Cancer Stem Cell News 9.22 June 10, 2020 | |
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TOP STORYTo parse the function of macrophages in 3D, the authors compared the growth of glioblastoma stem cells alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel, with or without macrophages. [Cell Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the value of a proprietary approach ‐ cell surface vimentin positive circulating tumor cells to monitor treatment response and predict relapse in neuroblastoma patients under remission in a Phase II long‐term preventative clinical trial. [Int J Cancer] Abstract ZSCAN4 Facilitates Chromatin Remodeling and Promotes the Cancer Stem Cell Phenotype The authors investigated the role of Zinc finger and SCAN domain containing 4 (ZSCAN4) in human head and neck squamous cell carcinoma. [Oncogene] Full Article Researchers report that a remarkable increase in PIK3C3 was detected in hepatocellular carcinoma (HCC) tissues and liver CSCs. Upregulated PIK3C3 facilitated liver CSC expansion in HCC cells; RNA interference-mediated silencing of PIK3C3 had an opposite effect. [Cell Death Dis] Full Article Immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions deepened. Ectopic expression of HOXA5 restrained cell proliferation, decreased cell viability, and inhibited tumor formation in vitro and in vivo. [Cell Death Dis] Full Article Investigators describe the generation of highly metastatic pancreatic ductal adenocarcinoma patient-derived xenograft mouse models and subsequent single-cell RNA sequencing of circulating tumor cells, isolated by human HLA sorting, to identify altered signaling and metabolic pathways as well as potential therapeutic targets. [Mol Cancer Ther] Abstract A highly validated CSC model (FGβ3 cells) was used to test a novel compound to eradicate CSCs. Compared to parental bulk FG cells, PAWI-2 showed greater potency to inhibit cell viability and self-renewal capacity of FGβ3 cells. [Sci Rep] Full Article Scientists determined the influence of mRNA-assessed intrinsic subtype stability comparing primary tumor and metastatic tumor biopsies and circulating tumor cell-based liquid biopsies on progression free survival and overall survival. [Diagnostics (Basel)] Full Article The authors investigated the use of a folate receptor-targeted fluorescence molecular probe for in vivo labeling of folate receptor positive circulating tumor cells for diffuse in vivo flow cytometry. [Mol Imaging Biol] Abstract Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSCTCF-Mediated Genome Organization and Leukemogenesis The authors highlight the role of CCCTC-binding factor (CTCF) and its associated protein complexes in three-dimensional genome organization in development and leukemogenesis, as well as the roles of CTCF boundary defined topologically associated domain in transcription regulation. [Leukemia] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSNeurotrope, Inc. announced its entry into a strategic agreement with BryoLogyx Inc. for the supply of synthetic, GMP-certified Bryostatin-1. [Neurotrope, Inc. (PR Newswire Association LLC.)] Press Release ERYTECH Pharma provided an update on the ongoing Phase II trial, sponsored by the Nordic Society of Paediatric Haematology and Oncology of eryaspase in second-line acute lymphoblastic leukemia patients. [ERYTECH Pharma (Globe Newswire, Inc.)] Press Release | |
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POLICY NEWSAs Pandemic Pounds US Universities, Federal Support Helps Their Labs Stay Afloat This spring, as the coronavirus pandemic shuttered US higher education, many college presidents began to warn of the dire financial impact of a frozen US economy on their institutions. Their mix of revenue sources largely determined how much they might be hurt. [ScienceInsider] Editorial NIH Grapples with Rush to Claim Billions in Pandemic Research Funds For the second time in just over 10 years, the National Institutes of Health (NIH) is scrambling to hand out billions of dollars in emergency research funding and scientists are rushing to get a piece of the action—even as some confusion and concerns abound. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellowship – Cancer Biology (Massachusetts General Hospital) Faculty and Postdoctoral Positions – Stem Cells and Cancer (Shanghai Jiao Tong University) PhD Student Position – Leukemic Stem Cell Immune Targeting (Karolinska Institutet) Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope) Postdoctoral Position – Epigenetic Control of Cancer Stem Cell Biology (University of Freiburg) Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation) Postdoctoral Fellowship – Leukemia Stem Cell Research (Josep Carreras Leukaemia Research Institute) Scientist – Stem Cells and Cellular Biology (Athersys, Inc.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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