Cancer Stem Cell News Volume 9.24 | Jun 24 2020


    2020-24-06 | CSCN 9.24

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.24 – 24 June, 2020

    Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

    Scientists report that a positive modulator of canonical WNT signaling pathway, RSPO-LGR4, upregulated key self-renewal genes and is essential for leukemia stem cell self-renewal in a subset of acute myeloid leukemia.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Quantitative Proteomics Reveals Specific Metabolic Features of Acute Myeloid Leukemia Stem Cells

    By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlighted novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs.


    Chronic Circadian Disruption Modulates Breast Cancer Stemness and Immune Microenvironment to Drive Metastasis in Mice

    Investigators observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment.
    [Nature Communications]

    Full Article

    A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior

    Scientists report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer.
    [Nature Communications]

    Full Article

    ARS2/MAGL Signaling in Glioblastoma Stem Cells Promotes Self-Renewal and M2-Like Polarization of Tumor-Associated Macrophages

    Investigators demonstrated that arsenite-resistance protein 2 (ARS2), a zinc finger protein that is essential for early mammalian development, played critical roles in glioblastoma stem cell maintenance and M2-like tumor-associated macrophage polarization.
    [Nature Communications]

    Full Article

    Isoprenylcysteine Carboxylmethyltransferase Is Required for the Impact of Mutant KRAS on TAZ Protein Level and Cancer Cell Self-Renewal

    The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells.

    Full Article

    Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

    From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
    [British Journal of Cancer]


    Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling

    Caudatin inhibited breast cancer cell proliferation, mammosphere formation and tumor growth. Caudatin decreased the CD44+/CD24 and aldehyde dehydrogenase positive cell proportions and the levels of c-Myc, Oct4, Sox2, and CD44.

    Full Article

    Molecular Characterization of Circulating Tumor Cells Identifies Predictive Markers for Outcome in Primary, Triple‐Negative Breast Cancer Patients

    mRNA profiles of circulating tumor cells were analyzed in patients with triple‐negative breast cancer before and after therapy to identify additional treatment options.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

    Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse induced pluripotent stem cells (iPSCs) into CSCs in the tumor microenvironment.
    [Scientific Reports]

    Full Article

    Watch 'collaborating to accelerate COVID-19 research'

    Radiotherapy Targeting Cancer Stem Cells “Awakens” Them to Induce Tumor Relapse and Metastasis in Oral Cancer

    Researchers summarize methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation to highlight their response to radiotherapy and potential role in tumor recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs.
    [International Journal of Oral Science]

    Full Article

    Prognostic Value of Circulating Tumor Cells Detected with the CellSearch System in Esophageal Cancer Patients: A Systematic Review and Meta-Analysis

    The authors demonstrated that circulating tumor cells positivity determined by the CellSearch system were correlated with the prognosis of esophageal carcinoma (EC) patients and might indicate a poor therapeutic response to chemotherapy in EC patients.
    [BMC Cancer]

    Full Article


    Marker Therapeutics Receives USAN Approval for "Zelenoleucel" as Nonproprietary Name for MT-401, Multi-Tumor-Associated Antigen Targeted T Cell Product for Acute Myeloid Leukemia

    Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings.
    [Marker Therapeutics, Inc.]

    Press Release

    PharmaCyte Biotech Provides IND Submission Update for Pancreatic Cancer Clinical Trial

    PharmaCyte Biotech, Inc. announced that it is closing the gap in completing its Investigational New Drug application (IND) for its planned clinical trial in locally advanced, inoperable, pancreatic cancer.
    [PharmaCyte Biotech Inc.]

    Press Release

    Trump to Suspend New Visas for Foreign Scholars

    With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
    [Nature News]


    Virtual Lab Tours for Recruitment and Outreach

    Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
    [The Scientist]



    The New York Stem Cell Foundation (NYSCF) Conference

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    Lund University – Lund, Sweden

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    Massachusetts General Hospital – Charlestown, Massachusetts, United States

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    Shanghai Jiao Tong University – Shanghai, China

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    City of Hope – Monrovia, California, United States

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    University of Freiburg – Freiburg, Germany

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