|Cancer Stem Cell News 9.13 April 8, 2020|
Scientists found that glioblastoma stem cells within the glioblastoma cerebral organoids model were enriched for a neural progenitor-like cell subpopulation and recapitulated the cellular states and their plasticity found in the corresponding primary parental tumors. [Cancer Discov]
Scientists demonstrated that aberrant prominin-1 (PROM1)/CD133 expression was essential for leukemic cell growth, mediated by direct binding of MLL-AF4. [Leukemia]
RNA silencing was performed using siRNA or lentiviral constructs in U87MG and U251 glioma cell lines and GSC267 glioma stem cells. Gene silencing of CUL7 in U87MG and U251 cells significantly inhibited tumor growth, invasion and migration in vitro and in vivo. [J Exp Clin Cancer Res]
Chemotherapy was found to not only kill tumor cells, but also trigger the induction of CSC-like traits and the migration of ovarian cancer cells. [Br J Cancer]
Investigators reported the higher frequency of mature tumor cells and CSCs expressing the investigated immunomodulating molecules in metastatic lymph nodes than in nonmetastatic. [Cancers]
The authors hypothesized that the novel C-terminal HSP90 inhibitors KU711 and KU758 could target tumor initiating cells and represented a promising strategy for overcoming metastasis. [Mol Oncol]
The authors investigated the mechanism underlying stemness acquisition in glioblastoma multiform (GBM) cells by focusing on 40S ribosomal protein S6 (RPS6). RPS6 was significantly upregulated in high-grade glioma and localized at perivascular, perinecrotic, and border niches in GBM tissues. [Cancer Sci]
Leukemia stem cells were prominently detected in the bone marrow cells (BMCs) isolated from patients with acute myeloid leukemia and chronic myeloid leukemia, but rarely in BMCs isolated from patients with diffuse large B-cell lymphoma, multiple myeloma, myelodysplastic syndrome, acute lymphocytic leukemia, chronic lymphocytic leukemia, and Hodgkin lymphoma. [BMC Cancer]
The authors review experimental evidence aiming to define the origins of skin and esophageal cancers and discuss how cyclooxygenase-2 (Cox-2) contributes to tumorigenesis and differentiation. [Exp Mol Med]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Ascentage Pharma Announces Approval for the Phase Ib/II Clinical Study of Bcl-2 Inhibitor APG-2575 for the Treatment of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma in China
Ascentage Pharma announced that it has received approval from the Center for Drug Evaluation of the China National Medical Products Administration for the Phase Ib/II study of APG-2575, the company’s novel Bcl-2-selective inhibitor, for the treatment of patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. [Ascentage Pharma (PR Newswire Association LLC)]
Gracell Biotechnologies Co. announced that China National Medical Products Administration has accepted Gracell’s Investigational New Drug application for GC007g, a donor-derived anti-CD19 chimeric antigen receptor cell therapy. [Gracell Biotechnologies Co. (PR Newswire Association LLC)]
Ryvu Therapeutics announced that the FDA has granted an orphan drug designation to Ryvu’s SEL120, for the treatment of patients with acute myeloid leukemia. [Ryvu Therapeutics]
For some scientists, the shutdowns have made it more challenging for them to complete their work. But for others, they come at a critical juncture in the scientist’s career, threatening to derail or delay a major event along their professional path-a small slice of the human suffering and inconvenience that COVID-19 has caused. [ScienceInsider]
Some scientists can’t simply stop going to their laboratories – especially not those who are overseeing clinical trials that could offer life-saving vaccines and therapies, particularly against the new coronavirus. And some research activities must continue even in the face of a shutdown. [Nature News]
In light of COVID-19, many conferences are being cancelled or postponed. As such:
We are suspending new event postings in our newsletters and on Twitter.
Visit our events page to see a complete list of events in the community.
Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!
Comments or suggestions? Submit your feedback here.