Cancer Stem Cell News 9.07 February 26, 2020 | |
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TOP STORYTracing Tumorigenesis in a Solid Tumor Model at Single-Cell Resolution Scientists use single-cell transcriptome and epitope profiling together with pathway and lineage analyses to study tumorigenesis from a developmental perspective in a mouse model of salivary gland squamous cell carcinoma. [Nat Commun] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Clonal tracking identified subsets of self-renewing tumor-initiating cells in the bone marrow (BM) that formed tumors out of BM transplants, including one subset that did not drive primary tumor growth. [Int J Cancer] Abstract Suppressing STAT5 Signaling Affects Osteosarcoma Growth and Stemness Pimozide suppressed the formation of 3D osteospheres and growth of the cells in the Tumor in a Dish lung organoid system. There was a reduction in expression of cancer stem cell marker proteins DCLK1, CD44, CD133, Oct-4, and ABCG2. [Cell Death Dis] Full Article Researchers used time-lapse microscopy to evaluate the migratory behavior of cancer stem cells, with a focus on identifying key regulators of migration. [Cell Death Dis] Full Article Salinomycin Derivatives Kill Breast Cancer Stem Cells via Lysosomal Iron Targeting The authors evaluated the biological activity of compounds against transformed human mammary epithelial HMLER CD24 low/CD44 high cells, a well-established model of breast cancer stem cells. [Chemistry] Abstract DMT1 Inhibitors Kill Cancer Stem Cells by Blocking Lysosomal Iron Translocation Researchers identified inhibitors of the divalent metal transporter 1 (DMT1) that selectively targeted cancer stem cells by blocking lysosomal iron translocation. [Chemistry] Abstract Cell Surface GRP78 Promotes Stemness in Normal and Neoplastic Cells Overexpression of GRP78 in breast cancer cells led to an induction of a CD24–/CD44+ tumor initiating cell population and sGRP78+ breast cancer cells were enriched for stemness genes. [Sci Rep] Full Article Targeting Claudin-4 Enhances Chemosensitivity in Breast Cancer Investigators examined the therapeutic effect of anti-claudin-4 extracellular domain antibody, 4D3, on triple negative breast cancer. 4D3 reduced stemness of the tumors in association with increase in the intratumoral pH. [Cancer Sci] Abstract Combined Targeting of EGFR and HER2 against Prostate Cancer Stem Cells Scientists investigated the efficacy of a dual intervention against EGFR and HER2 to deplete tumor-initiating cells, optimize the chemotherapy management and prevent progression of castration-resistant prostate cancer cells. [Cancer Biol Ther] Abstract Investigators found that NOTCH1 signaling was activated in sorafenib-resistant hepatocellular carcinoma cells and NOTCH1 activation conferred hepatoma cells sorafenib resistance through enhanced self-renewal and tumorigenecity. [Transl Oncol] Full Article Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSRole of Apelin/APJ Axis in Cancer Development and Progression The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. [Adv Med Sci] Full Article Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSSELLAS Life Sciences Group, Inc. announced final follow-up data for its Phase I/II study of GPS in patients with acute myeloid leukemia in second complete remission. [SELLAS Life Sciences Group, Inc.] Press Release Through Moleculin Biotech, Inc., WPD’s license partner, the WP1066 drug candidate received FDA approval for Investigational New Drug status to be used in a Phase I clinical trial for the treatment of children with recurrent or refractory malignant brain tumors. [WPD Pharmaceuticals Inc.] Press Release | |
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POLICY NEWSFederal Judge Rules Clinical Trial Sponsors Must Publish a Decade’s Worth of Missing Data For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a ten year gap in data that now must be made publicly available. [STAT News] Editorial It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News] Editorial
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EVENTSNEW American Association for Cancer Research (AACR) Annual Meeting 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester) NEW Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg) Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University) Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University) Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University) Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg) Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute) Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation) Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute) Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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