Cancer Stem Cell News Volume 9.29 | Aug 5 2020


    2020-08-05 | CSCN 9.29

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.29 – 5 August, 2020

    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

    The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
    PUBLICATIONSRanked by the impact factor of the journal

    DOCK6 Promotes Chemo- and Radioresistance of Gastric Cancer by Modulating WNT/β-Catenin Signaling and Cancer Stem Cell Traits

    The authors identified DOCK6, a guanine nucleotide exchange factor for Rac1 and CDC42, as an independent biomarker for gastric cancer prognosis. Clinical findings indicate the positive correlation of higher DOCK6 expression with tumor size, depth of invasion, lymph node metastasis, vascular invasion, and pathological stage.


    Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

    Smurf1 promoted cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.


    Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

    Investigators developed a therapeutic single-chain variable-fragment antibody that recognised the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
    [British Journal of Cancer]


    AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

    Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.

    Full Article

    Interplay between V-ATPase G1 and Small EV-miRNAs Modulates ERK1/2 Activation in GBM Stem Cells and Non-Neoplastic Milieu

    The authors investigated the role of V1G1 in glioma stem cell small extracellular vesicles and their effects on primary brain cultures.
    [Molecular Cancer Research]


    Roniciclib Down-Regulates Stemness and Inhibits Cell Growth by Inducing Nucleolar Stress in Neuroblastoma

    Scientists found that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
    [Scientific Reports]

    Full Article

    Regulating Stem Cell-Related Genes Induces the Plastic Differentiation of Cancer Stem Cells to Treat Breast Cancer

    Investigators propose a plastic differentiation strategy for irreversible differentiation of cancer stem cells, and salinomycin and its newly constructed functional liposomes were used to implement this strategy.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

    Polydatin Executes Anticancer Effects against Glioblastoma Multiforme by Inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail Signaling Pathway

    Scientists demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
    [Life Sciences]


    Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.

    Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

    The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.

    Full Article


    Britta Will, Ph.D., Wins Pershing Square Sohn Prize for Cancer Research

    Britta Will, Ph.D., assistant professor of medicine and of cell biology at Albert Einstein College of Medicine, has won a 2020 Pershing Square Sohn Prize for Young Investigators in Cancer Research. Dr. Will is one of seven New York City area-based scientists to receive the prestigious award, which provides $600,000 over three years for innovative basic science cancer research.
    [Albert Einstein College of Medicine]

    Press Release

    Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics’ First-In-Class EGFR Dual-Targeting CAR for NK Cell Treatment of Glioblastoma & Other Solid Tumors

    Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
    [Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]

    Press Release


    Cancer Stem Cells: Advances in Biology and Clinical Translation

    May 18 – May 21, 2021
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    Faculty Position – Prostate Cancer Biology and Cancer Epigenetics

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Research Fellow – Hematopoiesis, Marrow Failure and Myeloid Leukemia

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    Postdoctoral Research Fellowship – Cancer Biology

    Massachusetts General Hospital – Charlestown, Massachusetts, United States

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