Cancer Stem Cell News Volume 9.07 | Feb 26 2020

TOP STORY

Tracing Tumorigenesis in a Solid Tumor Model at Single-Cell Resolution

Scientists use single-cell transcriptome and epitope profiling together with pathway and lineage analyses to study tumorigenesis from a developmental perspective in a mouse model of salivary gland squamous cell carcinoma. [Nat Commun] Full Article | Press Release

(Ranked by impact factor of the journal)

A Perivascular Niche in the Bone Marrow Hosts Quiescent and Proliferating Tumorigenic Colorectal Cancer Cells

Clonal tracking identified subsets of self-renewing tumor-initiating cells in the bone marrow (BM) that formed tumors out of BM transplants, including one subset that did not drive primary tumor growth. [Int J Cancer] Abstract

Suppressing STAT5 Signaling Affects Osteosarcoma Growth and Stemness

Pimozide suppressed the formation of 3D osteospheres and growth of the cells in the Tumor in a Dish lung organoid system. There was a reduction in expression of cancer stem cell marker proteins DCLK1, CD44, CD133, Oct-4, and ABCG2. [Cell Death Dis] Full Article

Identifying Conserved Molecular Targets Required for Cell Migration of Glioblastoma Cancer Stem Cells

Researchers used time-lapse microscopy to evaluate the migratory behavior of cancer stem cells, with a focus on identifying key regulators of migration. [Cell Death Dis] Full Article

Salinomycin Derivatives Kill Breast Cancer Stem Cells via Lysosomal Iron Targeting

The authors evaluated the biological activity of compounds against transformed human mammary epithelial HMLER CD24 low/CD44 high cells, a well-established model of breast cancer stem cells. [Chemistry] Abstract

DMT1 Inhibitors Kill Cancer Stem Cells by Blocking Lysosomal Iron Translocation

Researchers identified inhibitors of the divalent metal transporter 1 (DMT1) that selectively targeted cancer stem cells by blocking lysosomal iron translocation. [Chemistry] Abstract

Cell Surface GRP78 Promotes Stemness in Normal and Neoplastic Cells

Overexpression of GRP78 in breast cancer cells led to an induction of a CD24^–/CD44⁺ tumor initiating cell population and sGRP78⁺ breast cancer cells were enriched for stemness genes. [Sci Rep] Full Article

Targeting Claudin-4 Enhances Chemosensitivity in Breast Cancer

Investigators examined the therapeutic effect of anti-claudin-4 extracellular domain antibody, 4D3, on triple negative breast cancer. 4D3 reduced stemness of the tumors in association with increase in the intratumoral pH. [Cancer Sci] Abstract

Combined Targeting of EGFR and HER2 against Prostate Cancer Stem Cells

Scientists investigated the efficacy of a dual intervention against EGFR and HER2 to deplete tumor-initiating cells, optimize the chemotherapy management and prevent progression of castration-resistant prostate cancer cells. [Cancer Biol Ther] Abstract

Inhibition of EZH2 Attenuates Sorafenib Resistance by Targeting NOTCH1 Activation-Dependent Liver Cancer Stem Cells via NOTCH1-Related MicroRNAs in Hepatocellular Carcinoma

Investigators found that NOTCH1 signaling was activated in sorafenib-resistant hepatocellular carcinoma cells and NOTCH1 activation conferred hepatoma cells sorafenib resistance through enhanced self-renewal and tumorigenecity. [Transl Oncol] Full Article

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Role of Apelin/APJ Axis in Cancer Development and Progression

The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. [Adv Med Sci] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

SELLAS Announces Positive Follow-Up Phase I/II Clinical Data for Galinpepimut-S (GPS) in Acute Myeloid Leukemia (AML)

SELLAS Life Sciences Group, Inc. announced final follow-up data for its Phase I/II study of GPS in patients with acute myeloid leukemia in second complete remission. [SELLAS Life Sciences Group, Inc.] Press Release

WPD Pharmaceuticals’ STAT3 Inhibitor Received FDA Approval of IND Status in Pediatric Brain Cancer Trial

Through Moleculin Biotech, Inc., WPD’s license partner, the WP1066 drug candidate received FDA approval for Investigational New Drug status to be used in a Phase I clinical trial for the treatment of children with recurrent or refractory malignant brain tumors. [WPD Pharmaceuticals Inc.] Press Release

Federal Judge Rules Clinical Trial Sponsors Must Publish a Decade’s Worth of Missing Data

For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a ten year gap in data that now must be made publicly available. [STAT News] Editorial

Contract Offers Unprecedented Look at Google Deal to Obtain Patient Data from the University of California

It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News] Editorial

NEW American Association for Cancer Research (AACR) Annual Meeting 2020
April 24-29, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester)

NEW Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg)

Postdoctoral Researcher – Cancer Cell Invasiveness and Cancer Stem Cells (Cancer Research Center of Lyon)

Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University)

Postdoctoral Research Fellowship – Cancer Biology and Stem Cell Biology (UT Southwestern Medical Center)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg)

Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai)

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