Cancer Stem Cell News Volume 9.18 | May 13 2020

TOP STORY

Biosynthetic Capacity: The Key to Switch-Off Cancer Stem Cells

Researchers identified the capacity to synthesize proteins as a key property for the regenerative potential of colon cancer cells. [Press release from the Institute for Research in Biomedicine discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

Scientists demonstrated that ALKBH5 was required for the development and maintenance of acute myeloid leukemia and self-renewal of leukemia stem/initiating cells but not essential for normal hematopoiesis. [Cell Stem Cell] Abstract | Graphical Abstract

Loss of Wild-Type p53 Promotes Mutant p53-Driven Metastasis through Acquisition of Survival and Tumor-Initiating Properties

Investigators showed that mouse intestinal tumors carrying Trp53 gain-of-function mutation with loss of heterozygosity were enriched in metastatic lesions when heterozygous Trp53 mutant cells were transplanted. [Nat Commun] Full Article

CircZNF609 Enhances Hepatocellular Carcinoma Cell Proliferation, Metastasis, and Stemness by Activating the Hedgehog Pathway through the Regulation of miR-15a-5p/15b-5p and GLI2 Expressions

circZNF609 was conspicuously overexpressed and featured with loop structure in hepatocellular carcinoma (HCC). Functional tests revealed that decreased expression of circZNF609 suppressed cell proliferation, metastasis and stemness, whereas induced cell apoptosis in HCC. [Cell Death Dis] Full Article

LGR5⁺ Epithelial Tumor Stem-Like Cells Generate a 3D-Organoid Model for Ameloblastoma

Researchers explored whether LGR5⁺ epithelial cells in ameloblastoma (AM) possess stem-like cell properties and their potential contribution to pathogenesis and recurrence of AM. [Cell Death Dis] Full Article

Ascites-Derived ALDH⁺CD44⁺ Tumor Cell Subsets Endow Stemness, Metastasis and Metabolic Switch via PDK4-Mediated STAT3/AKT/NF-κB/IL-8 Signaling in Ovarian Cancer

The authors demonstrated enhanced CSC characteristics of tumor cells derived from ovarian cancer ascites, concomitant with ALDH and CD44 subset enrichment and high pyruvate dehydrogenase kinase 4 (PDK4) expression, compared to primary tumors. [Br J Cancer] Abstract

Catechol Inhibits Epidermal Growth Factor-Induced Epithelial-to-Mesenchymal Transition and Stem Cell-Like Properties in Hepatocellular Carcinoma Cells

Catechol suppressed epithelial-mesenchymal transition-related steps such as migration, invasion, anoikis resistance acquisition, and stem cell-like characterization through the EGFR-AKT-ERK signaling pathway during liver cancer metastasis. [Sci Rep] Full Article

Effect of Endostatin on Wnt Pathway of Stem-Like Cells in Bladder Cancer in Tumor Microenvironment

In order to verify that the Wnt/β-catenin signaling pathway was inhibited by endostain in 5637 bladder cancer cells and stem cells, the Wnt/β-catenin signaling pathway-associated molecules, including DKK1, LRP5, TCF4, β-catenin, cyclin D1, and c-Myc, were evaluated in 5637 bladder cancer cells and stem cells. [Mol Biol Rep] Abstract

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-Stem Breast Cancer Cells by Suppression of STAT1

The authors explored the function of SPHK1 in breast CSCs and non-CSCs. They showed that RNAi-mediated knockdown of SPHK1 inhibited cell proliferation and induced apoptosis in both breast CSCs and non-CSCs, while ectopic expression of SPHK1 enhanced breast CSC survival and mammosphere forming efficiency. [Cells] Full Article

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The Role of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Cancer Progression, Invasion, Metastasis and Recurrence: A Novel Cancer Stem Cell Marker and Tumor-Specific Prognostic Marker

Scientists focus on the pathways involved in expression of ALCAM and its prognostic value of in different types of cancers and the way in which it is regulated. [Exp Mol Pathol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Cardiff Oncology Enters Agreement with PoC Capital to Fund Phase II Clinical Trial of Onvansertib in KRAS-Mutated Metastatic Colorectal Cancer (mCRC)

Cardiff Oncology, Inc. announced an agreement with PoC Capital, LLC, to fund the completion of its ongoing Phase Ib/II clinical trial in patients with KRAS-mutated mCRC. [Cardiff Oncology, Inc.] Press Release

Incysus Therapeutics Treats First Patient in Phase I Study of Gamma Delta (γδ) T Cell Immunotherapy in Leukemia and Lymphoma Patients Undergoing Allogeneic Stem Cell Transplantation

Incysus Therapeutics, Inc. announced that the first patient in a Phase I clinical study titled, “Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide” has been treated at The University of Kansas Cancer Center. [Incysus Therapeutics, Inc. (GlobeNewswire, Inc.)] Press Release

Coronavirus Shut-Downs Pose Huge Threat to Australian Research Jobs

Research in Australia will face drastic cuts in funding and jobs as a consequence of the COVID-19 pandemic and economic shut-downs, according to a report by organizations representing the country’s researchers and academia. [Nature News] Editorial

Secretive Jasons to Offer Advice on How to Reopen Academic Labs Shut by Pandemic

A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider] Editorial

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NEW Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

NEW Postdoctoral Position – Bioinformatics and Computational Biology of Stem Cell and Cancer Epigenetics (Albert Einstein College of Medicine)

NEW Postdoctoral Fellow – Stem Cell and Leukemia Metabolism (Children’s Medical Center Research Institute)

Postdoctoral Scholarship – RNA Biology in Stem Cells and Cancer Models (University of Gothenburg)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Fellowship – Leukemia Stem Cell Research (Josep Carreras Leukaemia Research Institute)

PhD Positions – Head and Neck Cancer Stem Cells (The Mildred Scheel Nachwuchszentrum for Cancer Research)

Scientist – Stem Cells and Cellular Biology (Athersys, Inc.)

Postdoctoral Positions – DNA Repair in Leukemia (Temple University School of Medicine)

Associate Professor – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Position – Glioma Epigenomic Research (NIH National Cancer Institute)

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