 | | Vol. 9.29 – 5 August, 2020 |
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| The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified DOCK6, a guanine nucleotide exchange factor for Rac1 and CDC42, as an independent biomarker for gastric cancer prognosis. Clinical findings indicate the positive correlation of higher DOCK6 expression with tumor size, depth of invasion, lymph node metastasis, vascular invasion, and pathological stage.
[Oncogene] |
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| Smurf1 promoted cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene] |
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| Investigators developed a therapeutic single-chain variable-fragment antibody that recognised the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer] |
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| Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
[Oncogenesis] |
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| The authors investigated the role of V1G1 in glioma stem cell small extracellular vesicles and their effects on primary brain cultures.
[Molecular Cancer Research] |
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| Scientists found that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
[Scientific Reports] |
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| Investigators propose a plastic differentiation strategy for irreversible differentiation of cancer stem cells, and salinomycin and its newly constructed functional liposomes were used to implement this strategy.
[Molecular Therapy-Oncolytics] |
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| Scientists demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
[Life Sciences] |
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| The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.
[Cancers] |
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| Britta Will, Ph.D., assistant professor of medicine and of cell biology at Albert Einstein College of Medicine, has won a 2020 Pershing Square Sohn Prize for Young Investigators in Cancer Research. Dr. Will is one of seven New York City area-based scientists to receive the prestigious award, which provides $600,000 over three years for innovative basic science cancer research.
[Albert Einstein College of Medicine] |
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| Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)] |
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| May 18 – May 21, 2021
Hannover, Germany |
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| | Northwestern University – Chicago, Illinois, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | West Virginia University – Morgantown, West Virginia, United States |
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| | Massachusetts General Hospital – Charlestown, Massachusetts, United States |
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