Cancer Stem Cell News Volume 9.26 | Jul 15 2020

2020-07-15 | CSCN 9.26

Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.26 – 15 July, 2020

Pancreatic Circulating Tumor Cell Profiling Identifies LIN28B as a Metastasis Driver and Drug Target

Using the circulating tumor cell (CTC)-iChip to purify CTCs from pancreatic ductal adenocarcinoma patients for RNA-seq characterization, scientists identified three major correlated gene sets, with stemness genes LIN28B/KLF4, WNT5A, and LGALS3 enriched in each correlated gene set; only LIN28B CTC expression was prognostic.
[Nature Communications]

Full Article

How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
PUBLICATIONSRanked by the impact factor of the journal

Signal-Transducing Adapter Protein-1 Is Required for Maintenance of Leukemic Stem Cells in CML

Investigators found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow.

Full Article

Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts

To study the interplay between senescence, stemness, and cancer, the authors applied a stem cell medium to human embryonic fibroblasts and cancer cell lines.

Full Article

HOTAIR Expands the Population of Prostatic Cancer Stem-Like Cells and Causes Docetaxel Resistance via Activating STAT3 Signaling

Researchers revealed that lncRNA HOTAIR could increase prostatic cancer stem-like cells population via activating STAT3 signaling.

Full Article

Immunization against Leukemia Inhibitory Factor and Its Receptor Suppresses Tumor Formation of Breast Cancer Initiating Cells in BALB/c Mouse

The authors investigated the consensus of leukemia inhibitory factor (LIF) and LIF receptor immunization on the growth of mouse mammary tumors.
[Scientific Reports]

Full Article

Prostate Cancer-Derived Holoclones: A Novel and Effective Model for Evaluating Cancer Stemness

Researchers investigated two methods for in vitro cultivation of putative prostate cancer stem cells based on ‘high-salt agar’ and ‘monoclonal cultivation’.
[Scientific Reports]

Full Article

A Pilot Study of the Predictive Potential of Chemosensitivity and Gene Expression Assays Using Circulating Tumor Cells from Patients with Recurrent Ovarian Cancer

The authors report that chemosensitivity assays using liquid biopsy-derived metastatic epithelial ovarian cancer circulating tumor cells, from ten patients, nine with stage IIIC and one with stage IV disease, in progression after systemic chemotherapy, submitted for hypoxic isolated abdominal perfusion, were both feasible and useful in predicting response to therapy.
[International Journal of Molecular Sciences]

Full Article

Correlations between Circulating Tumor Cell Phenotyping and 18F-Fluorodeoxyglucose Positron Emission Tomography Uptake in Non-Small Cell Lung Cancer

Investigators evaluated the clinical properties of different phenotypic circulating tumor cells in patients with non-small cell lung cancer.
[Journal of Cancer Research and Clinical Oncology]


High PKCλ Expression Is Required for ALDH1-Positive Cancer Stem Cell Function and Indicates a Poor Clinical Outcome in Late-Stage Breast Cancer Patients

Functional inhibition of PKCλ through siRNA-mediated knockdown or CRISPR-Cas9-mediated knockout in ALDH1high MDA-MB 157 and MDA-MB 468 basal-like breast cancer cells led to increases in the numbers of trypan blue-positive and active-caspase 3-positive cells, as well as suppression of tumor-sphere formation and cell migration.
[PLoS One]

Full Article

Molecular Analyses of Glioblastoma Stem-Like Cells and Glioblastoma Tissue

Researchers utilized both SNP array and gene expression profiling to better understand glioblastoma stem-like cells and their relation to malignant disease.
[PLoS One]

Full Article

Nanog Mediates Tobacco Smoke‐Induced Enhancement of Renal Cancer Stem Cell Properties

Tobacco smoke was found to play a role in accelerating the cell growth transition from G1 to S phase in renal cancer stem cells.
[Environmental Toxicology]


A New Protocol for Long‐Term Culture of a Specific Subpopulation of Liver Cancer Stem Cells Enriched by Cell Surface Markers

Scientists provide a new in vitro long‐term culture model for a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
[FEBS Open Bio]

Full Article

Watch 'collaborating to accelerate COVID-19 research'

Cancer Stem Cell-Targeted Bio-Imaging and Chemotherapeutic Perspective

Researchers address the current knowledge regarding CSCs with a focus on designing chemotherapeutic and bio-imaging reagents that target CSCs.
[Chemical Society Reviews]



Invivoscribe Launches New Division for Drug Development. Licenses Small Molecule Inhibitors from Domainex to Treat Acute Myeloid Leukemia

Invivoscribe’s therapeutics division announced that the company has in-licensed technology involving a preclinical molecule and associated small molecules from Domainex Ltd.
[Invivoscribe, Inc.]

Press Release

Journals Endorse New Checklist to Clean Up Sloppy Animal Research

To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider]



53rd Annual Meeting Society for Leukocyte Biology

September 30 – October 3

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Doctoral Student Position – Epigenetic and Transcriptional Regulation of Acute Myeloid Leukemia

Karolinska Institutet – Huddinge, Sweden

Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

Lund University – Lund, Sweden

Postdoctoral Research Fellowship – Cancer Biology

Massachusetts General Hospital – Charlestown, Massachusetts, United States

Faculty and Postdoctoral Positions – Stem Cells and Cancer

Shanghai Jiao Tong University – Shanghai, China

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics

City of Hope – Monrovia, California, United States

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