|Cancer Stem Cell News 9.18 May 13, 2020|
Researchers identified the capacity to synthesize proteins as a key property for the regenerative potential of colon cancer cells. [Press release from the Institute for Research in Biomedicine discussing online prepublication in Cell Stem Cell]
Scientists demonstrated that ALKBH5 was required for the development and maintenance of acute myeloid leukemia and self-renewal of leukemia stem/initiating cells but not essential for normal hematopoiesis. [Cell Stem Cell]
Investigators showed that mouse intestinal tumors carrying Trp53 gain-of-function mutation with loss of heterozygosity were enriched in metastatic lesions when heterozygous Trp53 mutant cells were transplanted. [Nat Commun]
circZNF609 was conspicuously overexpressed and featured with loop structure in hepatocellular carcinoma (HCC). Functional tests revealed that decreased expression of circZNF609 suppressed cell proliferation, metastasis and stemness, whereas induced cell apoptosis in HCC. [Cell Death Dis]
Researchers explored whether LGR5+ epithelial cells in ameloblastoma (AM) possess stem-like cell properties and their potential contribution to pathogenesis and recurrence of AM. [Cell Death Dis]
The authors demonstrated enhanced CSC characteristics of tumor cells derived from ovarian cancer ascites, concomitant with ALDH and CD44 subset enrichment and high pyruvate dehydrogenase kinase 4 (PDK4) expression, compared to primary tumors. [Br J Cancer]
Catechol suppressed epithelial-mesenchymal transition-related steps such as migration, invasion, anoikis resistance acquisition, and stem cell-like characterization through the EGFR-AKT-ERK signaling pathway during liver cancer metastasis. [Sci Rep]
In order to verify that the Wnt/β-catenin signaling pathway was inhibited by endostain in 5637 bladder cancer cells and stem cells, the Wnt/β-catenin signaling pathway-associated molecules, including DKK1, LRP5, TCF4, β-catenin, cyclin D1, and c-Myc, were evaluated in 5637 bladder cancer cells and stem cells. [Mol Biol Rep]
The authors explored the function of SPHK1 in breast CSCs and non-CSCs. They showed that RNAi-mediated knockdown of SPHK1 inhibited cell proliferation and induced apoptosis in both breast CSCs and non-CSCs, while ectopic expression of SPHK1 enhanced breast CSC survival and mammosphere forming efficiency. [Cells]
Scientists focus on the pathways involved in expression of ALCAM and its prognostic value of in different types of cancers and the way in which it is regulated. [Exp Mol Pathol]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Cardiff Oncology, Inc. announced an agreement with PoC Capital, LLC, to fund the completion of its ongoing Phase Ib/II clinical trial in patients with KRAS-mutated mCRC. [Cardiff Oncology, Inc.]
Incysus Therapeutics, Inc. announced that the first patient in a Phase I clinical study titled, “Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide” has been treated at The University of Kansas Cancer Center. [Incysus Therapeutics, Inc. (GlobeNewswire, Inc.)]
Research in Australia will face drastic cuts in funding and jobs as a consequence of the COVID-19 pandemic and economic shut-downs, according to a report by organizations representing the country’s researchers and academia. [Nature News]
A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider]
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