| Vol. 9.40 – 21 October, 2020 |
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| Investigators showed that WNT11-FZD7-DAAM1 activated Rho-ROCK1/2-Myosin II and played a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers describe a 2D in vitro system for long-term enrichment of pancreatic CSCs that was amenable to biological and CSC-specific studies. [Nature Communications] |
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| The authors found that ultrasmall Pt(II) dot active targeting nanoparticles displayed a superior DNA damage capability via enhanced-interactions with DNA and a significantly stronger effect in reducing CSC-like property of triple negative breast cancer cells, compared to conventional cisplatin and miriplatin. [Journal of Controlled Release] |
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| Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells. [Oncogene] |
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| Investigators found in breast tumors that the expression of SMAR1 was decreased in CSCs through the cooperative interaction of the pluripotency factors Oct4 and Sox2 with the histone deacetylase HDAC1. [Science SIgnaling] |
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| TRIM28 high level related to higher melanoma stemness as measured with several distinct scores and TRIM28HIGH-expressing melanoma cell lines possess the greater potential of melanosphere formation. [Cancers] |
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| Researchers crossed the MMTV‐PyMT model of mammary gland tumourigenesis with a TgfbiΔ/Δ mouse, and studied the CSC content of the tumors. We performed RNAseq on wt and ko tumours, and analysed the tumour vasculature and the immune compartment by IHC and FACS. [Molecular Oncology] |
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| Several in vitro and in vivo mechanisms involved in pancreatic cancer (PDAC) metastases were investigated following treatment with P-AscH−. Serum from PDAC patients in clinical trials with P-AscH− were tested for the presence and quantity of circulating tumor cell-derived nucleases. [Scientific Reports] |
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| Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133−/CD44−, and CD133+/CD44+ colon cancer cells in vitro. [Journal of Cellular Physiology] |
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| Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across triple negative breast cancer subtypes, prompting the implementation of biomarker-driven therapeutic approaches. [npj breast cancer] |
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| Scientists discuss molecular maintenance in leukemia stem cells in chronic myeloid leukemia and provide a more in-depth discussion of the dual-specificity kinase DYRK2, which has been identified as a novel actionable checkpoint in a critical leukemic network. [Experimental and Molecular Medicine] |
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| Merck announced that the FDA has approved an expanded label for KEYTRUDA®, Merck’s anti-PD-1 therapy, as monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma. [Merck & Co., Inc.] |
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| Agios Pharmaceuticals, Inc. announced the withdrawal of its European Marketing Authorization Application for TIBSOVO® for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-1 mutation. [Agios Pharmaceuticals, Inc] |
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| January 11 – January 12, 2021 Virtual |
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| Karolinska Institutet – Flemingsberg, Sweden |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| The University of Chicago – Chicago, Illinois, United States |
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| The University of Georgia – Athens, Georgia, United States |
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| Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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