the role of the normal developmental process, tumor microenvironment, and epigenetic changes in the development of plasticity. [Stem Cell Rev] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Incysus Therapeutics Announces Issuance of Foundational US Patent Covering Use of Drug Resistant Immunotherapy (DRI) Technology for the Treatment of Cancer

Incysus Therapeutics, Inc. announced that the United States Patent Office has issued US Patent Number 10,543,233 titled “Drug Resistant Immunotherapy for Treatment of a Cancer”. [Incysus Therapeutics, Inc. (GlobeNewswire, Inc.)] Press Release

Notable Launches The ANSWer Study: An Observational Clinical Trial for Patients with Blood Cancer and Enrolls First Patients

Notable is currently enrolling patients in its new observational clinical trial. The trial will take place at multiple sites across the country and will focus on hematologic malignancies. [Notable Labs (GlobeNewswire, Inc.)] Press Release

Top Harvard Chemist Charged with Lying about Ties to Chinese Government Program

The head of Harvard University’s chemistry department was charged with attempting to conceal his involvement in a Chinese government program to bring scientists to China, an escalation of a crackdown by US authorities on what they perceive as a campaign to steal ideas born in American universities and medical centers. [STAT News] Editorial

Iranian Students Denied Entry to US

Despite having valid visas to attend universities, more than a dozen would-be graduate students have been detained at the airport and sent back to Iran in recent months. [The Scientist] Editorial

NEW EACR-AACR Basic and Translational Research Conference 2020 Conference: Tumor Microenvironment
March 2-4, 2020
Lisbon, Portugal

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg)

Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Team Leader – Clonal Evolution in Leukemia (Institute of Cancer Research)

Research Fellow – Glioblastoma Cell Signaling (University of Sussex)

Postdoctoral Associate – Leukemia and Brain Tumors (Ann and Robert H. Lurie Children’s Hospital of Chicago)

Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai)

Postdoctoral Scholarship – Brain Tumor Stemness (Lund University)

Research Associate – Cell Communication in Tumor Microenvironments (The University of Cambridge)

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