| Vol. 9.24 – 24 June, 2020 |
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| Scientists report that a positive modulator of canonical WNT signaling pathway, RSPO-LGR4, upregulated key self-renewal genes and is essential for leukemia stem cell self-renewal in a subset of acute myeloid leukemia. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlighted novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs. [Blood] |
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| Investigators observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment. [Nature Communications] |
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| Scientists report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer. [Nature Communications] |
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| Investigators demonstrated that arsenite-resistance protein 2 (ARS2), a zinc finger protein that is essential for early mammalian development, played critical roles in glioblastoma stem cell maintenance and M2-like tumor-associated macrophage polarization. [Nature Communications] |
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| The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells. [Oncogene] |
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| From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed. [British Journal of Cancer] |
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| Caudatin inhibited breast cancer cell proliferation, mammosphere formation and tumor growth. Caudatin decreased the CD44+/CD24− and aldehyde dehydrogenase positive cell proportions and the levels of c-Myc, Oct4, Sox2, and CD44. [Biomolecules] |
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| mRNA profiles of circulating tumor cells were analyzed in patients with triple‐negative breast cancer before and after therapy to identify additional treatment options. [Journal of Cellular and Molecular Medicine] |
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| Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse induced pluripotent stem cells (iPSCs) into CSCs in the tumor microenvironment. [Scientific Reports] |
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| Researchers summarize methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation to highlight their response to radiotherapy and potential role in tumor recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs. [International Journal of Oral Science] |
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| The authors demonstrated that circulating tumor cells positivity determined by the CellSearch system were correlated with the prognosis of esophageal carcinoma (EC) patients and might indicate a poor therapeutic response to chemotherapy in EC patients. [BMC Cancer] |
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| Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings. [Marker Therapeutics, Inc.] |
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| PharmaCyte Biotech, Inc. announced that it is closing the gap in completing its Investigational New Drug application (IND) for its planned clinical trial in locally advanced, inoperable, pancreatic cancer. [PharmaCyte Biotech Inc.] |
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| With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science. [Nature News] |
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| Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online. [The Scientist] |
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| 2020-10-20 – 2020-10-21 Virtual |
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| Lund University – Lund, Sweden |
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| Massachusetts General Hospital – Charlestown, Massachusetts, United States |
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| Shanghai Jiao Tong University – Shanghai, China |
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| City of Hope – Monrovia, California, United States |
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| University of Freiburg – Freiburg, Germany |
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