 | | Vol. 9.28 – 29 July, 2020 |
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| The authors investigated spheroid-forming cells in a metastatic triple-negative breast cancer model. This strategy enabled them to specifically study a population of long-lived tumor cells enriched in cancer stem-like cells, which showed stem-like characteristics and induced metastases.
[Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using an engineered medium that enhanced the ratio of CSCs in HCT116 cell cultures, researchers demonstrated by clonogenicity tests and in sphere assays that Salinomycin acted mainly on CSCs, while SN38 acted mainly on proliferating cancer cells.
[Journal of Controlled Release] |
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| Using mouse tumor models, the authors showed that macrophage-derived soluble glycoprotein nonmetastatic B (GPNMB) increased tumor growth and metastasis in Gpnmb-mutant mice.
[Cellular & Molecular Immunology] |
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| The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease] |
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| Researchers evaluated the biological function of a new microenvironment-regulated long non-coding RNA, lncMat2B, in breast cancer. In multicellular tumor spheroids, the expression of lncMat2B presented an increase and a zonal heterogeneity, as it was expressed principally in quiescent cells of hypoxic regions of the multicellular tumor spheroids.
[Carcinogenesis] |
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| Chondrosarcoma cells were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. The effects of treatment on cancer stem cells, stemness-associated phenotype, radioresistance and tumor-initiating properties were evaluated.
[Radiotherapy and Oncology] |
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| Investigators found that Bruton’s tyrosine kinase was highly expressed in primary neuroblastoma samples, preferentially in MYCN-amplified neuroblastoma cases, and was associated with a poor prognosis.
[Cellular Oncology] |
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| Scientists investigated the role of miR‐124 in nasopharyngeal carcinoma (NPC) CSCs. qRT‐PCR was performed to measure miR‐124 expression in NPC tissues and cell lines and the effects of miR‐124 on stem‐like properties and radiosensitivity of NPC cells measured.
[Journal of Cellular and Molecular Medicine] |
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| The authors reconstituted PTEN-deficient breast cancer cells with wild-type and mutant PTEN, demonstrating that restoration of PTEN expression converted cancer cells with mesenchymal traits to an epithelial phenotype and inhibited cancer stem cell activity.
[Scientific Reports] |
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| Researchers investigated the uptake behavior of various polymethine dyes on leukemia cell lines and searched for carrier proteins that guide dye transport using RNA interference.
[Molecular Therapy-Oncolytics] |
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| The authors introduce SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. They next discuss its role in embryonic development and stem cell-renewal.
[Signal Transduction and Targeted Therapy] |
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| Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery] |
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| Several Canadian-made cell therapies will take a major step closer to the clinic thanks to a new collaboration between the Ontario Institute for Regenerative Medicine and the Centre for Commercialization of Cancer Immunotherapy and Regenerative Medicine.
[Ontario Institute for Regenerative Medicine] |
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| Cleave Therapeutics, Inc. announced that the first patient has been dosed with CB-5339 in a Phase I clinical trial of patients with relapsed/refractory AML or relapsed/refractory intermediate or high-risk MDS.
[Cleave Therapeutics, Inc.] |
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| September 10 – September 11
Virtual |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | West Virginia University – Morgantown, West Virginia, United States |
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| | Lund University – Lund, Sweden |
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| | Massachusetts General Hospital – Charlestown, Massachusetts, United States |
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| | Shanghai Jiao Tong University – Shanghai, China |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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