Cancer Stem Cell News Volume 9.33 | Sep 2 2020

2020-09-02 | CSCN 9.33

Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.33 – 2 September, 2020

Wnt Activation as a Therapeutic Strategy in Medulloblastoma

By using primary patient-derived medulloblastoma (MB) brain tumor-initiating cell lines, investigators characterized differences in the tumor-initiating capacity of Wnt, group three, and group four MB.
[Nature Communications]

AbstractPress Release

Resources for Your T Cell Therapy Research
PUBLICATIONSRanked by the impact factor of the journal

Model of Patients with Liver Cancer Based on Tumor Stem Cell Content and Immune Process

Scientists used RNA-seq and clinical data of liver hepatocellular carcinoma from The Cancer Genome Atlas, Estimation of Stromal and Immune cells in Malignant Tumours, mRNA stemness index score, and weighted gene correlation network analysis methods to find genes significantly linked to the degree of immune infiltration and content of tumor stem cells.

Full Article

Poor Proteasomal Function with Radioiodine Eliminates CT26 Colon Cancer Stem Cells Resistant to Bortezomib Therapy

Tumor response to conventional bortezomib treatment was enhanced by targeted radiotherapy of resistant cancer stem cells that had characteristically poor proteasome function.
[Scientific Reports]

Full Article

Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers

Researchers found the existence of individual differences in the regional distribution of monocarboxylate transporters 1 and 4 and suggested that both transporters had distinct connections to glioblastoma multiforme progression processes.
[International Journal of Molecular Sciences]

Full Article

Lymph Liquid Biopsy for Detection of Cancer Stem Cells

Scientists introduced lymph liquid biopsy through collection of peripheral and central lymph samples and demonstrated its feasibility for detection of stem‐like circulating tumor cells potentially responsible for metastasis development and tumor relapse.
[Cytometry Part A]


Promotes Self-Renewal of Gastric Cancer Cells by Inhibiting Expression of L-PTGDS and PTGDR2

Researchers revealed a novel function of Yes-associated protein 1 (YAP) and the mechanism underlying cancer stem cell regulation by YAP.
[International Journal of Clinical Oncology]


and Gene Mutation Verification of Circulating Tumor Cells of Lung Cancer with Epidermal Growth Factor Receptor Peptide Lipid Magnetic Spheres

Investigators identified an efficient, simple, and specific method of detecting mutations in the epidermal growth factor receptor gene in isolated lung cancer circulating tumor cells and to improve the ability to obtain tumor tissue clinically.
[Thoracic Cancer]

Full Article

of Akt Phosphorylation Is a Key to Targeting Cancer Stem-Like Cells by mTOR Inhibition

Scientists established a CD133+ cell-rich subline from Capan-1 pancreatic cancer cells as a pancreatic cancer stem cell model and compared the effects of KU-0063794, a dual mTORC1/mTORC2 inhibitor, against those of mTORC1-specific rapamycin.
[Human Cell]


the Colon Cancer Cells Sensitivity toward Radiation Therapy via Application of Oct4–Sox2 Complex Decoy Oligodeoxynucleotides

Cellular uptake and localization assays demonstrated that decoy Oct4–Sox2 complex decoy oligodeoxynucleotides could efficiently be transfected to the cells and resided in the subcellular compartment, where they posed their action on gene regulation.
[Molecular Biology Reports]


How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU

The Potential Role of YAP in Head and Neck Squamous Cell Carcinoma

The authors discuss the causes and functional consequences of YAP dysregulation in head and neck squamous cell carcinoma (HNSCC). They also address interactions between YAP and other oncogenic drivers of HNSCC.
[Experimental and Molecular Medicine]

Full Article

Vitamin D Effects on Cell Differentiation and Stemness in Cancer

Scientists revise the current knowledge of the molecular and genetic basis of the regulation by 1,25(OH)2D3 of the differentiation and stemness of human carcinoma cells, cancer-associated fibroblasts and cancer stem cells.

Full Article

Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review

The authors illustrate the mechanism by which OCT4 plays a role in cancer stem cells from the perspective of genetic modification of OCT4, non-coding RNA, complexes and signaling pathways associated with OCT4.
[International Journal of Stem Cells]

Full Article


Food and Drug Administration Approves Onureg® (Azacitidine Tablets), a New Oral Therapy, as Continued Treatment for Adults in First Remission with Acute Myeloid Leukemia

The FDA has approved Onureg® for the continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or CR with incomplete blood count recovery following intensive induction chemotherapy and who was not able to complete intensive curative therapy.
[Bristol Myers Squibb]

Press Release


From Stem Cells to Human Development

September 8 – 11

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Postdoctoral Fellow – Immunology, Genetics, Precision Medicine

St. Anna Children’s Cancer Research Institute – Vienna, Austria

Postdoctoral Associate – RNA Epigenetics in Cancer Stem Cells

Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States

Faculty Position – Prostate Cancer Biology and Cancer Epigenetics

Northwestern University – Chicago, Illinois, United States

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

The University of Texas Southwestern Medical Center – Dallas, Texas, United States

Postdoctoral Research Fellow – Hematopoiesis, Marrow Failure and Myeloid Leukemia

Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

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