Cancer Stem Cell News Volume 9.09 | Mar 11 2020

TOP STORY

Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis

Chemical carcinogenesis of the stomach was associated with loss of gastrin-expressing endocrine cells, increased symmetric stem cell division, glandular fission, and more rapid stem cell lineage tracing. [Cell Stem Cell] Abstract | Graphical Abstract

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Identification of Sca-1⁺Abcg1⁺ Bronchioalveolar Epithelial Cells as the Origin of Lung Adenocarcinoma in Gprc5a-Knockout Mouse Model through the Interaction between Lung Progenitor AT2 and Lgr5 Cells

Scientists proposed a new therapeutic strategy: investigating the “transitional” cells that represented the stage between normal lung stem cells and lung CSCs. [Oncogene] Full Article

Drosha-Independent miR-6778-5p Strengthens Gastric Cancer Stem Cell Stemness via Regulation of Cytosolic One-Carbon Folate Metabolism

Investigators report that miR-6778-5p, a noncanonical miRNA, acted as a crucial regulator for maintenance of cancer stem cell stemness in Drosha-silenced gastric cancer cells. [Cancer Lett] Full Article

Pyridoxine Enhances Chemo-Responsiveness of Breast Cancer Stem Cells via Redox Reconditioning

Scientists observed that breast CSCs were resistant to DNA damage and generated low ROS upon doxorubicin treatment. [Free Radic Biol Med] Abstract | Graphical Abstract

Regulation of Cancer Stem Cell Properties, Angiogenesis, and Vasculogenic Mimicry by miR-450a-5p/SOX2 Axis in Colorectal Cancer

Knockdown of sex-determining region Y-box2 (SOX2) ceased stemness properties, angiogenesis, and vasculogenic mimicry, along with decreased expression of CD133, CD31, and VE-cadherin as observed in functional experiments. [Cell Death Dis] Full Article

Long Noncoding RNA LINC00324 Exerts Protumorigenic Effects on Liver Cancer Stem Cells by Upregulating Fas Ligand via PU Box Binding Protein

The expression of LINC00324 in hepatocellular carcinoma tissues and liver cancer stem cell lines was examined using RT-qPCR. The interaction among LINC00324, PU box binding protein and FasL was identified with RIP, ChIP and dual-luciferase reporter gene assays. [FASEB J] Full Article

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Researchers explored cell-to-cell Wnt and stemness heterogeneity in hepatocellular carcinoma by labeling freshly isolated cancer cells with a Wnt-specific reporter. [Stem Cell Reports] Full Article

Impact of the Monocarboxylate Transporter-1 (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells

The lactate dependent effects on stemness properties were abrogated by the MCT1/lactate-uptake inhibitor 7ACC2 or MCT1 knock-down. [Cancers] Abstract | Full Article Download

Small Molecule-Induced Simultaneous Destabilization of β-Catenin and RAS Is an Effective Molecular Strategy to Suppress Stemness of Colorectal Cancer Cells

Treatment with KYA1797K, a small molecule that destabilized both β-catenin and RAS via Axin binding, effectively suppressed the stemness of CSCs as was shown in colorectal cancer spheroids and small intestinal tumors. [Cell Commun Signal] Full Article

Induction of Immunogenic Cell Death in Radiation-Resistant Breast Cancer Stem Cells by Repurposing Anti-Alcoholism Drug Disulfiram

Flow sorted breast CSCs and non-breast CSCs were tested for their characteristic of stemness by mammosphere formation assay. [Cell Commun Signal] Full Article

Cancer Stem Cell Enrichment Is Associated with Enhancement of Nicotinamide N-Methyltransferase Expression

A culture system was setup to enrich CSCs from bladder cancer, lung cancer, colorectal cancer, and osteosarcoma cell lines, through sphere formation. [IUBMB Life] Abstract

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A Perspective on Challenges and Opportunities in Characterizing Oral Cancer Stem Cells

The authors discuss different markers, CD44, ALDH1, CD271 and others that have used for identifying and isolating CSCs from primary head and neck, and oral squamous cell carcinomas. [Front Biosci] Full Article

Alterations of Cell Cycle Genes in Cancer: Unmasking the Role of Cancer Stem Cells

Scientists describe epigenetic alterations and aberrant transcriptional regulation of cell cycle genes in CSCs as well as cell cycle patterns of CSCs. [Mol Biol Rep] Abstract

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CCNY-MSKCC Cancer Research Partnership Receives $14M NIH Grant

The grant will fund a new research education program for City College students and ongoing cancer outreach in the Harlem community. [The City College of New York] Press Release

CPRIT Awards Research Grant to Texas Tech HSC’s Reynolds

The Cancer Prevention and Research Institute of Texas (CPRIT) in February announced a $1,196,214 grant to C. Patrick Reynolds, M.D., Ph.D., director for the School of Medicine Cancer Center at the Texas Tech University Health Sciences Center (TTUHSC). [Texas Tech University Health Sciences Center] Press Release

New Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone

President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial

Clinical Research Company Sued over Stolen Trade Secrets after Employee Filmed Dogs Used in Experiments

Nearly two years ago, Charles River Laboratories paid $800 million for a company called MPI Research to bolster its business running clinical trials for drug makers and other companies. But Charles River did not know one MPI employee was an also undercover agent for the Humane Society of the United States and secretly filmed experiments conducted on various dogs, which were later publicized on the internet. [STAT News] Editorial

NEW Diverse Organisms and Common Mechanisms in Cell-Cell Fusion
May 31-June 5, 2020
Easton, Massachusetts, United States

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NEW Research Fellow – Leukemia Stem Cell Research (Dana Farber Cancer Institute)

Postdoctoral Fellow – Breast Cancer Stem Cells (Albert Einstein College of Medicine)

Research Fellow – Leukemia Stem Cell Biology (University College London)

Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester)

Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg)

Postdoctoral Researcher – Cancer Cell Invasiveness and Cancer Stem Cells (Cancer Research Center of Lyon)

Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University)

Postdoctoral Research Fellowship – Cancer Biology and Stem Cell Biology (UT Southwestern Medical Center)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg)

Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

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