Cancer Stem Cell News Volume 9.22 | Jun 10 2020

TOP STORY

Three-Dimensional Bioprinted Glioblastoma Microenvironments Model Cellular Dependencies and Immune Interactions

To parse the function of macrophages in 3D, the authors compared the growth of glioblastoma stem cells alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel, with or without macrophages. [Cell Res] Abstract

(Ranked by impact factor of the journal)

Cell Surface Vimentin Positive Circulating Tumor Cell‐Based Relapse Prediction in a Long‐Term Longitudinal Study of Post‐Remission Neuroblastoma Patients

Scientists investigated the value of a proprietary approach ‐ cell surface vimentin positive circulating tumor cells to monitor treatment response and predict relapse in neuroblastoma patients under remission in a Phase II long‐term preventative clinical trial. [Int J Cancer] Abstract

ZSCAN4 Facilitates Chromatin Remodeling and Promotes the Cancer Stem Cell Phenotype

The authors investigated the role of Zinc finger and SCAN domain containing 4 (ZSCAN4) in human head and neck squamous cell carcinoma. [Oncogene] Full Article

PIK3C3 Regulates the Expansion of Liver CSCs and PIK3C3 Inhibition Counteracts Liver Cancer Stem Cell Activity Induced by PI3K Inhibitor

Researchers report that a remarkable increase in PIK3C3 was detected in hepatocellular carcinoma (HCC) tissues and liver CSCs. Upregulated PIK3C3 facilitated liver CSC expansion in HCC cells; RNA interference-mediated silencing of PIK3C3 had an opposite effect. [Cell Death Dis] Full Article

HOXA5 Inhibits the Proliferation and Neoplasia of Cervical Cancer Cells via Downregulating the Activity of the Wnt/β-Catenin Pathway and Transactivating TP53

Immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions deepened. Ectopic expression of HOXA5 restrained cell proliferation, decreased cell viability, and inhibited tumor formation in vitro and in vivo. [Cell Death Dis] Full Article

Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single Cell Transcriptomics Analysis of Circulating Tumor Cells

Investigators describe the generation of highly metastatic pancreatic ductal adenocarcinoma patient-derived xenograft mouse models and subsequent single-cell RNA sequencing of circulating tumor cells, isolated by human HLA sorting, to identify altered signaling and metabolic pathways as well as potential therapeutic targets. [Mol Cancer Ther] Abstract

PAWI-2 Overcomes Tumor Stemness and Drug Resistance via Cell Cycle Arrest in Integrin β₃-KRAS-Dependent Pancreatic Cancer Stem Cells

A highly validated CSC model (FGβ₃ cells) was used to test a novel compound to eradicate CSCs. Compared to parental bulk FG cells, PAWI-2 showed greater potency to inhibit cell viability and self-renewal capacity of FGβ₃ cells. [Sci Rep] Full Article

Impact of mRNA-Assessed Molecular Subtype Conversion, Intact and Apoptotic Circulating Tumor Cells on Survival of Metastatic Breast Cancer Patients: Proof of Principle

Scientists determined the influence of mRNA-assessed intrinsic subtype stability comparing primary tumor and metastatic tumor biopsies and circulating tumor cell-based liquid biopsies on progression free survival and overall survival. [Diagnostics (Basel)] Full Article

Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry

The authors investigated the use of a folate receptor-targeted fluorescence molecular probe for in vivo labeling of folate receptor positive circulating tumor cells for diffuse in vivo flow cytometry. [Mol Imaging Biol] Abstract

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CTCF-Mediated Genome Organization and Leukemogenesis

The authors highlight the role of CCCTC-binding factor (CTCF) and its associated protein complexes in three-dimensional genome organization in development and leukemogenesis, as well as the roles of CTCF boundary defined topologically associated domain in transcription regulation. [Leukemia] Abstract

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Neurotrope Announces Strategic Partnership with BryoLogyx for Supply of Synthetic Bryostatin-1 and Continuation of the National Cancer Institute (NCI) Trial for Childhood Leukemia

Neurotrope, Inc. announced its entry into a strategic agreement with BryoLogyx Inc. for the supply of synthetic, GMP-certified Bryostatin-1. [Neurotrope, Inc. (PR Newswire Association LLC.)] Press Release

ERYTECH Provides Update on Phase II Investigator Sponsored Trial of Eryaspase in Second-Line Acute Lymphoblastic Leukemia

ERYTECH Pharma provided an update on the ongoing Phase II trial, sponsored by the Nordic Society of Paediatric Haematology and Oncology of eryaspase in second-line acute lymphoblastic leukemia patients. [ERYTECH Pharma (Globe Newswire, Inc.)] Press Release

As Pandemic Pounds US Universities, Federal Support Helps Their Labs Stay Afloat

This spring, as the coronavirus pandemic shuttered US higher education, many college presidents began to warn of the dire financial impact of a frozen US economy on their institutions. Their mix of revenue sources largely determined how much they might be hurt. [ScienceInsider] Editorial

NIH Grapples with Rush to Claim Billions in Pandemic Research Funds

For the second time in just over 10 years, the National Institutes of Health (NIH) is scrambling to hand out billions of dollars in emergency research funding and scientists are rushing to get a piece of the action—even as some confusion and concerns abound. [ScienceInsider] Editorial

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NEW Postdoctoral Research Fellowship – Cancer Biology (Massachusetts General Hospital)

Faculty and Postdoctoral Positions – Stem Cells and Cancer (Shanghai Jiao Tong University)

PhD Student Position – Leukemic Stem Cell Immune Targeting (Karolinska Institutet)

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope)

Postdoctoral Position – Epigenetic Control of Cancer Stem Cell Biology (University of Freiburg)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Position – Bioinformatics and Computational Biology of Stem Cell and Cancer Epigenetics (Albert Einstein College of Medicine)

Postdoctoral Fellow – Stem Cell and Leukemia Metabolism (Children’s Medical Center Research Institute)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Fellowship – Leukemia Stem Cell Research (Josep Carreras Leukaemia Research Institute)

Scientist – Stem Cells and Cellular Biology (Athersys, Inc.)

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