|Cancer Stem Cell News 9.07 February 26, 2020|
Scientists use single-cell transcriptome and epitope profiling together with pathway and lineage analyses to study tumorigenesis from a developmental perspective in a mouse model of salivary gland squamous cell carcinoma. [Nat Commun]
Clonal tracking identified subsets of self-renewing tumor-initiating cells in the bone marrow (BM) that formed tumors out of BM transplants, including one subset that did not drive primary tumor growth. [Int J Cancer]
Pimozide suppressed the formation of 3D osteospheres and growth of the cells in the Tumor in a Dish lung organoid system. There was a reduction in expression of cancer stem cell marker proteins DCLK1, CD44, CD133, Oct-4, and ABCG2. [Cell Death Dis]
Researchers used time-lapse microscopy to evaluate the migratory behavior of cancer stem cells, with a focus on identifying key regulators of migration. [Cell Death Dis]
The authors evaluated the biological activity of compounds against transformed human mammary epithelial HMLER CD24 low/CD44 high cells, a well-established model of breast cancer stem cells. [Chemistry]
Researchers identified inhibitors of the divalent metal transporter 1 (DMT1) that selectively targeted cancer stem cells by blocking lysosomal iron translocation. [Chemistry]
Overexpression of GRP78 in breast cancer cells led to an induction of a CD24–/CD44+ tumor initiating cell population and sGRP78+ breast cancer cells were enriched for stemness genes. [Sci Rep]
Investigators examined the therapeutic effect of anti-claudin-4 extracellular domain antibody, 4D3, on triple negative breast cancer. 4D3 reduced stemness of the tumors in association with increase in the intratumoral pH. [Cancer Sci]
Scientists investigated the efficacy of a dual intervention against EGFR and HER2 to deplete tumor-initiating cells, optimize the chemotherapy management and prevent progression of castration-resistant prostate cancer cells. [Cancer Biol Ther]
Investigators found that NOTCH1 signaling was activated in sorafenib-resistant hepatocellular carcinoma cells and NOTCH1 activation conferred hepatoma cells sorafenib resistance through enhanced self-renewal and tumorigenecity. [Transl Oncol]
The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. [Adv Med Sci]
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SELLAS Life Sciences Group, Inc. announced final follow-up data for its Phase I/II study of GPS in patients with acute myeloid leukemia in second complete remission. [SELLAS Life Sciences Group, Inc.]
Through Moleculin Biotech, Inc., WPD’s license partner, the WP1066 drug candidate received FDA approval for Investigational New Drug status to be used in a Phase I clinical trial for the treatment of children with recurrent or refractory malignant brain tumors. [WPD Pharmaceuticals Inc.]
For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a ten year gap in data that now must be made publicly available. [STAT News]
It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News]
NEW American Association for Cancer Research (AACR) Annual Meeting 2020
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