Cancer Stem Cell News Volume 9.23 | Jun 17 2020

2020-17-06 | CSCN 9.23

Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.23 – 17 June, 2020
TOP STORY

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Researchers showed that genetic depletion and pharmacological inhibition of fat mass and obesity-associated protein dramatically attenuated leukemia stem/initiating cell self-renewal and reprogrammed immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
[Cancer Cell]

AbstractGraphical Abstract

Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
PUBLICATIONSRanked by the impact factor of the journal

Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]

AbstractGraphical Abstract

p53 Destabilizing Protein Skews Asymmetric Division and Enhances NOTCH Activation to Direct Self-Renewal of TICs

Researchers identified TBC1D15-mediated oncogenic mechanisms and tested the tumorigenic roles of TBC1D15 in vivo.
[Nature Communications]

Full Article

Dual Role of WISP1 in Maintaining Glioma Stem Cells and Tumor-Supportive Macrophages in Glioblastoma

Investigators showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]

Full Article

Ibuprofen Mediates Histone Modification to Diminish Cancer Cell Stemness Properties via a COX2-Dependent Manner

The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.
[British Journal of Cancer]

Abstract

Caveolin-1 Inhibits Breast Cancer Stem Cells via c-Myc-Mediated Metabolic Reprogramming

Scientists demonstrated that the downregulation of caveolin-1 usually occurred in breast cancer stem cells and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis.
[Cell Death & Disease]

Full Article

A Positive Feedback Loop between c-Myc Up-Regulation, Glycolytic Shift and Histone Acetylation Enhances Cancer Stem Cell-Like Property and Tumorigenicity of Cr(VI)-Transformed Cells

Researchers investigated the potential role and mechanism of metabolism dysregulation in chronic hexavalent chromium carcinogenesis. It was found that Cr(VI)-transformed cells displayed glycolytic shift, which depends on the up-regulation of c-Myc.
[Toxicological Sciences]

Abstract

MicroRNA-128-3p Enhances the Chemosensitivity of Temozolomide in Glioblastoma by Targeting c-Met and EMT

The effects of miR-128-3p and temozolomide (TMZ) on the proliferation of glioblastoma cells were investigated by cell counting kit-8. Transwell and intracerebral invasion assays were applied to determine the effects of the combination of miR-128-3p and TMZ on the invasion and migration of glioblastoma in vitro and in vivo.
[Scientific Reports]

Full Article

Tocilizumab Potentiates Cisplatin Cytotoxicity and Targets Cancer Stem Cells in Triple‐Negative Breast Cancer

Tocilizumab suppressed the stemness‐related characteristics of triple‐negative breast cancer cells, through the inhibition of the Wnt/β‐catenin breast cancer stem cell‐related pathway.
[Molecular Carcinogenesis]

Abstract

How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
REVIEWS

Cancer Stem Cells in Soft-Tissue Sarcomas

The authors review the published evidence of cancer stem cells (CSCs) in soft tissue sarcoma (STS), discussing the molecular characteristic of CSCs, the commonly used isolation techniques and the new possibilities of targeting CSCs as a way to improve STS treatment and consequently patient outcome.
[Cells]

Full Article

INDUSTRY AND POLICY NEWS

TG Therapeutics Completes Rolling Submission of New Drug Application to the US Food and Drug Administration for Umbralisib as a Treatment for Patients with Previously Treated Marginal Zone Lymphoma or Follicular Lymphoma

TG Therapeutics, Inc. announced the completion of the rolling submission of a New Drug Application (NDA) to the FDA requesting accelerated approval of umbralisib, the company’s investigational once-daily, oral, dual inhibitor of PI3K-delta and CK1-epsilon, as a treatment for patients with previously treated marginal zone lymphoma and follicular lymphoma.
[TG Therapeutics]

Press Release

PharmaCyte Biotech Successfully Accelerates Development of Container Closure Integrity Test for Pancreatic Cancer Clinical Trial Product

PharmaCyte Biotech, Inc. announced that it has successfully accelerated the development of its Container Closure Integrity test– an essential component of the Stability Test required by the FDA.
[PharmaCyte Biotech Inc.]

Press Release

Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]

Editorial

FEATURED EVENT

Keystone eSymposia | Advances in Cancer Immunotherapy

2020-08-17 – 2020-08-19
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Research Fellowship – Cancer Biology

Massachusetts General Hospital – Charlestown, Massachusetts, United States

Faculty and Postdoctoral Positions – Stem Cells and Cancer

Shanghai Jiao Tong University – Shanghai, China

PhD Student Position – Leukemic Stem Cell Immune Targeting

Karolinska Institutet – Stockholm, Sweden

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics

City of Hope – Monrovia, California, United States

Postdoctoral Position – Epigenetic Control of Cancer Stem Cell Biology

University of Freiburg – Freiburg, Germany

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

The University of Texas Southwestern Medical Center – Dallas, Texas, United States

Postdoctoral Position – Bioinformatics and Computational Biology of Stem Cell and Cancer Epigenetics

Albert Einstein College of Medicine – New York, New York, United States

Postdoctoral Fellow – Stem Cell and Leukemia Metabolism

Children’s Medical Center Research Institute – Dallas, Texas, United States

Assistant Professor – Cell Cycle and Cancer Biology

Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

Postdoctoral Fellowship – Leukemia Stem Cell Research

Josep Carreras Leukaemia Research Institute – Barcelona, Spain

> See All Jobs

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