Cancer Stem Cell News Volume 9.28 | Jul 29 2020


    2020-07-29 | CSCN 9.28

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.28 – 29 July, 2020

    Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem-Like Cells and Reduces Metastases through Effects on Lipid Anabolism

    The authors investigated spheroid-forming cells in a metastatic triple-negative breast cancer model. This strategy enabled them to specifically study a population of long-lived tumor cells enriched in cancer stem-like cells, which showed stem-like characteristics and induced metastases.
    [Cancer Research]


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    Combined Nanomedicines Targeting Colorectal Cancer Stem Cells and Cancer Cells

    Using an engineered medium that enhanced the ratio of CSCs in HCT116 cell cultures, researchers demonstrated by clonogenicity tests and in sphere assays that Salinomycin acted mainly on CSCs, while SN38 acted mainly on proliferating cancer cells.
    [Journal of Controlled Release]

    AbstractGraphical Abstract

    The Soluble Glycoprotein NMB (GPNMB) Produced by Macrophages Induces Cancer Stemness and Metastasis via CD44 and IL-33

    Using mouse tumor models, the authors showed that macrophage-derived soluble glycoprotein nonmetastatic B (GPNMB) increased tumor growth and metastasis in Gpnmb-mutant mice.
    [Cellular & Molecular Immunology]


    miR-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

    The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
    [Cell Death & Disease]

    Full Article

    LncMat2B Regulated by Severe Hypoxia Induces Cisplatin Resistance by Increasing DNA Damage Repair and Tumor-Initiating Population in Breast Cancer Cells

    Researchers evaluated the biological function of a new microenvironment-regulated long non-coding RNA, lncMat2B, in breast cancer. In multicellular tumor spheroids, the expression of lncMat2B presented an increase and a zonal heterogeneity, as it was expressed principally in quiescent cells of hypoxic regions of the multicellular tumor spheroids.


    A Multimodal Treatment of Carbon Ions Irradiation, miRNA-34 and mTOR Inhibitor Specifically Control High-Grade Chondrosarcoma Cancer Stem Cells

    Chondrosarcoma cells were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. The effects of treatment on cancer stem cells, stemness-associated phenotype, radioresistance and tumor-initiating properties were evaluated.
    [Radiotherapy and Oncology]


    Aberrantly Expressed Bruton’s Tyrosine Kinase Preferentially Drives Metastatic and Stem Cell-Like Phenotypes in Neuroblastoma Cells

    Investigators found that Bruton’s tyrosine kinase was highly expressed in primary neuroblastoma samples, preferentially in MYCN-amplified neuroblastoma cases, and was associated with a poor prognosis.
    [Cellular Oncology]


    MicroRNA‐124 Inhibits Stem‐Like Properties and Enhances Radiosensitivity in Nasopharyngeal Carcinoma Cells via Direct Repression of Expression of JAMA

    Scientists investigated the role of miR‐124 in nasopharyngeal carcinoma (NPC) CSCs. qRT‐PCR was performed to measure miR‐124 expression in NPC tissues and cell lines and the effects of miR‐124 on stem‐like properties and radiosensitivity of NPC cells measured.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    PTEN Suppresses Epithelial–Mesenchymal Transition and Cancer Stem Cell Activity by Downregulating Abi1

    The authors reconstituted PTEN-deficient breast cancer cells with wild-type and mutant PTEN, demonstrating that restoration of PTEN expression converted cancer cells with mesenchymal traits to an epithelial phenotype and inhibited cancer stem cell activity.
    [Scientific Reports]

    Full Article

    Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

    Researchers investigated the uptake behavior of various polymethine dyes on leukemia cell lines and searched for carrier proteins that guide dye transport using RNA interference.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

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    Functional Characterization of SOX2 as an Anticancer Target

    The authors introduce SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. They next discuss its role in embryonic development and stem cell-renewal.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Emerging Role of FBXO22 in Carcinogenesis

    Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and highlight the alteration of FBXO22 expression in a variety of human malignancies.
    [Cell Death Discovery]

    Full Article


    Strategic Alliance a Shot in the Arm for Stem Cell Commercialization Efforts

    Several Canadian-made cell therapies will take a major step closer to the clinic thanks to a new collaboration between the Ontario Institute for Regenerative Medicine and the Centre for Commercialization of Cancer Immunotherapy and Regenerative Medicine.
    [Ontario Institute for Regenerative Medicine]

    Press Release

    Cleave Therapeutics Announces Commencement of a Phase I Clinical Study of CB-5339, A Valosin-Containing Protein (VCP)/p97 Inhibitor, in Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

    Cleave Therapeutics, Inc. announced that the first patient has been dosed with CB-5339 in a Phase I clinical trial of patients with relapsed/refractory AML or relapsed/refractory intermediate or high-risk MDS.
    [Cleave Therapeutics, Inc.]

    Press Release


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