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Vol. 9.26 – 15 July, 2020
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Using the circulating tumor cell (CTC)-iChip to purify CTCs from pancreatic ductal adenocarcinoma patients for RNA-seq characterization, scientists identified three major correlated gene sets, with stemness genes LIN28B/KLF4, WNT5A, and LGALS3 enriched in each correlated gene set; only LIN28B CTC expression was prognostic.
[Nature Communications]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow.
[Oncogene]
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To study the interplay between senescence, stemness, and cancer, the authors applied a stem cell medium to human embryonic fibroblasts and cancer cell lines.
[Cancers]
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Researchers revealed that lncRNA HOTAIR could increase prostatic cancer stem-like cells population via activating STAT3 signaling.
[Aging]
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The authors investigated the consensus of leukemia inhibitory factor (LIF) and LIF receptor immunization on the growth of mouse mammary tumors.
[Scientific Reports]
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Researchers investigated two methods for in vitro cultivation of putative prostate cancer stem cells based on ‘high-salt agar’ and ‘monoclonal cultivation’.
[Scientific Reports]
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The authors report that chemosensitivity assays using liquid biopsy-derived metastatic epithelial ovarian cancer circulating tumor cells, from ten patients, nine with stage IIIC and one with stage IV disease, in progression after systemic chemotherapy, submitted for hypoxic isolated abdominal perfusion, were both feasible and useful in predicting response to therapy.
[International Journal of Molecular Sciences]
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Investigators evaluated the clinical properties of different phenotypic circulating tumor cells in patients with non-small cell lung cancer.
[Journal of Cancer Research and Clinical Oncology]
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Functional inhibition of PKCλ through siRNA-mediated knockdown or CRISPR-Cas9-mediated knockout in ALDH1high MDA-MB 157 and MDA-MB 468 basal-like breast cancer cells led to increases in the numbers of trypan blue-positive and active-caspase 3-positive cells, as well as suppression of tumor-sphere formation and cell migration.
[PLoS One]
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Researchers utilized both SNP array and gene expression profiling to better understand glioblastoma stem-like cells and their relation to malignant disease.
[PLoS One]
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Tobacco smoke was found to play a role in accelerating the cell growth transition from G1 to S phase in renal cancer stem cells.
[Environmental Toxicology]
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Scientists provide a new in vitro long‐term culture model for a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
[FEBS Open Bio]
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Researchers address the current knowledge regarding CSCs with a focus on designing chemotherapeutic and bio-imaging reagents that target CSCs.
[Chemical Society Reviews]
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Invivoscribe’s therapeutics division announced that the company has in-licensed technology involving a preclinical molecule and associated small molecules from Domainex Ltd.
[Invivoscribe, Inc.]
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To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider]
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September 30 – October 3
Virtual
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Karolinska Institutet – Huddinge, Sweden
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Lund University – Lund, Sweden
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Massachusetts General Hospital – Charlestown, Massachusetts, United States
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Shanghai Jiao Tong University – Shanghai, China
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City of Hope – Monrovia, California, United States
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Cancer Stem Cell News
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