Cancer Stem Cell News Volume 9.06 | Feb 19 2020

TOP STORY

Inhibiting WNT and NOTCH in Renal Cancer Stem Cells and the Implications for Human Patients

Scientists used cancer stem cells (CSCs) to establish non-adherent sphere cultures, 3D tumor organoids, and xenografts. Treatment with WNT and NOTCH inhibitors blocked the proliferation and self-renewal of CSCs in sphere cultures and organoids. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

FOXM1 Regulates Leukemia Stem Cell Quiescence and Survival in MLL-Rearranged AML

Inhibition of FOXM1 markedly suppressed leukemogenic potential and induced apoptosis of primary leukemia stem cells from mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML) patients in vitro and in vivo in xenograft mice. [Nat Commun] Full Article

MAOA-Mediated Reprogramming of Stromal Fibroblasts Promotes Prostate Tumorigenesis and Cancer Stemness

Monoamine oxidase A (MAOA) in stromal fibroblasts provided tumor cell growth advantages through paracrine IL-6/STAT3 signaling. Downstream of stromal MAOA, STAT3 promoted cell stemness and transcriptionally activated expression of cancer stem cell marker CD44 in prostate cancer cells. [Oncogene] Abstract

CUL4B Contributes to Cancer Stemness by Repressing Tumor Suppressor miR34a in Colorectal Cancer

Investigators aimed to identify the new regulators of colorectal cancer stem cells and found that Cullin 4B (CUL4B), which possessed oncogenic properties in multiple solid tumors, drove the development and metastasis of colon cancer by sustaining cancer stem-like features. [Oncogenesis] Full Article

Influence of the Human Papillomavirus on the Radio-Responsiveness of Cancer Stem Cells in Head and Neck Cancers

The authors examined dynamic responses in populations of a cancer stem cell phenotype in head and neck cancer cell lines following X-irradiation at therapeutic levels, and comparing between HPV statuses. [Sci Rep] Full Article

Nandrolone Induces a Stem Cell-Like Phenotype in Human Hepatocarcinoma-Derived Cell Line Inhibiting Mitochondrial Respiratory Activity

Researchers investigated the impact of nandrolone on the metabolic phenotype in a HepG2 cell line. Nandrolone caused a significant increase of stemness-markers in both 2D and 3D cultures. [Sci Rep] Full Article

Secretory Clusterin Promotes Hepatocellular Carcinoma Progression by Facilitating Cancer Stem Cell Properties via AKT/GSK-3β/β-Catenin Axis

A tumor sphere assay was performed to evaluate the self-renewal ability of hepatocellular carcinoma (HCC) cells. In addition, the molecular regulation between secretory clusterin and AKT/GSK-3β/β-catenin axis in HCC cells were discovered by western blotting, quantitative real-time PCR, and immunofluorescence. [J Transl Med] Full Article

Targeting Glioma-Initiating Cells via the Tyrosine Metabolic Pathway

Comprehensive metabolic analyses were performed on 20 high-grade glioma tissues and 30 glioma-initiating cell sphere culture models. Scientists suggested that tyrosine metabolism could serve as a possible therapeutic target in glioblastoma, particularly in the tumor core. [J Neurosurg] Abstract

Silencing MYH9 Blocks HBx-Induced GSK3β Ubiquitination and Degradation to Inhibit Tumor Stemness in Hepatocellular Carcinoma

Researchers found that MYH9 was an effective promoter of tumor stemness that facilitated hepatocellular carcinoma pathogenesis. Targeting MYH9 blocked HBX protein-induced GSK3β ubiquitination to activate the β-catenin destruction complex and suppressed cancer stemness and EMT. [Signal Transduct Target Ther] Full Article

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Novel Ablation Methods for Treatment of Gliomas

The authors review the most common primary brain tumors, as a need exists for new approaches to tumor therapy that can circumvent the blood brain barrier, target highly resistant tumors and cancer stem-like cells as well create an anti-cancer immunomodulatory environment. [J Neurosci Methods] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

US Food and Drug Administration (FDA) Accepts for Priority Review Bristol-Myers Squibb’s Biologics License Application (BLA) for Lisocabtagene Maraleucel (Liso-Cel) for Adult Patients with Relapsed or Refractory Large B-Cell Lymphoma

Bristol-Myers Squibb Company announced that the FDA has accepted for Priority Review its BLA for liso-cel, the company’s autologous anti-CD19 chimeric antigen receptor (CAR) T-cell immunotherapy with a defined composition of purified CD8⁺ and CD4⁺ CAR T cells for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after at least two prior therapies. [Bristol-Myers Squibb Company] Press Release

Merck Receives Complete Response Letter from the US FDA for Supplemental Biologics License Applications (sBLAs) for KEYTRUDA^® (Pembrolizumab) Six-Week Dosing Schedule

Merck, Inc. announced that the FDA has issued a Complete Response Letter regarding Merck’s sBLAs seeking to update the dosing frequency for KEYTRUDA^®, Merck’s anti-PD-1 therapy, to include a 400 mg dose infused over 30 minutes every-six-weeks option in multiple indications. [Merck, Inc.] Press Release

The Next Chapter for African Genomics

Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way. [Nature News] Editorial

‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide

Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial

NEW Keystone Symposia: Hematopoiesis
April 3-7, 2020
Big Sky, Montana, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Cancer Cell Invasiveness and Cancer Stem Cells (Cancer Research Center of Lyon)

NEW Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University)

Postdoctoral Research Fellowship – Cancer Biology and Stem Cell Biology (UT Southwestern Medical Center)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg)

Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Postdoctoral Associate – Leukemia and Brain Tumors (Ann and Robert H. Lurie Children’s Hospital of Chicago)

Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai)

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