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| Vol. 9.23 – 17 June, 2020 |
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Researchers showed that genetic depletion and pharmacological inhibition of fat mass and obesity-associated protein dramatically attenuated leukemia stem/initiating cell self-renewal and reprogrammed immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
[Cancer Cell]
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| PUBLICATIONSRanked by the impact factor of the journal |
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Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]
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Researchers identified TBC1D15-mediated oncogenic mechanisms and tested the tumorigenic roles of TBC1D15 in vivo.
[Nature Communications]
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Investigators showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]
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The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.
[British Journal of Cancer]
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Scientists demonstrated that the downregulation of caveolin-1 usually occurred in breast cancer stem cells and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis.
[Cell Death & Disease]
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Researchers investigated the potential role and mechanism of metabolism dysregulation in chronic hexavalent chromium carcinogenesis. It was found that Cr(VI)-transformed cells displayed glycolytic shift, which depends on the up-regulation of c-Myc.
[Toxicological Sciences]
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The effects of miR-128-3p and temozolomide (TMZ) on the proliferation of glioblastoma cells were investigated by cell counting kit-8. Transwell and intracerebral invasion assays were applied to determine the effects of the combination of miR-128-3p and TMZ on the invasion and migration of glioblastoma in vitro and in vivo.
[Scientific Reports]
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Tocilizumab suppressed the stemness‐related characteristics of triple‐negative breast cancer cells, through the inhibition of the Wnt/β‐catenin breast cancer stem cell‐related pathway.
[Molecular Carcinogenesis]
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The authors review the published evidence of cancer stem cells (CSCs) in soft tissue sarcoma (STS), discussing the molecular characteristic of CSCs, the commonly used isolation techniques and the new possibilities of targeting CSCs as a way to improve STS treatment and consequently patient outcome.
[Cells]
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TG Therapeutics, Inc. announced the completion of the rolling submission of a New Drug Application (NDA) to the FDA requesting accelerated approval of umbralisib, the company’s investigational once-daily, oral, dual inhibitor of PI3K-delta and CK1-epsilon, as a treatment for patients with previously treated marginal zone lymphoma and follicular lymphoma.
[TG Therapeutics]
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PharmaCyte Biotech, Inc. announced that it has successfully accelerated the development of its Container Closure Integrity test– an essential component of the Stability Test required by the FDA.
[PharmaCyte Biotech Inc.]
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The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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2020-08-17 – 2020-08-19
Virtual
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| Massachusetts General Hospital – Charlestown, Massachusetts, United States
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| Shanghai Jiao Tong University – Shanghai, China
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| Karolinska Institutet – Stockholm, Sweden
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| City of Hope – Monrovia, California, United States
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| University of Freiburg – Freiburg, Germany
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States
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| Albert Einstein College of Medicine – New York, New York, United States
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| Children’s Medical Center Research Institute – Dallas, Texas, United States
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States
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| Josep Carreras Leukaemia Research Institute – Barcelona, Spain
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