Cancer Stem Cell News Volume 9.40 | Oct 21 2020

2020-10-21 | Volume 9.40

Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.40 – 21 October, 2020

WNT11-FZD7-DAAM1 Signaling Supports Tumor Initiating Abilities and Melanoma Amoeboid Invasion

Investigators showed that WNT11-FZD7-DAAM1 activated Rho-ROCK1/2-Myosin II and played a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation.
[Nature Communications]

Full ArticlePress Release

Survey Report: Where Is Pluripotent Stem Cell Research Now?
PUBLICATIONSRanked by the impact factor of the journal

Oxidative Phosphorylation to Promote the Stem and Immunoevasive Properties of Pancreatic Cancer Stem Cells

Researchers describe a 2D in vitro system for long-term enrichment of pancreatic CSCs that was amenable to biological and CSC-specific studies.
[Nature Communications]

Full Article

Miriplatin Ultrasmall Dots Suppress Triple Negative Breast Cancer Lung Metastasis by Targeting Circulating Tumor Cells

The authors found that ultrasmall Pt(II) dot active targeting nanoparticles displayed a superior DNA damage capability via enhanced-interactions with DNA and a significantly stronger effect in reducing CSC-like property of triple negative breast cancer cells, compared to conventional cisplatin and miriplatin.
[Journal of Controlled Release]

Full ArticleGraphical Abstract

Tenascin C Promotes Cancer Cell Plasticity in Mesenchymal Glioblastoma

Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.


Repression by Pluripotency Factors and Consequent Chemoresistance in Breast Cancer Stem-Like Cells Is Reversed by Aspirin

Investigators found in breast tumors that the expression of SMAR1 was decreased in CSCs through the cooperative interaction of the pluripotency factors Oct4 and Sox2 with the histone deacetylase HDAC1.
[Science SIgnaling]

Full Article

Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein

TRIM28 high level related to higher melanoma stemness as measured with several distinct scores and TRIM28HIGH-expressing melanoma cell lines possess the greater potential of melanosphere formation.

Full Article

TGFBI Modulates Tumor Hypoxia and Promotes Breast Cancer Metastasis

Researchers crossed the MMTV‐PyMT model of mammary gland tumourigenesis with a TgfbiΔ/Δ mouse, and studied the CSC content of the tumors. We performed RNAseq on wt and ko tumours, and analysed the tumour vasculature and the immune compartment by IHC and FACS.
[Molecular Oncology]


Ascorbate Inhibits Pancreatic Cancer Metastases via a Peroxide-Mediated Mechanism

Several in vitro and in vivo mechanisms involved in pancreatic cancer (PDAC) metastases were investigated following treatment with P-AscH. Serum from PDAC patients in clinical trials with P-AscH were tested for the presence and quantity of circulating tumor cell-derived nucleases.
[Scientific Reports]

Full Article

Mediates Tropism of Human Bone Marrow-Derived Mesenchymal Stem Cells toward CD133+/CD44+ Colon Cancer Stem Cells

Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133−/CD44−, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]


Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.

Classification of Triple-Negative Breast Cancer: Intratumoral Heterogeneity, Mechanisms of Drug Resistance, and Novel Therapies

Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across triple negative breast cancer subtypes, prompting the implementation of biomarker-driven therapeutic approaches.
[npj breast cancer]

Full Article

DYRK2 Controls a Key Regulatory Network in Chronic Myeloid Leukemia Stem Cells

Scientists discuss molecular maintenance in leukemia stem cells in chronic myeloid leukemia and provide a more in-depth discussion of the dual-specificity kinase DYRK2, which has been identified as a novel actionable checkpoint in a critical leukemic network.
[Experimental and Molecular Medicine]

Full Article

FDA Approves Expanded Indication for Merck’s KEYTRUDA® (pembrolizumab) in Adult Patients With Relapsed or Refractory Classical Hodgkin Lymphoma (cHL)

Merck announced that the FDA has approved an expanded label for KEYTRUDA®, Merck’s anti-PD-1 therapy, as monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma.
[Merck & Co., Inc.]

Press Release

Announces Withdrawal of European Marketing Authorization Application for TIBSOVO® as a Treatment for Relapsed or Refractory IDH1-mutant Acute Myeloid Leukemia

Agios Pharmaceuticals, Inc. announced the withdrawal of its European Marketing Authorization Application for TIBSOVO® for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-1 mutation.
[Agios Pharmaceuticals, Inc]

Press Release

Evolving Tumor Microenvironment In Cancer Progression: Mechanisms And Emerging Therapeutic Opportunities

January 11 – January 12, 2021

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Senior Researcher – Translational Medicine and Therapeutics for Leukemia

Karolinska Institutet – Flemingsberg, Sweden

Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

The University of British Columbia – Vancouver, British Columbia, Canada

Scientists – Stem Cell Factors in Epithelial Cancers

The University of Chicago – Chicago, Illinois, United States

Professor – Center for Molecular Medicine

The University of Georgia – Athens, Georgia, United States

Postdoctoral Position – Human Pluripotent Stem Cells, Hematopoiesis and Leukemia

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

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